MAM-2201

Source: Wikipedia, the free encyclopedia.

MAM-2201
Legal status
Legal status
Identifiers
  • (1-(5-Fluoropentyl)-1H-indol-3-yl)(4-methyl-1-naphthalenyl)methanone
JSmol)
  • FCCCCCn(c4)c2ccccc2c4C(=O)c3ccc(C)c1ccccc13
  • InChI=1S/C25H24FNO/c1-18-13-14-22(20-10-4-3-9-19(18)20)25(28)23-17-27(16-8-2-7-15-26)24-12-6-5-11-21(23)24/h3-6,9-14,17H,2,7-8,15-16H2,1H3
  • Key:IGBHZHCGWLHBAE-UHFFFAOYSA-N

MAM-2201 (4'-methyl-AM-2201, 5"-fluoro-JWH-122) is a drug that presumably acts as a potent

synthetic cannabis smoking blends.[4][5][6] Like RCS-4 and AB-001, MAM-2201 thus appears to be a novel compound invented by "research chemical" suppliers specifically for grey-market recreational use. Structurally, MAM-2201 is a hybrid of two known cannabinoid compounds JWH-122 and AM-2201
, both of which had previously been used as active ingredients in synthetic cannabis blends before being banned in many countries.

A study of MAM-2201 in rats showed that it causes neurofunctional disruptions.[7] A later study demonstrated that MAM-2201 bound to and activated human CB1 and CB2 cannabinoid receptors and substituted for THC in THC drug discrimination in mice.[8]

Legal status

In the United States, all CB1 receptor agonists of the 3-(1-naphthoyl)indole class such as MAM-2201 are

Schedule I Controlled Substances.[9]

MAM-2201 has been banned by being added to the temporary class drug schedule in New Zealand, effective from 13 July 2012.[10]

As of October 2015 MAM-2201 is a controlled substance in China.[11]

See also

References

  1. ^ Anvisa (24 July 2023). "RDC Nº 804 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 804 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 25 July 2023). Archived from the original on 27 August 2023. Retrieved 27 August 2023.
  2. S2CID 24905067
    .
  3. PMID 29608249
    .
  4. ^ EMCDDA–Europol 2011 Annual Report on the implementation of Council Decision 2005/387/JHA
  5. PMID 22264627
    .
  6. S2CID 24068469
    .
  7. PMID 26032255
    .
  8. PMID 29113898
    .
  9. ^ 21 U.S.C. § 812: Schedules of controlled substances
  10. ^ Temporary Class Drug Notice, 5 July 2012. NZ Department of Internal Affairs.
  11. ^ "关于印发《非药用类麻醉药品和精神药品列管办法》的通知" (in Chinese). China Food and Drug Administration. 27 September 2015. Retrieved 1 October 2015.
Retrieved from "https://en.wikipedia.org/w/index.php?title=MAM-2201&oldid=1186150544"