MBL deficiency
| MBL deficiency | |
|---|---|
| Other names | Mannose-binding lectin deficiency |
 | |
| Structure of the MBL2 protein. | |
| Specialty | Immunology |
MBL deficiency or mannose-binding lectin deficiency is an illness that has an impact on immunity. Low levels of mannose-binding lectin, an immune system protein, are present in the blood of those who have this illness. It's unclear if this deficiency increases the risk of recurrent infections in those who are affected.[1]
Signs and symptoms
Specific infection susceptibility has been linked to low MBL levels.
Causes
Mannose-binding lectin deficiency can result from mutations in the
Mechanism
Epidemiology
Depending on the definition of deficiency, MBL deficiency affects 10–30% of individuals, making it one of the most prevalent immune defects.[12]
References
Further reading
- Thiel, S.; Frederiksen, P.D.; Jensenius, J.C. (2006). "Clinical manifestations of mannan-binding lectin deficiency". Molecular Immunology. 43 (1–2). Elsevier BV: 86–96. PMID 16023210.
- Chalmers, James D; McHugh, Brian J; Doherty, Catherine; Smith, Maeve P; Govan, John R; Kilpatrick, David C; Hill, Adam T (2013). "Mannose-binding lectin deficiency and disease severity in non-cystic fibrosis bronchiectasis: a prospective study". The Lancet Respiratory Medicine. 1 (3). Elsevier BV: 224–232. ISSN 2213-2600.