Lubert Stryer
Lubert Stryer | |
---|---|
European Inventor of the Year (2006), Eli Lilly Award in Biological Chemistry | |
Scientific career | |
Fields | Biochemistry, fluorescence spectroscopy |
Institutions | Department of physics at Harvard; MRC Laboratory of Molecular Biology at Cambridge, UK; department of biochemistry at Stanford University; Yale University |
Notable students | Richard P. Haugland, Jeremy M. Berg |
Lubert Stryer (2 March 1938 - April 2024
Stryer received his B.S. degree from the
Research profile
Stryer and coworkers pioneered the use of fluorescence spectroscopy, particularly Förster resonance energy transfer (FRET), to monitor the structure and dynamics of biological macromolecules.[9][10] In 1967, Stryer and Haugland showed that the efficiency of energy transfer depends on the inverse sixth power of the distance between the donor and acceptor,[11][12] as predicted by Förster's theory. They proposed that energy transfer can serve as a spectroscopic ruler to reveal proximity relationships in biological macromolecules.
A second contribution was Stryer's discovery of the primary stage of amplification in visual excitation.[13][14] Stryer, together with Fung and Hurley, showed that a single photoexcited rhodopsin molecule activates many molecules of transducin, which in turn activate many molecules of a cyclic GMP phosphodiesterase. Stryer's laboratory has also contributed to our understanding of the role of calcium in visual recovery and adaptation.[15][16][17]
Stryer participated in developing light-directed, spatially addressable parallel chemical synthesis for the synthesis of peptides and polynucleotides.[18][19][20] Light-directed combinatorial synthesis has been used by Stephen Fodor and coworkers at Affymetrix to make DNA arrays containing millions of different sequences for genetic analyses.
Since 1975, Stryer has authored ten editions of the textbook Biochemistry.[21]
Stryer also chaired a National Research Council committee that produced a report entitled Bio2010: Transforming Undergraduate Education for Future Research Biologists.[22][23]
Honors
- American Chemical Society Award in Biological Chemistry (Eli Lilly Award in Biological Chemistry, 1970)[24]
- American Academy of Arts and Sciences (elected 1975)[25]
- National Academy of Sciences (elected 1984)[26]
- American Association for the Advancement of Science Newcomb Cleveland Prize (1992)[27]
- Honorary Doctor of Science degree, University of Chicago, 1992[28]
- Molecular Bioanalytics Award, German Society for Biochemistry and Molecular Biology, 2002[29]
- American Philosophical Society (2006)[3]
- National Medal of Science (2006)[30]
- European Inventor of the Year 2006 in the category "Small and medium-sized enterprises"[31]
Notable students
- Richard P. Haugland (Ph.D. 1970), founder of Molecular Probes, Inc.
- Richard A. Mathies (postdoc), dean of the college of chemistry, University of California, Berkeley,[32]
- Tobias Meyer (postdoc), now professor, department of chemical and systems biology, Stanford University[33][34]
- Cheng-Wen Wu (postdoc), former founding president of the Taiwan National Health Research Institutes, 1996-2005, now professor at the Taiwan Medical College.
- Biochemistrytextbook
References
- ^ https://www.genomeweb.com/people-news/lubert-stryer/622341
- ^ "Lubert Stryer".
- ^ a b c "Our Apologies | American Philosophical Society". Archived from the original on 2012-07-20. Retrieved 2012-03-10.
- ^ "President to Award 2005-2006 National Medals of Science and National Medals of Technology Honoring Nation's Leading Researchers, Inventors and Innovators - NSF - National Science Foundation".
- ISBN 978-1319498504.
- ^ "Archived copy". Archived from the original on 2012-11-14. Retrieved 2012-04-01.
{{cite web}}
: CS1 maint: archived copy as title (link) - ^ "Alumni - MRC Laboratory of Molecular Biology". MRC Laboratory of Molecular Biology.
- ^ McCarthy, Pumtiwitt. "Everything is illuminated: 'Reflections' on light and life by Lubert Stryer". American Society for Biochemistry and Molecular Biology. Retrieved 19 June 2016.
- PMID 5706935.
- ^ "Invitrogen - Molecular Probes - Press Release". Archived from the original on 2011-06-14. Retrieved 2010-10-18.
- PMID 5233469.
- ^ Lakowicz, J.R., 2006. Principles of Fluorescence Spectroscopy (Springer, 3rd ed., p. 449)
- PMID 6264430.
- ^ "Chemical & Engineering News - Serving the chemical, life sciences and laboratory worlds".
- S2CID 4253998.
- ^ <Ames, J.B., Ishima, R., Tanaka, T., Gordon, J.I., Stryer, L., Ikura, M., 1997. Molecular mechanics of calcium-myristoyl switches. Nature 389:198-202
- PMID 11115393.
- PMID 1990438.
- ^ Fodor, S.P.A., Pirrung, M.C., Read, J.L., and Stryer, L., Array of oligonucleotides on a solid substrate. U.S. Patent No. 5,445,934. Issued August 29, 1995
- ^ "2007 Newcomb Cleveland Prize Recipients". AAAS - The World's Largest General Scientific Society.
- ^ Latchman,D.S. (1995) Trends Biochem. Sci. 20:488.
- )
- PMID 14673487.
- ^ "Recipients - ACS Division of Biological Chemistry Website".
- ^ "American Academy of Arts & Sciences".
- ^ "National Academy of Sciences".
- ^ "AAAS Awards and Honors". archives.aaas.org. Retrieved 2019-10-23.
- ^ 1992 http://convocation.uchicago.edu/page/1990 Archived 2019-02-16 at the Wayback Machine
- ^ "Roche Life Science | Welcome". lifescience.roche.com. Retrieved 2019-10-24.
- ^ "Lubert Stryer".
- ^ European Patent Office. "EPO - Stephen P.A. Fodor, Michael C. Pirrung, J. Leighton Read and Lubert Stryer (Affymax Research Institute, Palo Alto, USA)".
- ^ "Faculty & Research".
- ^ "Meyer Lab". Archived from the original on 2009-04-11. Retrieved 2012-04-01.
- ^ "Tobias Meyer - Mrs. George A. Winzer Professor in Cell Biology and Professor of Chemical & Systems Biology | Welcome to Bio-X".