Luca Turin

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Luca Turin
Born (1953-11-20) 20 November 1953 (age 70)
Beirut, Lebanon
Occupationbiophysicist
Known forVibration theory of olfaction

Luca Turin (born 20 November 1953) is a

fragrance
industry.

Early life and education

Turin was born in

UN diplomat and chief architect of the Palestinian refugee camps,[1] and his mother, Adela Turin (born Mandelli), is an art historian, designer, and award-winning children's author.[2] Turin studied Physiology and Biophysics at University College London and earned his PhD in 1978.[3] He worked at the CNRS from 1982-1992, and served as lecturer in Biophysics
at University College London from 1992-2000.

Career

After leaving the CNRS, Turin first held a visiting research position at the National Institutes of Health in North Carolina[4] before moving back to London, where he became a lecturer in biophysics at University College London. In 2001 Turin was hired as CTO of start-up company Flexitral, based in Chantilly, Virginia, to pursue rational odorant design based on his theories. In April 2010 he described this role in the past tense,[5] and the company's domain name appears to have been surrendered.[6]

In 2010, Turin was based at

MIT, working on a project to develop an electronic nose using natural receptors, financed by DARPA.[5] In 2014 he moved to the Institute of Theoretical Physics at the University of Ulm where he was a Visiting Professor.[7] He is a Stavros Niarchos Researcher [8] in the neurobiology division at the Biomedical Sciences Research Center Alexander Fleming in Greece.[9]
In 2021 he moved to the University of Buckingham, UK as Professor of Physiology in the Medical School.

Vibration theory of olfaction

A major prediction of Turin's vibration theory of olfaction is the isotope effect: that the normal and deuterated versions of a compound should smell different due to unique vibration frequencies, despite having the same shape. A 2001 study by Haffenden et al. showed humans able to distinguish benzaldehyde from its deuterated version.[10]

However, experimental tests published in Nature Neuroscience in 2004 by Keller and Vosshall failed to support this prediction, with human subjects unable to distinguish acetophenone and its deuterated counterpart.[11] The study was accompanied by an editorial, which considered the work of Keller and Vosshall to be "refutation of a theory that, while provocative, has almost no credence in scientific circles." It continued, "The only reason for the authors to do the study, or for Nature Neuroscience to publish it, is the extraordinary -- and inappropriate -- degree of publicity that the theory has received from uncritical journalists."[12] The journal also published a review of The Emperor of Scent, calling Chandler Burr's book about Turin and his theory "giddy and overwrought."[13] However, tests with animals have shown fish and insects able to distinguish isotopes by smell.[14][15] Biophysical simulations published in Physical Review Letters in 2007 suggest that Turin's proposal is viable from a physics standpoint.[16]

The vibration theory received possible support from a 2004 paper published in the journal Organic Biomolecular Chemistry by Takane and Mitchell, which shows that odor descriptions in the olfaction literature correlate more strongly with vibrational frequency than with molecular shape.[17]

In 2011, Turin and colleagues published a paper in

PNAS showing drosophila fruit flies can distinguish between odorants and their deuterated counterparts. Tests on drosophila differ from human experiments by using an animal subject known to have a good sense of smell and free from psychological biases that may complicate human tests.[18] Drosophila were trained to avoid the deuterated odorant in a deuterated/normal pair, indicating a difference in odor. Furthermore, drosophila trained to avoid one deuterated odorant also avoided other deuterated odorants, chemically unrelated, indicating that the deuterated bond itself had a distinct smell. The authors identified a vibrational frequency that could be responsible and found it close to one found in nitriles. When flies trained to avoid deuterated odorants were exposed to the nitrile and its non-nitrile counterpart, the flies also avoided the nitrile, consistent with the theory that fly olfaction detects molecular vibrations.[19]

Two years later, in 2013, Turin and colleagues published a study in

inelastic electron tunnelling spectroscopy, which exploits a quantum effect, his theory of olfaction mechanism has been described as an example of quantum biology.[21]

In response to Turin's 2013 paper, involving deuterated and undeuterated

PNAS, Turin et al.[25] raise concerns about Block et al.[22] and Block et al. respond.[26] A recent study[27]
describes the responses of primary olfactory neurons in tissue culture to isotopes and finds that a small fraction of the population (<1%) clearly discriminates between isotopes, some even giving an all-or-or -none response to H or D isotopomers of octanal. The authors attribute this to "hypersensitivity" of some receptors to differences in hydrophobicity between normal and deuterated odorants.

Biological electronics

Turin filed one of the first patents for a semiconductor device made with protein.[28] Turin's recent work focuses on the relevance of his olfaction theory to more general mechanisms of G-protein coupled receptor activation. In an article[29] in Inference Review, he proposed that the electronic mechanism was a special case of a more general involvement of electron currents in GPCRs. A 2019 preprint[30] argues that the highest-resolution x-ray diffraction structure of rhodopsin,[31] considered the ancestor of all GPCRs, contains the elements of an electronic circuit. He has also reported detection of non-equilibrium electron spins in Drosophila by their radiofrequency emissions,[32] though this is described as a "work in progress".

Role in the case of Henri Korn

In 1988, Turin began work at the lab led by neuroscience researcher Henri Korn at the Pasteur Institute. There, Turin and his colleague Nicole Ropert reported to their superiors that they believed some of Korn's research on neurotransmitters was based on fabricated results.[33] After Turin made a formal request that the CNRS investigate the allegations, he was told to find work outside France; Ropert was also asked to leave.[34]

Korn was awarded the prestigious Richard Lounsbery Award in 1992 and became a member of the National Academy of Sciences in the U.S. and the French Academy of Sciences.[35] Then in 2007, re-analysis of Korn's data by Jacques Ninio in the Journal of Neurophysiology showed serious anomalies that suggested the results were indeed fabricated.[33]

Publications

Main article: Perfumes: The Guide

Turin is the author of the book The Secret of Scent (2006), which details the history and science of his theory of olfaction; an acclaimed critical guide to perfume in French, Parfums: Le Guide, with two editions in 1992 and 1994; and is co-author of the English-language books Perfumes: The A-Z Guide (2008) and The Little Book of Perfumes (2011). He is also the subject of the 2002 book The Emperor of Scent by Chandler Burr[4] and the 1995 BBC Horizons documentary "A Code in the Nose."

Since 2003, Turin has also written a regular column on perfume, "Duftnote," for NZZ Folio, the German-language monthly magazine of Swiss newspaper Neue Zürcher Zeitung. The column is also published in English on the magazine's website.[36] The column ended in 2014. The collected columns are published as a book[37]

Awards and honors

In 2001 and 2004, Turin won the Prix Jasmin, the highest honor for perfume writing in France. He won the Jasmine Prize in the UK in 2009.[38]

Bibliography

References

  1. doi:10.1016/0197-3975(78)90029-2
    .
  2. ^ "Adela Turin".
  3. ^ artandolfactionawards.com Luca Turin Archived 2016-02-07 at the Wayback Machine
  4. ^
    ISBN 978-0-375-50797-7
    .
  5. ^ a b Nina Sinatra, The science of smell, The Tech, MIT, 23 April 2010
  6. ^ "Welcome to flexitral.com". GoDaddy. Retrieved 18 October 2018. This Web page is parked for FREE, courtesy of GoDaddy.com.
  7. ^ Institute of Theoretical Physics Luca Turin
  8. ^ "Stavros Niarchos Researchers".
  9. ^ "Neuroscience". Archived from the original on 7 December 2015. Retrieved 5 August 2018.
  10. doi:10.1016/S0308-8146(00)00287-9
    .
  11. S2CID 1073550
    .
  12. PMID 15048113
    .
  13. doi:10.1038/nn0403-335
    .
  14. ISBN 9780444820136
    .
  15. S2CID 5203445
    .
  16. S2CID 1519986
    .
  17. PMID 15534702
    .
  18. doi:10.1038/news.2011.39
    .
  19. PMID 21321219
    .
  20. ^
    PMID 23372854
    .
  21. ^ Palmer, Jason. "Quantum biology: Do weird physics effects abound in nature?". BBC. Retrieved 23 May 2013.
  22. ^
    PMID 25901328
    .
  23. PMID 26015552
    .
  24. ^ Everts S (2015). "Receptor Research Reignites A Smelly Debate". Chemical & Engineering News. 93 (18): 29–30.
  25. PMID 26045494
    .
  26. PMID 26045493
    .
  27. PMID 30343564
    .
  28. ^ [1], "Semiconductor structure using protein as its active element", issued 1991-12-04 
  29. doi:10.37282/991819.16.12
    . Retrieved 17 August 2019.
  30. doi:10.1101/650531
    .
  31. PMID 15327956
    .
  32. arXiv:1907.04764v1 [physics.bio-ph
    ].
  33. ^
    PMID 17851481
    .
  34. ^ de Pracontal, Michel (27 September 2007). "Fraude à l'Institut Pasteur ? Savants au bord de la crise de nerfs". Le Nouvel Observateur (in French). No. 2238. p. 110. Je leur ai expliqué la situation. J'ai dit que le devoir d'un scientifique était d'établir la vérité et que je m'étais trouvé dans un laboratoire dont le directeur agissait comme un faussaire. On m'a répondu que j'avais cinq jours pour me trouver un autre poste, de préférence hors de France !
  35. ^ de Pracontal, Michel (27 September 2007). "Fraude à l'Institut Pasteur ? Savants au bord de la crise de nerfs". Le Nouvel Observateur (in French). No. 2238. p. 108.
  36. ^ nzzfolio.ch NZZ-Folio, Duftnote[full citation needed]
  37. ^ Turin, Luca; Sanchez, Tania. Folio Columns 2003-2014.
  38. ^ perfumestheguide.com Luca Turin Archived 2016-01-26 at the Wayback Machine

External links

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