MAPK1
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RefSeq (mRNA) | |||||||||
RefSeq (protein) | |||||||||
Location (UCSC) | Chr 22: 21.76 – 21.87 Mb | Chr 16: 16.8 – 16.87 Mb | |||||||
PubMed search | [3] | [4] |
View/Edit Human | View/Edit Mouse |
Mitogen-activated protein kinase 1 (MAPK 1), also known as ERK2, is an enzyme that in humans is encoded by the MAPK1 gene.[5]
Function
The protein encoded by this gene is a member of the
UTRs, have been reported for this gene.[6] MAPK1 contains multiple amino acid sites that are phosphorylated and ubiquitinated.[7]
Interactions
MAPK1 has been shown to
interact
with:
- ADAM17,[8]
- CIITA,[9]
- DUSP1,[10][11]
- DUSP22,[12]
- DUSP3,[13]
- ELK1,[14][15]
- FHL2,[16]
- HDAC4,[17]
- MAP2K1,[18][19][20][21][22][23]
- MAP3K1[24]
- MAPK14,[18][25]
- MKNK1,[26]
- MKNK2,[26][27]
- Myc,[28][29][30]
- NEK2,[31]
- PEA15,[32]
- PTPN7,[33][34]
- Phosphatidylethanolamine binding protein 1,[20]
- RPS6KA1,[14][35][36]
- RPS6KA2,[36][37]
- RPS6KA3,[35][37]
- SORBS3,[38]
- STAT5A,[39][40]
- TNIP1,[41]
- TOB1,[42]
- TSC2,[43]
- UBR5,[14] and
- VAV1.[44][45]
Clinical significance
Mutations in MAPK1 are implicated in many types of cancer.[46]
See also
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000100030 - Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000063358 - Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- PMID 1540184.
- ^ "Entrez Gene: MAPK1 mitogen-activated protein kinase 1".
- ^ "ERK2 (human)". www.phosphosite.org. Retrieved 2020-10-31.
- PMID 12058067.
- PMID 18245089.
- PMID 11278799.
- PMID 18519678.
- PMID 11346645.
- PMID 10224087.
- ^ PMID 12594221.
- PMID 8586671.
- PMID 14729955.
- PMID 11114188.
- ^ PMID 12697810.
- PMID 11823456.
- ^ PMID 10757792.
- PMID 11266467.
- PMID 11352917.
- PMID 11279118.
- PMID 10969079.
- PMID 11157753.
- ^ PMID 9155017.
- PMID 12897141.
- PMID 15210690.
- S2CID 45404088.
- PMID 9207092.
- PMID 15358203.
- PMID 11702783.
- S2CID 24843974.
- PMID 10206983.
- ^ PMID 9915826.
- ^ PMID 12832467.
- ^ PMID 8939914.
- PMID 15184391.
- PMID 10194762.
- S2CID 45725648.
- PMID 12220502.
- PMID 12151396.
- S2CID 18663447.
- PMID 8900182.
- S2CID 32632406.
- ^ "Expression of MAPK1 in cancer - Summary - The Human Protein Atlas". www.proteinatlas.org.
Further reading
- Morishima-Kawashima M, Hasegawa M, Takio K, Suzuki M, Yoshida H, Watanabe A, Titani K, Ihara Y (1995). "Hyperphosphorylation of tau in PHF". Neurobiol. Aging. 16 (3): 365–71, discussion 371–80. S2CID 22471158.
- Jeong Y, Du R, Zhu X, et al. (2014). "Histone deacetylase isoforms regulate innate immune responses by deacetylating mitogen-activated protein kinase phosphatase-1". J Leukoc Biol. 95 (4): 651–9. S2CID 40126163.
- Davis RJ (1995). "Transcriptional regulation by MAP kinases". Mol. Reprod. Dev. 42 (4): 459–67. S2CID 12842112.
- Peruzzi F, Gordon J, Darbinian N, Amini S (2002). "Tat-induced deregulation of neuronal differentiation and survival by nerve growth factor pathway". J. Neurovirol. 8 Suppl 2 (2): 91–6. PMID 12491158.
- Greenway AL, Holloway G, McPhee DA, Ellis P, Cornall A, Lidman M (2003). "HIV-1 Nef control of cell signalling molecules: multiple strategies to promote virus replication". J. Biosci. 28 (3): 323–35. S2CID 33749514.
- Meloche S, Pouysségur J (2007). "The ERK1/2 mitogen-activated protein kinase pathway as a master regulator of the G1- to S-phase transition". Oncogene. 26 (22): 3227–39. S2CID 2245848.
External links
- MAP Kinase Resource Archived 2021-04-15 at the Wayback Machine.