Lyme disease

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Lyme encephalopathy
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Not to be confused with phytophotodermatitis, also known as "lime disease".

Lyme disease
Other namesLyme borreliosis
tiredness[1]
ComplicationsFacial nerve paralysis, arthritis, meningitis,[1] Heart rhythm irregularities[2]
Usual onsetA week after a bite[1]
CausesBorrelia spread by ticks[3]
Diagnostic methodBased on symptoms, tick exposure, blood tests[4]
PreventionPrevention of tick bites (clothing the limbs, DEET), doxycycline[3]
MedicationDoxycycline, amoxicillin, ceftriaxone, cefuroxime[3]
Frequency~476k/year in U.S. (a likely overestimate), 200k/year in Europe[5][6][7]

Lyme disease, also known as Lyme borreliosis, is a

heart palpitations.[1] Months to years later, repeated episodes of joint pain and swelling may occur.[1] Occasionally, shooting pains or tingling in the arms and legs may develop.[1] Despite appropriate treatment, about 10 to 20% of those affected develop joint pains, memory problems, and tiredness for at least six months.[1][11]

Lyme disease is transmitted to humans by the bites of infected ticks of the genus Ixodes.

antibodies in the blood.[4][17] Blood tests are often falsely negative in the early stages of the disease.[3] Testing of individual ticks is not typically useful.[18]

Prevention includes efforts to prevent tick bites by wearing clothing to cover the arms and legs and using

tweezers.[19] If the removed tick is full of blood a single dose of doxycycline may be used to prevent the development of infection but is not generally recommended since the development of infection is rare.[3] If an infection develops, a number of antibiotics are effective, including doxycycline, amoxicillin and cefuroxime.[3] Standard treatment usually lasts for two or three weeks.[3] Some people develop a fever and muscle and joint pains from treatment, which may last for one or two days.[3] In those who develop persistent symptoms, long-term antibiotic therapy has not been found to be useful.[3][20]

Lyme disease is the most common disease spread by ticks in the Northern Hemisphere.[21][7] Infections are most common in the spring and early summer.[3] Lyme disease was diagnosed as a separate condition for the first time in 1975 in Lyme, Connecticut. It was originally mistaken for juvenile rheumatoid arthritis.[22] The bacterium involved was first described in 1981 by Willy Burgdorfer.[23] Chronic symptoms following treatment are known as "post-treatment Lyme disease syndrome" (PTLDS).[20] PTLDS is different from chronic Lyme disease, a term no longer supported by scientists and used in different ways by different groups.[20][24] Some healthcare providers claim that PTLDS is caused by persistent infection, but this is not believed to be true because no evidence of persistent infection can be found after standard treatment.[25]

As of 2023 clinical trials of proposed human vaccines for Lyme disease were being carried out, but no vaccine was available. A vaccine, LYMERix, was produced, but discontinued in 2002 due to insufficient demand.[26] There are several vaccines for the prevention of Lyme disease in dogs.

Signs and symptoms

Lyme disease can produce a broad range of symptoms.

  • 20% of Lyme rashes in the United States show a "bull's eye" or "target-like" appearance.[27][28][29]
    20% of Lyme rashes in the United States show a "bull's eye" or "target-like" appearance.[27][28][29]
  • Erythema migrans ("redness migrating") on a woman's neck.[30] Rashes from non-Lyme causes may look similar.[31][32]
    Erythema migrans ("redness migrating") on a woman's neck.[30] Rashes from non-Lyme causes may look similar.[31][32]

The incubation period is usually one to two weeks, but can be much shorter (days) or much longer (months to years).[33] Lyme symptoms most often occur from the month of May to September in the Northern Hemisphere because the nymphal stage of the tick is responsible for most cases.[33]

Early localized infection

80% of Lyme infections begin with a rash of some sort at the site of a tick bite, often near skin folds such as the

armpit, groin, back of the knee, or the trunk under clothing straps, or in children's hair, ears, or neck.[27][3] Most people who get infected do not remember seeing a tick or a bite. The rash appears typically one or two weeks (range 3–32 days) after the bite and expands 2–3 cm per day up to a diameter of 5–70 cm (median is 16 cm).[27][3][31]

The rash is usually circular or oval, red or bluish, and may have an elevated or darker center.[3][28][29] This rash is termed an Erythema Migrans (EM) which translates as "Redness Migrating." In about 79% of cases in Europe, this rash gradually clears from the center toward the edges possibly forming a "bull's eye" or "target-like" pattern, but this clearing only happens in 19% of cases in endemic areas of the United States.[31][28][29] The rash may feel warm, usually is not itchy, is rarely tender or painful, and takes up to four weeks to resolve if untreated.[3]

The Lyme rash is often accompanied by symptoms of a flu-like illness, including fatigue, headache, body aches, fever, and chills [though usually neither nausea nor upper-respiratory problems]. These symptoms may also appear without a rash or linger after the rash has disappeared. Lyme can progress to later stages without a rash or these symptoms.[3]

People with high fever for more than two days or whose other symptoms of viral-like illness do not improve despite

tick-borne diseases such as ehrlichiosis and babesiosis.[34]

Of course, not everyone with Lyme disease has all the symptoms, and many of these symptoms can occur with other diseases as well.[35]

Asymptomatic infection exists, but occurs in less than 7% of infected individuals in the United States.[36] Asymptomatic infection may be much more common among those infected in Europe.[37]

Early disseminated infection

Within days to weeks after the onset of local infection, the Borrelia bacteria may spread through the lymphatic system or bloodstream. In 10–20% of untreated cases, EM rashes develop at sites across the body that bear no relation to the original tick bite.[27] Transient muscle pains and joint pains are also common.[27]

In about 10–15% of untreated people, Lyme causes neurological problems known as

pain and less often weakness, numbness, or altered sensation in the areas of the body served by nerves connected to the affected roots, e.g. limb(s) or part(s) of trunk. The pain is often described as unlike any other previously felt, excruciating, migrating, worse at night, rarely symmetrical, and often accompanied by extreme sleep disturbance.[39][42] Mononeuritis multiplex is an inflammation causing similar symptoms in one or more unrelated peripheral nerves.[38][34] Rarely, early neuroborreliosis may involve inflammation of the brain or spinal cord, with symptoms such as confusion, abnormal gait, ocular movements, or speech, impaired movement, impaired motor planning, or shaking.[34][39]

In North America, facial palsy is the typical early neuroborreliosis presentation, occurring in 5–10% of untreated people, in about 75% of cases accompanied by lymphocytic meningitis.

impairment of motor or sensory function of the lower limbs may occur.[37] In European children, the most common manifestations are facial palsy (in 55%), other cranial neuritis, and lymphocytic meningitis (in 27%).[39]

In about 4–10% of untreated cases in the U.S. and 0.3–4% of untreated cases in Europe, typically between June and December, about one month (range 4 days – 7 months) after the tick bite, the infection may cause heart complications known as Lyme

radicular pain.[45] In some people, however, carditis may be the first manifestation of Lyme disease.[45] Lyme carditis in 19–87% of people adversely impacts the heart's electrical conduction system, causing atrioventricular block that often manifests as heart rhythms that alternate within minutes between abnormally slow and abnormally fast.[45][46] In 10–15% of people, Lyme causes myocardial complications such as cardiomegaly, left ventricular dysfunction, or congestive heart failure.[45]

Another skin condition, found in Europe but not in North America, is

borrelial lymphocytoma, a purplish lump that develops on the ear lobe, nipple, or scrotum.[47]

Late disseminated infection

Lyme arthritis caused this 3-year-old girl's knee to become swollen. Though painless, it did make her limp.[48]

Lyme arthritis occurs in up to 60% of untreated people, typically starting about six months after infection.[27] It usually affects only one or a few joints, often a knee or possibly the hip, other large joints, or the temporomandibular joint.[34][49] Usually, large joint effusion and swelling occur, but only mild or moderate pain.[34] Without treatment, swelling and pain typically resolve over time, but periodically return.[34] Baker's cysts may form and rupture.

In early US studies of Lyme disease, a rare peripheral neuropathy was described that included numbness, tingling, or burning starting at the feet or hands and over time possibly moving up the limbs. In a later analysis that discovered poor documentation of this manifestation, experts wondered if it exists at all in the US or is merely very rare.[34][50]

A neurologic syndrome called Lyme encephalopathy is associated with subtle memory and cognitive difficulties,

autism).[54]

Acrodermatitis chronica atrophicans is a chronic skin disorder observed primarily in Europe among the elderly.[47] It begins as a reddish-blue patch of discolored skin, often on the backs of the hands or feet. The lesion slowly atrophies over several weeks or months, with the skin becoming first thin and wrinkled and then, if untreated, completely dry and hairless.[55] It is also associated with peripheral neuropathy.[50]

Cause

Main article: Lyme disease microbiology
Borrelia bacteria, the causative agents of Lyme disease, magnified

Lyme disease is caused by

sensu lato, and show a great deal of genetic diversity.[57]

B. burgdorferi sensu lato is a species complex made up of 20 accepted and three proposed genospecies. Eight species are known to cause Lyme disease: B. mayonii (found in North America), B. burgdorferi

sensu stricto (found in North America and Europe), B. afzelii, B. garinii, B. spielmanii, and B. lusitaniae (all found in Eurasia).[58][59][16][9]
Some studies have also proposed that B. valaisiana may sometimes infect humans, but this species does not seem to be an important cause of disease.[60][61]

Further information: Weather and climate effects on Lyme disease exposure

Tick life cycle

Deer tick life cycle
Ixodes scapularis, the primary vector of Lyme disease in eastern North America

Three stages occur in the life cycle of a tick - larva, nymph, and adult. During the nymph stage, ticks most frequently transmit Lyme disease and are usually most active in late spring and early summer in regions where the climate is mild. During the adult stage, Lyme disease transmission is less common because adult ticks are less likely to bite humans and tend to be larger in size, so can be easily seen and removed.[62]

Transmission

Lyme disease is classified as a

vectors of Lyme disease (also the vector for Babesia).[64] Most infections are caused by ticks in the nymphal stage, because they are very small, thus may feed for long periods of time undetected.[63] Nymphal ticks are generally the size of a poppy seed and sometimes with a dark head and a translucent body.[65] Or, the nymphal ticks can be darker.[66] The younger larval ticks are very rarely infected.[67] Although deer are the preferred hosts of adult deer ticks, and tick populations are much lower in the absence of deer, ticks generally do not acquire Borrelia from deer, instead they obtain them from infected small mammals such as the white-footed mouse, and occasionally birds.[68] Areas where Lyme is common are expanding.[69]

Within the tick midgut, the Borrelia's outer surface protein A (OspA) binds to the tick receptor for OspA, known as TROSPA. When the tick feeds, the Borrelia downregulates OspA and upregulates OspC, another surface protein. After the bacteria migrate from the midgut to the salivary glands, OspC binds to Salp15, a tick salivary protein that appears to have immunosuppressive effects that enhance infection.[70] Successful infection of the mammalian host depends on bacterial expression of OspC.[71]

Tick bites often go unnoticed because of the small size of the tick in its nymphal stage, as well as tick secretions that prevent the host from feeling any itch or pain from the bite. However, transmission is quite rare, with only about 1.2 to 1.4 percent of recognized tick bites resulting in Lyme disease.[72]

While

bacteriolytic activities of the alternative complement pathway of various host species may determine its reservoir host association.[73]

Budding research has suggested that B. burgdorferi sensu lato may also be able to form enzootic cycle among lizard populations;[74] this was previously assumed not to be possible in major areas containing populations of lizards, such as California. Except for one study in Europe,[73] much of the data implicating lizards is based on DNA detection of the spirochete and has not demonstrated that lizards are able to infect ticks feeding upon them.[74][75][76][77] As some experiments suggest lizards are refractory to infection with Borrelia, it appears likely their involvement in the enzootic cycle is more complex and species-specific.[78]

Tick Ixodes ricinus, developmental stages

In Europe, the main vector is

castor bean tick.[79] In China, Ixodes persulcatus (the taiga tick) is probably the most important vector.[80] In North America, the black-legged tick or deer tick (Ixodes scapularis) is the main vector on the East Coast.[67]

The lone star tick (

spirochetes,[81] though it may be implicated in a related syndrome called southern tick-associated rash illness, which resembles a mild form of Lyme disease.[82]

On the

Western Fence Lizard that are resistant to Borrelia infection appears to diminish transmission of Lyme disease in the West.[84][78]

Transmission can occur across the placenta during pregnancy and as with a number of other spirochetal diseases, adverse pregnancy outcomes are possible with untreated infection; prompt treatment with antibiotics reduces or eliminates this risk.[85][86][87][88]

There is no scientific evidence to support Lyme disease transmission via blood transfusion, sexual contact, or breast milk.[89]

Tick-borne co-infections

Main article: Tick-borne disease

Ticks that transmit B. burgdorferi to humans can also carry and transmit several other microbes, such as Babesia microti and Anaplasma phagocytophilum, which cause the diseases babesiosis and human granulocytic anaplasmosis (HGA), respectively.[90] Among people with early Lyme disease, depending on their location, 2–12% will also have HGA and 2–10% will have babesiosis.[54] Ticks in certain regions also transmit viruses that cause tick-borne encephalitis and Powassan virus disease.[91][54] Co-infections of Lyme disease may not require additional treatment, since they may resolve on their own or—as in the case of HGA—can be treated with the doxycycline prescribed for Lyme.[34] Persistent fever or compatible anomalous laboratory findings may be indicative of a co-infection.[54]

Pathophysiology

B. burgdorferi can spread throughout the body during the course of the disease, and has been found in the skin, heart, joints, peripheral nervous system, and central nervous system.[71][92] B. Burgdorferi does not produce toxins.[93] Therefore, many of the signs and symptoms of Lyme disease are a consequence of the immune response to spirochete in those tissues.[94]

B. burgdorferi is injected into the skin by the bite of an infected Ixodes tick.

Neutrophils, however, which are necessary to eliminate the spirochetes from the skin, fail to appear in necessary numbers in the developing EM lesion because tick saliva inhibits neutrophil function. This allows the bacteria to survive and eventually spread throughout the body.[97]

Days to weeks following the tick bite, the spirochetes spread via the bloodstream to joints, heart, nervous system, and distant skin sites, where their presence gives rise to the variety of symptoms of the disseminated disease. The spread of B. burgdorferi is aided by the attachment of the host protease plasmin to the surface of the spirochete.[98]

If untreated, the bacteria may persist in the body for months or even years, despite the production of B. burgdorferi antibodies by the immune system.[99] The spirochetes may avoid the immune response by decreasing expression of surface proteins that are targeted by antibodies, antigenic variation of the VlsE surface protein, inactivating key immune components such as complement, and hiding in the extracellular matrix, which may interfere with the function of immune factors.[100][101]

Immunological studies

Exposure to the Borrelia bacterium during Lyme disease possibly causes a long-lived and damaging

autoimmune disease.[103] The production of this reaction might be due to a form of molecular mimicry, where Borrelia avoids being killed by the immune system by resembling normal parts of the body's tissues.[104][105]

Chronic symptoms from an autoimmune reaction could explain why some symptoms persist even after the spirochetes have been eliminated from the body. This hypothesis may explain why chronic arthritis persists after antibiotic therapy, similar to rheumatic fever, but its wider application is controversial.[106][107]

Diagnosis

Lyme disease is

ticks, and possibly laboratory tests.[3][27] People with symptoms of early Lyme disease should have a total body skin examination for EM rashes and asked whether EM-type rashes had manifested within the last 1–2 months.[34] Presence of an EM rash and recent tick exposure (i.e., being outdoors in a likely tick habitat where Lyme is common, within 30 days of the appearance of the rash) are sufficient for Lyme diagnosis; no laboratory confirmation is needed or recommended.[3][27][108][109] Most people who get infected do not remember a tick or a bite, and the EM rash need not look like a bull's eye (most EM rashes in the U.S. do not) or be accompanied by any other symptoms.[3][110] In the U.S., Lyme is most common in the New England and Mid-Atlantic states and parts of Wisconsin and Minnesota, but it is expanding into other areas.[69] Several bordering areas of Canada also have high Lyme risk.[111]

In the absence of an EM rash or history of tick exposure, Lyme diagnosis depends on laboratory confirmation.

antibodies against those bacteria in the blood.[113] A positive antibody test result does not by itself prove active infection but can confirm an infection that is suspected because of symptoms, objective findings, and history of tick exposure in a person.[64] Because as many as 5–20% of the normal population have antibodies against Lyme, people without history and symptoms suggestive of Lyme disease should not be tested for Lyme antibodies: a positive result would likely be false, possibly causing unnecessary treatment.[34][39]

In some cases, when history, signs, and symptoms are strongly suggestive of early disseminated Lyme disease,

empiric treatment may be started and reevaluated as laboratory test results become available.[43][114]

Laboratory testing

Tests for antibodies in the blood by ELISA and Western blot is the most widely used method for Lyme diagnosis. A two-tiered protocol is recommended by the Centers for Disease Control and Prevention (CDC): the sensitive ELISA test is performed first, and if it is positive or equivocal, then the more specific Western blot is run.[115] The immune system takes some time to produce antibodies in quantity. After Lyme infection onset, antibodies of types IgM and IgG usually can first be detected respectively at 2–4 weeks and 4–6 weeks, and peak at 6–8 weeks.[116] When an EM rash first appears, detectable antibodies may not be present. Therefore, it is recommended that testing not be performed and diagnosis be based on the presence of the EM rash.[34] Up to 30 days after suspected Lyme infection onset, infection can be confirmed by detection of IgM or IgG antibodies; after that, it is recommended that only IgG antibodies be considered.[116] A positive IgM and negative IgG test result after the first month of infection is generally indicative of a false-positive result.[117] The number of IgM antibodies usually collapses 4–6 months after infection, while IgG antibodies can remain detectable for years.[116]

Other tests may be used in neuroborreliosis cases. In Europe, neuroborreliosis is usually caused by

nerve conduction studies can be used to monitor objectively the response to treatment.[40]

In Lyme carditis, electrocardiograms are used to evidence heart conduction abnormalities, while echocardiography may show myocardial dysfunction.[45] Biopsy and confirmation of Borrelia cells in myocardial tissue may be used in specific cases but are usually not done because of risk of the procedure.[45]

antibodies of Borrelia. PCR has the advantage of being much faster than culture. However, PCR tests are susceptible to false positive results, e.g. by detection of debris of dead Borrelia cells or specimen contamination.[120][39] Even when properly performed, PCR often shows false-negative results because few Borrelia cells can be found in blood and cerebrospinal fluid (CSF) during infection.[121][39] Hence, PCR tests are recommended only in special cases, e.g. diagnosis of Lyme arthritis, because it is a highly sensitive way of detecting ospA DNA in synovial fluid.[122] Although sensitivity of PCR in CSF is low, its use may be considered when intrathecal antibody production test results are suspected of being falsely negative, e.g. in very early (< 6 weeks) neuroborreliosis or in immunosuppressed people.[39]

Several other forms of laboratory testing for Lyme disease are available, some of which have not been adequately validated. OspA antigens, shed by live Borrelia bacteria into urine, are a promising technique being studied.[123] The use of nanotrap particles for their detection is being looked at and the OspA has been linked to active symptoms of Lyme.[124][125] High titers of either immunoglobulin G (IgG) or immunoglobulin M (IgM) antibodies to Borrelia antigens indicate disease, but lower titers can be misleading, because the IgM antibodies may remain after the initial infection, and IgG antibodies may remain for years.[126]

The CDC does not recommend urine antigen tests, PCR tests on urine, immunofluorescent staining for cell-wall-deficient forms of B. burgdorferi, and lymphocyte transformation tests.[121]

Imaging

Neuroimaging is controversial in whether it provides specific patterns unique to neuroborreliosis, but may aid in differential diagnosis and in understanding the pathophysiology of the disease.[127] Though controversial, some evidence shows certain neuroimaging tests can provide data that are helpful in the diagnosis of a person. Magnetic resonance imaging (MRI) and single-photon emission computed tomography (SPECT) are two of the tests that can identify abnormalities in the brain of a person affected with this disease. Neuroimaging findings in an MRI include lesions in the periventricular white matter, as well as enlarged ventricles and cortical atrophy. The findings are considered somewhat unexceptional because the lesions have been found to be reversible following antibiotic treatment. Images produced using SPECT show numerous areas where an insufficient amount of blood is being delivered to the cortex and subcortical white matter. However, SPECT images are known to be nonspecific because they show a heterogeneous pattern in the imaging. The abnormalities seen in the SPECT images are very similar to those seen in people with cerebral vasculitis and Creutzfeldt–Jakob disease, which makes them questionable.[128]

Differential diagnosis

Community clinics have been reported to misdiagnose 23–28% of

spider bites are more common in the limbs, tend to be more painful and itchy or become swollen, and some may cause necrosis (sinking dark blue patch of dead skin).[27][3] Cellulitis most commonly develops around a wound or ulcer, is rarely circular, and is more likely to become swollen and tender.[27][3] EM rashes often appear at sites that are unusual for cellulitis, such as the armpit, groin, abdomen, or back of knee.[27] Like Lyme, shingles often begins with headache, fever, and fatigue, which are followed by pain or numbness. However, unlike Lyme, in shingles these symptoms are usually followed by appearance of rashes composed of multiple small blisters along with a nerve's dermatome, and shingles can also be confirmed by quick laboratory tests.[129]

Facial palsy caused by Lyme disease (LDFP) is often misdiagnosed as Bell's palsy.[43] Although Bell's palsy is the most common type of one-sided facial palsy (about 70% of cases), LDFP can account for about 25% of cases of facial palsy in areas where Lyme disease is common.[43] Compared to LDFP, Bell's palsy much less frequently affects both sides of the face.[43] Even though LDFP and Bell's palsy have similar symptoms and evolve similarly if untreated, corticosteroid treatment is beneficial for Bell's Palsy, while being detrimental for LDFP.[43] Recent history of exposure to a likely tick habitat during warmer months, EM rash, viral-like symptoms such as headache and fever, and/or palsy in both sides of the face should be evaluated for the likelihood of LDFP; if it is more than minimal, empiric therapy with antibiotics should be initiated, without corticosteroids, and reevaluated upon completion of laboratory tests for Lyme disease.[43]

Unlike

facial palsy, or partial vision obstruction and having much lower percentage of polymorphonuclear leukocytes in CSF.[34]

Lyme radiculopathy affecting the limbs is often misdiagnosed as a radiculopathy caused by nerve root compression, such as sciatica.[112][130] Although most cases of radiculopathy are compressive and resolve with conservative treatment (e.g., rest) within 4–6 weeks, guidelines for managing radiculopathy recommend first evaluating risks of other possible causes that, although less frequent, require immediate diagnosis and treatment, including infections such as Lyme and shingles.[131] A history of outdoor activities in likely tick habitats in the last 3 months possibly followed by a rash or viral-like symptoms, and current headache, other symptoms of lymphocytic meningitis, or facial palsy would lead to suspicion of Lyme disease and recommendation of serological and lumbar puncture tests for confirmation.[131]

Lyme radiculopathy affecting the trunk can be misdiagnosed as myriad other conditions, such as diverticulitis and acute coronary syndrome.[44][112] Diagnosis of late-stage Lyme disease is often complicated by a multifaceted appearance and nonspecific symptoms, prompting one reviewer to call Lyme the new "great imitator".[132] As all people with later-stage infection will have a positive antibody test, simple blood tests can exclude Lyme disease as a possible cause of a person's symptoms.[133]

Prevention

Tick bites may be prevented by avoiding or reducing time in likely tick habitats and taking precautions while in and when getting out of one.[134][8]

Most Lyme human infections are caused by

leaf litter or wood piles.[27][135] Tick densities tend to be highest in woodlands, followed by unmaintained edges between woods and lawns (about half as high), ornamental plants and perennial groundcover (about a quarter), and lawns (about 30 times less).[136] Ixodes larvae and nymphs tend to be abundant also where mice nest, such as stone walls and wood logs.[136] Ixodes larvae and nymphs typically wait for potential hosts ("quest") on leaves or grasses close to the ground with forelegs outstretched; when a host brushes against its limbs, the tick rapidly clings and climbs on the host looking for a skin location to bite.[137] In Northeastern United States, 69% of tick bites are estimated to happen in residences, 11% in schools or camps, 9% in parks or recreational areas, 4% at work, 3% while hunting, and 4% in other areas.[136] Activities associated with tick bites around residences include yard work, brush clearing, gardening, playing in the yard, and letting dogs or cats that roam outside in woody or grassy areas into the house.[136][134] In parks, tick bites often happen while hiking or camping.[136] Walking on a mowed lawn or center of a trail without touching adjacent vegetation is less risky than crawling or sitting on a log or stone wall.[136][138] Pets should not be allowed to roam freely in likely tick habitats.[135]

As a precaution, CDC recommends soaking or spraying clothes, shoes, and camping gear such as tents, backpacks and sleeping bags with 0.5% permethrin solution and hanging them to dry before use.[134][139] Permethrin is odorless and safe for humans but highly toxic to ticks.[140] After crawling on permethrin-treated fabric for as few as 10–20 seconds, tick nymphs become irritated and fall off or die.[140][141] Permethrin-treated closed-toed shoes and socks reduce by 74 times the number of bites from nymphs that make first contact with a shoe of a person also wearing treated shorts (because nymphs usually quest near the ground, this is a typical contact scenario).[140] Better protection can be achieved by tucking permethrin-treated trousers (pants) into treated socks and a treated long-sleeve shirt into the trousers so as to minimize gaps through which a tick might reach the wearer's skin.[138] Light-colored clothing may make it easier to see ticks and remove them before they bite.[138] Military and outdoor workers' uniforms treated with permethrin have been found to reduce the number of bite cases by 80–95%.[141] Permethrin protection lasts several weeks of wear and washings in customer-treated items and up to 70 washings for factory-treated items.[139] Permethrin should not be used on human skin, underwear or cats.[139][142]

The

IR3535 (a derivative of amino acid beta-alanine), oil of lemon eucalyptus (OLE, a natural compound) and OLE's active ingredient para-menthane-diol (PMD).[134][143][144] Unlike permethrin, repellents repel but do not kill ticks, protect for only several hours after application, and may be washed off by sweat or water.[139] The most popular repellent is DEET in the U.S. and picaridin in Europe.[144] Unlike DEET, picaridin is odorless and is less likely to irritate the skin or harm fabric or plastics.[144] Repellents with higher concentration may last longer but are not more effective; against ticks, 20% picaridin may work for 8 hours vs. 55–98.11% DEET for 5–6 hours or 30–40% OLE for 6 hours.[139][143] Repellents should not be used under clothes, on eyes, mouth, wounds or cuts, or on babies younger than 2 months (3 years for OLE or PMD).[139][134] If sunscreen is used, repellent should be applied on top of it.[139] Repellents should not be sprayed directly on a face, but should instead be sprayed on a hand and then rubbed on the face.[139]

After coming indoors, clothes, gear and pets should be checked for ticks.[134] Clothes can be put into a hot dryer for 10 minutes to kill ticks (just washing or warm dryer are not enough).[134] Showering as soon as possible, looking for ticks over the entire body, and removing them reduce risk of infection.[134] Unfed tick nymphs are the size of a poppy seed, but a day or two after biting and attaching themselves to a person, they look like a small blood blister.[145] The following areas should be checked especially carefully: armpits, between legs, back of knee, bellybutton, trunk, and in children ears, neck and hair.[134]

Tick removal

Removal of a tick using tweezers

Attached ticks should be removed promptly. Risk of infection increases with time of attachment, but in North America risk of Lyme disease is small if the tick is removed within 36 hours.[146] CDC recommends inserting a fine-tipped tweezer between the skin and the tick, grasping very firmly, and pulling the closed tweezer straight away from the skin without twisting, jerking, squeezing or crushing the tick.[147] After tick removal, any tick parts remaining in the skin should be removed with a clean tweezer, if possible.[147] The wound and hands should then be cleaned with alcohol or soap and water.[147] The tick may be disposed by placing it in a container with alcohol, sealed bag, tape or flushed down the toilet.[147] The bitten person should write down where and when the bite happened so that this can be informed to a doctor if the person gets a rash or flu-like symptoms in the following several weeks.[147] CDC recommends not using fingers, nail polish, petroleum jelly or heat on the tick to try to remove it.[147]

In Australia, where the Australian paralysis tick is prevalent, the Australasian Society of Clinical Immunology and Allergy recommends not using tweezers to remove ticks, because if the person is allergic, anaphylaxis could result.[148] Instead, a product should be sprayed on the tick to cause it to freeze and then drop off.[148] Another method consists in using about 20 cm of dental floss or fishing line for slowly tying an overhand knot between the skin and the tick and then pulling it away from the skin.[149][150]

Preventive antibiotics

The risk of infectious transmission increases with the duration of tick attachment.[27] It requires between 36 and 48 hours of attachment for the bacteria that causes Lyme to travel from within the tick into its saliva.[27] If a deer tick that is sufficiently likely to be carrying Borrelia is found attached to a person and removed, and if the tick has been attached for 36 hours or is engorged, a single dose of doxycycline administered within the 72 hours after removal may reduce the risk of Lyme disease. It is not generally recommended for all people bitten, as development of infection is rare: about 50 bitten people would have to be treated this way to prevent one case of erythema migrans (i.e. the typical rash found in about 70–80% of people infected).[3][27]

Garden landscaping

Several landscaping practices may reduce the risk of tick bites in residential yards.

acaricides may also be sprayed on it to kill ticks.[151] A sun-exposed tick-safe zone at least 9 ft from the barrier should concentrate human activity on the yard, including any patios, playgrounds and gardening.[151] Materials such as wood decking, concrete, bricks, gravel or woodchips used on the ground under patios and playgrounds would discourage ticks there.[145] An 8-ft-high fence may be added to keep deer away from the tick-safe zone.[151][145]

Occupational exposure

Outdoor workers are at risk of Lyme disease if they work at sites with infected ticks. This includes construction, landscaping, forestry, brush clearing, land surveying, farming, railroad work, oil field work, utility line work, park or wildlife management.

leaf litter are likely to have more ticks. Outdoor workers should be most careful to protect themselves in the late spring and summer when young ticks are most active.[154]

Host animals

Ticks can feed upon the blood of a wide array of possible host species, including

reservoir host in which the pathogen for Lyme disease can survive. Availability of hosts can have significant impacts on the transmission of Lyme disease. A greater diversity of hosts, or of those that don't support the pathogen, tends to decrease the likelihood that the disease will be transmitted.[155]

In the United States, one approach to reducing the incidence of Lyme and other deer tick-borne diseases has been to greatly reduce the deer population on which the adult ticks depend for feeding and reproduction. Lyme disease cases fell following deer eradication on an island, Monhegan, Maine,[156] and following deer control in Mumford Cove, Connecticut.[157] Advocates have suggested reducing the deer population to levels of 8 to 10 deer per square mile, compared to levels of 60 or more deer per square mile in the areas of the country with the highest Lyme disease rates.[158]

Others have noted that while deer are reproductive hosts, they are not Borrelia burgdorferi reservoirs. Researchers have suggested that smaller, less obviously visible Lyme reservoirs, like

Eastern chipmunks, may more strongly impact Lyme disease occurrence. Ecosystem studies in New York state suggest that white-footed mice thrive when forests are broken into smaller isolated chunks of woodland with fewer rodent predators. With more rodents harboring the disease, the odds increase that a tick will feed on a disease-harboring rodent and that someone will pick up a disease-carrying tick in their garden or walking in the woods. Data indicates that the smaller the wooded area, the more ticks it will contain and the likely they are to carry Lyme disease, supporting the idea that deforestation and habitat fragmentation affect ticks, hosts and disease transmission.[155]

Tick-borne diseases are estimated to affect ~80 % of cattle worldwide.[159] They also affect cats, dogs, and other pets. Routine veterinary control of ticks of domestic animals through the use of acaricides has been suggested as a way to reduce exposure of humans to ticks. However, chemical control with acaricides is now criticized on a number of grounds. Ticks appear to develop resistance to acaricides; acaricides are costly; and there are concerns over their toxicity and the potential for chemical residues to affect food and the environment.[160]

In Europe, known reservoirs of Borrelia burgdorferi were 9 small mammals, 7 medium-sized mammals and 16 species of birds (including passerines, sea-birds and pheasants).

Sus scrofa),[162] in which one Rickettsia and three Borrelia species were identified",[162] with high risks of coinfection in roe deer.[165] Nevertheless, in the 2000s, in roe deer in Europe "two species of Rickettsia and two species of Borrelia were identified".[162]

Vaccination

As of 2023[update] no human vaccines for Lyme disease were available.[26] The only human vaccine to advance to market was LYMErix, which was available from 1998, but discontinued in 2002.[166] The vaccine candidate VLA15 was scheduled to start a phase 3 trial in the third quarter of 2022, with other research ongoing. Multiple vaccines are available for the prevention of Lyme disease in dogs.

LYMErix

The vaccine LYMErix was available from 1998 to 2002. The

SmithKline Beecham. In clinical trials involving more than 10,000 people, the vaccine was found to confer protective immunity to Lyme disease in 76% of adults after three doses with only mild or moderate and transient adverse effects.[167][168] On 21 December 1998, the Food and Drug Administration (FDA) approved LYMErix on the basis of these trials for persons of ages 15 through 70.[168][166]

Following approval of the

GlaxoSmithKline, alleging the vaccine had caused these health problems. These claims were investigated by the FDA and the Centers for Disease Control, which found no connection between the vaccine and the autoimmune complaints.[170]

Despite the lack of evidence that the complaints were caused by the vaccine, sales plummeted and LYMErix was withdrawn from the U.S. market by GlaxoSmithKline in February 2002,

Max Planck Institute told Nature: "This just shows how irrational the world can be ... There was no scientific justification for the first OspA vaccine LYMErix being pulled."[170][174]

VLA15

The hexavalent (OspA) protein subunit-based vaccine candidate VLA15 was developed by

Valneva. It was granted fast track designation by the U.S. Food and Drug Administration in July 2017.[175][176] In April 2020 Pfizer paid $130 million for the rights to the vaccine, and the companies are developing it together, performing multiple phase 2 trials.[177]

A phase 3 trial of VLA15 was scheduled for late 2022, recruiting volunteers at test sites located across the northeastern United States and in Europe.[178][179] Participants were scheduled to receive an initial three-dose series of vaccines over the course of five to nine months, followed by a booster dose after twelve months, with both the initial series and the booster dose scheduled to be complete before the year's peak Lyme disease season.[179]

Other research

An mRNA vaccine designed to cause a strong fast immune response to tick saliva allowed the immune system to detect and remove the ticks from test animals before they were able to transmit the infectious bacteria.[180] The vaccine contains mRNAs for the body to build 19 proteins in tick saliva which, by enabling quick development of erythema (itchy redness) at the bite site, protects guinea pigs against Lyme disease. It also protected the test animals if the tick is not removed if only one tick, but not three, remain attached.[181][182]

Canine vaccines

Merial, generates antibodies against the OspA protein so a tick feeding on a vaccinated dog draws in blood full of anti-OspA antibodies, which kill the spirochetes in the tick's gut before they are transmitted to the dog.[183]

Treatment

facial palsy, radiculopathy, meningitis, or peripheral neuropathy.[27] Intravenous administration of ceftriaxone is recommended as the first choice in these cases;[27] cefotaxime and doxycycline are available as alternatives.[27]

Treatment regimens for Lyme disease range from 14 days in early localized disease, to 14–21 days in early disseminated disease to 14–28 days in late disseminated disease.[184] Neurologic complications of Lyme disease may be treated with doxycycline as it can be taken by mouth and has a lower cost, although in North America evidence of efficacy is only indirect.[119] In case of failure, guidelines recommend retreatment with injectable ceftriaxone.[119] Several months after treatment for Lyme arthritis, if joint swelling persists or returns, a second round of antibiotics may be considered; intravenous antibiotics are preferred for retreatment in case of poor response to oral antibiotics.[27][34] Outside of that, a prolonged antibiotic regimen lasting more than 28 days is not recommended as no evidence shows it to be effective.[27][185] IgM and IgG antibody levels may be elevated for years even after successful treatment with antibiotics.[27] As antibody levels are not indicative of treatment success, testing for them is not recommended.[27]

Facial palsy may resolve without treatment; however, antibiotic treatment is recommended to stop other Lyme complications.[34] Corticosteroids are not recommended when facial palsy is caused by Lyme disease.[43] In those with facial palsy, frequent use of artificial tears while awake is recommended, along with ointment and a patch or taping the eye closed when sleeping.[43][186]

About a third of people with Lyme carditis need a temporary pacemaker until their heart conduction abnormality resolves, and 21% need to be hospitalized.[45] Lyme carditis should not be treated with corticosteroids.[45]

People with Lyme arthritis should limit their level of physical activity to avoid damaging affected joints, and in case of limping should use crutches.

disease-modifying antirheumatic drugs (DMARDs), arthroscopic synovectomy, or physical therapy.[54][187]

People receiving treatment should be advised that reinfection is possible and how to prevent it.[114]

Prognosis

Lyme disease's typical first sign, the erythema migrans (EM) rash, resolves within several weeks even without treatment.[3] However, in untreated people, the infection often disseminates to the nervous system, heart, or joints, possibly causing permanent damage to body tissues.[34]

People who receive recommended antibiotic treatment within several days of appearance of an initial EM rash have the best prospects.[112] Recovery may not be total or immediate. The percentage of people achieving full recovery in the United States increases from about 64–71% at end of treatment for EM rash to about 84–90% after 30 months; higher percentages are reported in Europe.[188][189] Treatment failure, i.e. persistence of original or appearance of new signs of the disease, occurs only in a few people.[188] Remaining people are considered cured but continue to experience subjective symptoms, e.g. joint or muscle pains or fatigue.[190] These symptoms usually are mild and nondisabling.[190]

People treated only after nervous system manifestations of the disease may end up with objective neurological deficits, in addition to subjective symptoms.[34] In Europe, an average of 32–33 months after initial Lyme symptoms in people treated mostly with doxycycline 200 mg for 14–21 days, the percentage of people with lingering symptoms was much higher among those diagnosed with neuroborreliosis (50%) than among those with only an EM rash (16%).[191] In another European study, 5 years after treatment for neuroborreliosis, lingering symptoms were less common among children (15%) than adults (30%), and in the latter was less common among those treated within 30 days of the first symptom (16%) than among those treated later (39%); among those with lingering symptoms, 54% had daily activities restricted and 19% were on sick leave or incapacitated.[192]

Some data suggest that about 90% of Lyme

facial palsies treated with antibiotics recover fully a median of 24 days after appearing and most of the rest recover with only mild abnormality.[193][194] However, in Europe 41% of people treated for facial palsy had other lingering symptoms at followup up to 6 months later, including 28% with numbness or altered sensation and 14% with fatigue or concentration problems.[194] Palsies in both sides of the face are associated with worse and longer time to recovery.[193][194] Historical data suggests that untreated people with facial palsies recover at nearly the same rate, but 88% subsequently have Lyme arthritis.[193][195] Other research shows that synkinesis (involuntary movement of a facial muscle when another one is voluntarily moved) can become evident only 6–12 months after facial palsy appears to be resolved, as damaged nerves regrow and sometimes connect to incorrect muscles.[196] Synkinesis is associated with corticosteroid use.[196] In longer-term follow-up, 16–23% of Lyme facial palsies do not fully recover.[196]

In Europe, about a quarter of people with

facial palsy and other impaired movement.[42]

Recovery from late neuroborreliosis tends to take longer and be less complete than from early neuroborreliosis, probably because of irreversible neurologic damage.[34]

About half the people with Lyme carditis progress to complete heart block, but it usually resolves in a week.[45] Other Lyme heart conduction abnormalities resolve typically within 6 weeks.[45] About 94% of people have full recovery, but 5% need a permanent pacemaker and 1% end up with persistent heart block (the actual percentage may be higher because of unrecognized cases).[45] Lyme myocardial complications usually are mild and self-limiting.[45] However, in some cases Lyme carditis can be fatal.[45]

Recommended antibiotic treatments are effective in about 90% of Lyme arthritis cases, although it can take several months for inflammation to resolve and a second round of antibiotics is often necessary.

DMARDs or synovectomy can accelerate recovery.[187]

Reinfection is not uncommon. In a U.S. study, 6–11% of people treated for an EM rash had another EM rash within 30 months.[188] The second rash typically is due to infection by a different Borrelia strain.[197]

Post-treatment Lyme disease syndrome

Chronic symptoms like pain, fatigue, or cognitive impairment are experienced by 10–20% of people who contract Lyme disease, even after completing treatment. This is called Post-treatment Lyme disease syndrome, or PTLDS.[198][199]

The cause is unknown. One hypothesis is that a persistent, difficult-to-detect infection remains. Work with mice, dogs, and non-human primates have shown evidence of persistent B. burgdorferi, although these remaining bacteria are hard to cultivate and Koch's postulates are hard to prove. Another hypothesis is that autoimmunity has been triggered by the infection. Auto–immune responses are known to occur following other infections, including Campylobacter (

Guillain-Barré syndrome), Chlamydia (reactive arthritis), and strep throat (rheumatic heart disease). A third hypothesis is that symptoms are simply unrelated to the previous Lyme infection.[199][200]

There is no proven treatment for Post-treatment Lyme disease syndrome. While short-term antibiotics are effective in early Lyme disease, prolonged antibiotics are not. They have been shown ineffective in placebo-controlled trials and carry the risk of serious, sometimes deadly complications. Generally, treatment is symptomatic and is similar to the management of

ME/CFS. PTLDS usually gets better over time, but recovery may take many months.[199]

Epidemiology

Countries with reported Lyme disease cases

Lyme disease occurs regularly in Northern Hemisphere temperate regions.[201] An estimated 476,000 people a year are diagnosed and treated for the disease in the United States. This number is likely an overestimate due to overdiagnosis and overtreatment.[5][6] Over 200,000 people a year are diagnosed and treated in Europe.[7][3][202] There is a suggestion that tick populations and Lyme disease occurrence are increasing and spreading into new areas, due in part to the warming temperatures of climate change. However, tick-borne disease systems are complex, and determining whether changes are due to climate change or other drivers can be difficult.[155][203] Lyme disease effects are comparable among males and females. A wide range of age groups is affected, though the number of cases is highest among 10- to 19-year-olds.

Africa

In northern Africa, B. burgdorferi sensu lato has been identified in Morocco, Algeria, Egypt and Tunisia.[204][205][206]

Lyme disease in sub-Saharan Africa is presently unknown, but evidence indicates it may occur in humans in this region. The abundance of hosts and tick vectors would favor the establishment of Lyme infection in Africa.[207] In East Africa, two cases of Lyme disease have been reported in Kenya.[208] According The Federation of Infectious Diseases Societies of Southern Africa, Lyme disease is not known to be endemic in either South Africa or Mozambique.[209]

Asia

B. burgdorferi sensu lato-infested ticks are being found more frequently in Japan, as well as in northwest China, Nepal, Thailand and far eastern Russia.[210][211] Borrelia has also been isolated in Mongolia.[212]

Australia

Lyme disease is not considered endemic to Australia.[213] While there have been reports of people acquiring Lyme disease in Australia, and even evidence of closely related Borrelia species in ticks,[214] the evidence linking these cases to local transmission is limited. Ongoing research on resolving potential Borrelia species to Debilitating Symptom Complexes Attributed to Ticks (DSCATT) in Australia are ongoing.[215]

Europe

In Europe, Lyme disease is caused by infection with one or more pathogenic European genospecies of the spirochaete B. burgdorferi sensu lato, mainly transmitted by the tick Ixodes ricinus.[216] Cases of B. burgdorferi sensu lato-infected ticks are found predominantly in central Europe, particularly in Slovenia and Austria, but have been isolated in almost every country on the continent.[217] Number of cases in southern Europe, such as Italy and Portugal, is much lower.[218] Diagnosed cases in some Western countries, such as Iceland, are rising.[219] Lyme disease is rare in Iceland. On average around 6 to 7 cases are diagnosed every year, primarily localised infections presenting as erythema migrans. None of the cases had a definitive Icelandic origin and the yearly number of cases has not been increasing.[220]

United Kingdom

In the United Kingdom the number of laboratory-confirmed cases of Lyme disease has been rising steadily since voluntary reporting was introduced in 1986[221] when 68 cases were recorded in the UK and Ireland combined.[222] In the UK there were 23 confirmed cases in 1988 and 19 in 1990,[223] but 973 in 2009[221] and 953 in 2010.[224] Provisional figures for the first 3 quarters of 2011 show a 26% increase on the same period in 2010.[225]

It is thought, however, that the actual number of cases is significantly higher than suggested by the above figures, with the UK's Health Protection Agency estimating that there are between 2,000 and 3,000 cases per year,[224] (with an average of around 15% of the infections acquired overseas[221]), while Dr Darrel Ho-Yen, Director of the Scottish Toxoplasma Reference Laboratory and National Lyme Disease Testing Service, believes that the number of confirmed cases should be multiplied by 10 "to take account of wrongly diagnosed cases, tests giving false results, sufferers who weren't tested, people who are infected but not showing symptoms, failures to notify and infected individuals who don't consult a doctor."[226][227]

Despite Lyme disease (Borrelia burgdorferi infection) being a notifiable disease in Scotland[228] since January 1990[229] which should therefore be reported on the basis of clinical suspicion, it is believed that many GPs are unaware of the requirement.[230] Mandatory reporting, limited to laboratory test results only, was introduced throughout the UK in October 2010, under the Health Protection (Notification) Regulations 2010.[221]

Although there is a greater number of cases of Lyme disease in the

seropositive, as were between 2% and 4–5% of the general local population of the area.[234][235]

Tests on pet dogs carried out throughout the country in 2009 indicated that around 2.5% of ticks in the UK may be infected, considerably higher than previously thought.

global warming may lead to an increase in tick activity in the future, as well as an increase in the amount of time that people spend in public parks, thus increasing the risk of infection.[238]
However no published research has proven this to be so.

North America

Many studies in North America have examined ecological and environmental correlates of the number of people affected by Lyme disease. A 2005 study using climate suitability modelling of I. scapularis projected that climate change would cause an overall 213% increase in suitable vector habitat by 2080, with northward expansions in Canada, increased suitability in the central U.S., and decreased suitable habitat and vector retraction in the southern U.S.[239] A 2008 review of published studies concluded that the presence of forests or forested areas was the only variable that consistently elevated the risk of Lyme disease whereas other environmental variables showed little or no concordance between studies.[240] The authors argued that the factors influencing tick density and human risk between sites are still poorly understood, and that future studies should be conducted over longer time periods, become more standardized across regions, and incorporate existing knowledge of regional Lyme disease ecology.[240]

Canada

The range of ticks able to carry Lyme disease has expanded from a limited area of Ontario to include areas of southern Quebec, Manitoba, northern Ontario, southern New Brunswick, southwest Nova Scotia and limited parts of Saskatchewan and Alberta, as well as British Columbia. Cases have been reported as far east as the island of Newfoundland.[111][241][242][243] A model-based prediction by Leighton et al. (2012) suggests that the range of the I. scapularis tick will expand into Canada by 46 km/year over the next decade, with warming climatic temperatures as the main driver of increased speed of spread.[244]

Mexico

A 2007 study suggests Borrelia burgdorferi infections are endemic to Mexico, from four cases reported between 1999 and 2000.[245]

United States

Northeast Megalopolis and western Wisconsin

Lyme disease is the most common tick-borne disease in North America and Europe, and one of the fastest-growing infectious diseases in the United States. Of cases reported to the United States CDC, the ratio of Lyme disease infection is 7.9 cases for every 100,000 persons. In the ten states where Lyme disease is most common, the average was 31.6 cases for every 100,000 persons for the year 2005.[246][247][248]

Although Lyme disease has been reported in all states due to travel-associated infections, about 99% of all reported cases are confined to just five geographic areas (New England, Mid-Atlantic, East-North Central, South Atlantic, and West North-Central).[89][249][250] CDC implemented national surveillance of Lyme disease cases in 1991. Since then, reporting criteria has been modified multiple times.[251] The 2022 surveillance case definition classifies cases as confirmed, probable, and suspect.[252] The number of reported cases of the disease has been increasing, as are endemic regions in North America.

The CDC emphasizes that, while surveillance data has limitations, it is useful due to "uniformity, simplicity, and timeliness." While cases are under-reported in high-incidence areas, over-reporting is likely in low-incidence areas. Additionally, surveillance cases are reported by county of residence and not where an infection was necessarily contracted.[253][89]

Several similar but apparently distinct conditions may exist, caused by various species or subspecies of Borrelia in North America. A regionally restricted condition that may be related to Borrelia infection is southern tick-associated rash illness (STARI), also known as Masters disease. Amblyomma americanum, known commonly as the lone-star tick, is recognized as the primary vector for STARI. In some parts of the geographical distribution of STARI, Lyme disease is quite rare (e.g., Arkansas), so people in these regions experiencing Lyme-like symptoms—especially if they follow a bite from a lone-star tick—should consider STARI as a possibility. It is generally a milder condition than Lyme and typically responds well to antibiotic treatment.[254]

In recent years there have been 5 to 10 cases a year of a disease similar to Lyme occurring in Montana. It occurs primarily in pockets along the Yellowstone River in central Montana. People have developed a red bull's-eye rash around a tick bite followed by weeks of fatigue and a fever.[250]

South America

In Brazil, a Lyme-like disease known as Baggio–Yoshinari syndrome was identified, caused by microorganisms that do not belong to the B. burgdorferi sensu lato complex and transmitted by ticks of the Amblyomma and Rhipicephalus genera.[255] The first reported case of BYS in Brazil was made in 1992 in Cotia, São Paulo.[256]

Etymology

Lyme disease was diagnosed as a separate condition for the first time in 1975 in Lyme, Connecticut.[257]

History

The evolutionary history of Borrelia burgdorferi genetics has been the subject of recent studies. One study has found that prior to the

mid-west that occurred during the early 19th century, Lyme disease was present for thousands of years in America and had spread along with its tick hosts from the Northeast to the Midwest.[258]

John Josselyn, who visited New England in 1638 and again from 1663 to 1670, wrote "there be infinite numbers of ticks hanging upon the bushes in summertime that will cleave to man's garments and creep into his breeches, eating themselves in a short time into the very flesh of a man. I have seen the stockings of those that have gone through the woods covered with them."[259]

This is also confirmed by the writings of

Peter Kalm, a Swedish botanist who was sent to America by Linnaeus, and who found the forests of New York "abound" with ticks when he visited in 1749. When Kalm's journey was retraced 100 years later, the forests were gone and the Lyme bacterium had probably become isolated to a few pockets along the northeast coast, Wisconsin, and Minnesota.[260]

Perhaps the first detailed description of what is now known as Lyme disease appeared in the writings of John Walker after a visit to the island of Jura (Deer Island) off the west coast of Scotland in 1764.[261] He gives a good description both of the symptoms of Lyme disease (with "exquisite pain [in] the interior parts of the limbs") and of the tick vector itself, which he describes as a "worm" with a body which is "of a reddish color and of a compressed shape with a row of feet on each side" that "penetrates the skin". Many people from this area of Great Britain emigrated to North America between 1717 and the end of the 18th century.[citation needed]

The examination of preserved museum specimens has found Borrelia DNA in an infected

Ötzi the Iceman, a 5,300-year-old mummy, revealed the presence of the DNA sequence of Borrelia burgdorferi making him the earliest known human with Lyme disease.[262]

The early European studies of what is now known as Lyme disease described its skin manifestations. The first study dates to 1883 in

skin disorder now known as acrodermatitis chronica atrophicans.[263]

At a 1909 research conference, Swedish dermatologist

borrelial lymphocytoma was first described in 1911.[264]

The modern history of medical understanding of the disease, including its cause, diagnosis, and treatment, has been difficult.[265]

Neurological problems following tick bites were recognized starting in the 1920s. French physicians Garin and Bujadoux described a farmer with a painful sensory

radiculitis accompanied by mild meningitis following a tick bite. A large, ring-shaped rash was also noted, although the doctors did not relate it to the meningoradiculitis. In 1930, the Swedish dermatologist Sven Hellerström was the first to propose EM and neurological symptoms following a tick bite were related.[266] In the 1940s, German neurologist Alfred Bannwarth
described several cases of chronic lymphocytic meningitis and polyradiculoneuritis, some of which were accompanied by erythematous skin lesions.

Carl Lennhoff, who worked at the Karolinska Institute in Sweden, believed many skin conditions were caused by spirochetes. In 1948, he used a special stain to microscopically observe what he believed were spirochetes in various types of skin lesions, including EM.[267] Although his conclusions were later shown to be erroneous, interest in the study of spirochetes was sparked. In 1949, Nils Thyresson, who also worked at the Karolinska Institute, was the first to treat ACA with penicillin.[268] In the 1950s, the relationship among tick bite, lymphocytoma, EM and Bannwarth's syndrome was recognized throughout Europe leading to the widespread use of penicillin for treatment in Europe.[269][270]

In 1970, a dermatologist in Wisconsin named Rudolph Scrimenti recognized an EM lesion in a person after recalling a paper by Hellerström that had been reprinted in an American science journal in 1950. This was the first documented case of EM in the United States. Based on the European literature, he treated the person with penicillin.[271]

The full

Old Lyme, which gave the disease its popular name.[272] This was investigated by physicians David Snydman and Allen Steere of the Epidemic Intelligence Service, and by others from Yale University, including Stephen Malawista, who is credited as a co-discover of the disease.[273] The recognition that the people in the United States had EM led to the recognition that "Lyme arthritis" was one manifestation of the same tick-borne condition known in Europe.[274]

Before 1976, the elements of B. burgdorferi sensu lato infection were called or known as tick-borne meningopolyneuritis, Garin-Bujadoux syndrome, Bannwarth syndrome, Afzelius's disease,[275] Montauk Knee or sheep tick fever. Since 1976 the disease is most often referred to as Lyme disease,[276][277] Lyme borreliosis or simply borreliosis.[278][279]

In 1980, Steere, et al., began to test

sera from people diagnosed with Lyme disease. University of Texas Health Science Center researcher Alan Barbour "offered his expertise to culture and immunochemically characterize the organism." Burgdorfer subsequently confirmed his discovery by isolating, from people with Lyme disease, spirochetes identical to those found in ticks.[281] In June 1982, he published his findings in Science, and the spirochete was named Borrelia burgdorferi in his honor.[282]

After the identification of B. burgdorferi as the causative agent of Lyme disease, antibiotics were selected for testing, guided by in vitro antibiotic sensitivities, including tetracycline antibiotics, amoxicillin, cefuroxime axetil, intravenous and intramuscular penicillin and intravenous ceftriaxone.[283][284] The mechanism of tick transmission was also the subject of much discussion. B. burgdorferi spirochetes were identified in tick saliva in 1987, confirming the hypothesis that transmission occurred via tick salivary glands.[285]

Society, culture, & controversy

Landscape changes & urbanization

Urbanization and other

global warming and the spread of vector-borne diseases, including Lyme disease.[288]

The dilution effect

Given these habitat-host dynamics, some researchers have begun to postulate whether the dilution effect could mitigate the spread of Lyme disease.[286] The dilution effect is a hypothesis that predicts that an increase in host biodiversity will result in a decrease in the number of vectors infected with B. burgdorferi.[286] Scientific research has shown that nymphal infection prevalence (NIP) decreases as the number of host species increases, supporting the dilution effect.[286] That said, these findings should not be misinterpreted to suggest that there is a direct relationship between decreased NIP and decreased epidemiological risk, as this has yet to be proven.[286] Additionally, it is important to note that, thus far, the dilution effect is only supported in the Northeastern United States, and has been disproved in other parts of the world that also experience high Lyme disease incidence rates [289]

Chronic Lyme disease

Main article: Chronic Lyme disease

The term "chronic Lyme disease" is controversial and not recognized in the medical literature,

non-specific symptoms (such as fatigue, musculoskeletal pain, and cognitive complaints) in a person previously treated for Lyme disease.[292]

The 2008 documentary Under Our Skin is known for promoting controversial and unrecognized theories about "chronic Lyme disease".[293]

Other animals

Dogs

Prevention of Lyme disease is an important step in keeping dogs safe in endemic areas. Prevention education and a number of preventive measures are available. First, for dog owners who live near or who often frequent tick-infested areas, routine vaccinations of their dogs is an important step.[294]

Another crucial preventive measure is the use of persistent acaricides, such as topical repellents or pesticides that contain triazapentadienes (

pyrethroids).[295] These acaricides target primarily the adult stages of Lyme-carrying ticks and reduce the number of reproductively active ticks in the environment.[294] Formulations of these ingredients are available in a variety of topical forms, including spot-ons, sprays, powders, impregnated collars, solutions, and shampoos.[295]

Examination of a dog for ticks after being in a tick-infested area is an important precautionary measure to take in the prevention of Lyme disease. Key spots to examine include the head, neck, and ears.[296]

In dogs, a serious long-term prognosis may result in glomerular disease,[297] which is a category of kidney damage that may cause chronic kidney disease.[183] Dogs may also experience chronic joint disease if the disease is left untreated. However, the majority of cases of Lyme disease in dogs result in complete recovery with, and sometimes without, treatment with antibiotics.[298][verification needed] In rare cases, Lyme disease can be fatal to both humans and dogs.[299]

Cats

Unlike dogs, it is very rare for a cat to be infected with Lyme disease. However, cats are nevertheless capable of being infected with B. burgdorferi , following a bite from an infected tick. Cats who are infected with Lyme Disease may show symptoms including but not limited to lameness, fatigue, or loss of appetite.[300] In two cases, the infected cats experienced cardiac irregularities similar to symptoms of Lyme in both dogs and humans.[301] However, cats who are infected with Lyme disease are likely to be asymptomatic, and show no noticeable signs of the disease.[301][300] Cats with Lyme are often treated with antibiotics, much like other animals. In some cases, additional treatment or therapy may be required.[300]

Horses

While Lyme disease can occur in horses, not every infection with B. burgdorferi is associated with symptoms.[302] Especially, detection of specific antibodies against B. burgdorferi alone is not sufficient for a diagnosis of equine Lyme disease and unspecific testing for antibodies is not recommended.[303]

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Public Domain This article incorporates public domain material from Post-Treatment Lyme Disease Syndrome. Centers for Disease Control and Prevention.

Further reading

External links

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