MAPK3
Mitogen-activated protein kinase 3, also known as p44MAPK and ERK1,[5] is an enzyme that in humans is encoded by the MAPK3 gene.[6]
Function
The protein encoded by this gene is a member of the
isoforms have been described.[7]
Clinical significance
It has been suggested that MAPK3, along with the gene
influenza A virus had been made to infect human lung cells.[8]
Signaling pathways
Pharmacological inhibition of ERK1/2 restores
GSK3β activity and protein synthesis levels in a model of tuberous sclerosis.[9]
Interactions
MAPK3 has been shown to
interact
with:
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000102882 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000063065 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- S2CID 205499891.
- PMID 9628824.
- ^ "Entrez Gene: MAPK3 mitogen-activated protein kinase 3".
- PMID 22822053.
- PMID 28646232.
- PMID 10224087.
- PMID 9535927.
- PMID 10648599.
- PMID 11114188.
- ^ PMID 9006895.
- ^ PMID 8626767.
- S2CID 28868990.
- PMID 10748187.
- ^ PMID 8226933.
- PMID 10702794.
- S2CID 40413956.
- PMID 10206983.
- PMID 12832467.
- PMID 8939914.
- PMID 8632909.
Further reading
- Peruzzi F, Gordon J, Darbinian N, Amini S (2002). "Tat-induced deregulation of neuronal differentiation and survival by nerve growth factor pathway". J. Neurovirol. 8 Suppl 2 (2): 91–6. PMID 12491158.
- Meloche S, Pouysségur J (2007). "The ERK1/2 mitogen-activated protein kinase pathway as a master regulator of the G1- to S-phase transition". Oncogene. 26 (22): 3227–39. PMID 17496918.
- Ruscica M, Dozio E, Motta M, Magni P (2007), "Modulatory Actions of Neuropeptide y on Prostate Cancer Growth: Role of MAP Kinase/ERK 1/2 Activatio", Modulatory actions of neuropeptide Y on prostate cancer growth: role of MAP kinase/ERK 1/2 activation, Advances In Experimental Medicine And Biology, vol. 604, Springer, pp. 96–100, PMID 17695723
External links
- MAP Kinase Resource Archived 2021-04-15 at the Wayback Machine.
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