Lortalamine

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Lortalamine
Clinical data
Routes of
administration		Oral
ATC code
  • None
Pharmacokinetic data
Elimination half-life5 hours
ExcretionRenal (98%)
Identifiers
  • 8-chloro-1,2,3,4,10,10a-hexahydro-2-methyl-4a,10-(iminoethano)-4aH-[1]-benzopyrano[3,2-c]-pyridin-12-one
JSmol)
  • Clc1ccc2O[C@]34NC(=O)C[C@@H](c2c1)[C@H]4CN(C)CC3

Lortalamine (LM-1404) is an antidepressant which was synthesized in the early 1980s.[1][2] It acts as a potent and highly selective norepinephrine reuptake inhibitor.[3][4] Lortalamine was under development for clinical use but was shelved, likely due to the finding that it produced ocular toxicity in animals.[5][6] It has been used to label the norepinephrine transporter in positron emission tomography studies.[4][7][8]

See also

References

  1. ISBN 0-412-46630-9
    .
  2. PMID 6113932
    .
  3. PMID 4091869
    .
  4. ^
    PMID 15914010
    .
  5. S2CID 2196891
    .
  6. PMID 2279460
    .
  7. S2CID 25110597
    .
  8. PMID 17073682
    .
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