Lymphotoxin beta receptor

Source: Wikipedia, the free encyclopedia.
LTBR
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Ensembl
UniProt
RefSeq (mRNA)

NM_001270987
NM_002342

NM_010736

RefSeq (protein)

NP_001257916
NP_002333

NP_034866

Location (UCSC)Chr 12: 6.38 – 6.39 MbChr 6: 125.28 – 125.29 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Lymphotoxin beta receptor (LTBR), also known as tumor necrosis factor receptor superfamily member 3 (TNFRSF3), is a

tumor necrosis factor receptor
superfamily.

Function

The protein encoded by this gene is a member of the

myeloid lineages, but not on T and B lymphocytes. The protein specifically binds the lymphotoxin membrane form (a complex of lymphotoxin-alpha and lymphotoxin-beta). The encoded protein and its ligand play a role in the development and organization of lymphoid tissue and transformed cells. Activation of the encoded protein can trigger apoptosis.[5]

Not only does the LTBR help trigger apoptosis, it can lead to the release of the

HEK293 cells increases IL-8 promoter activity and leads to IL-8 release. LTBR is also essential for development and organization of the secondary lymphoid organs and chemokine release.[8]

Structure

The Ramachandran plots show that 64.6% of all residues were in a favored region. This structure was found using X-ray diffraction. The resolution is 3.50 angstroms. The alpha and beta angles are 90 degrees while the gamma angle is 120 degrees.[9]

Interactions

Lymphotoxin beta receptor has been shown to

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000111321 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030339 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: LTBR lymphotoxin beta receptor (TNFR superfamily, member 3)".
  6. PMID 8486360
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  9. ^ "MolProbity Ramachandran analysis" (PDF). Archived from the original (PDF) on 2012-10-12.
  10. PMID 12571250
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Further reading

External links