MEAI
Clinical data | |
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Trade names | none |
Other names | 5-MeO-AI; 2,3-Dihydro-5-methoxy-1H-Inden-2-amine |
Routes of administration | Oral |
Legal status | |
Legal status |
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Pharmacokinetic data | |
Bioavailability | high |
Metabolism | acetyl-aminoindandane |
Elimination half-life | non-linear |
Excretion | full |
Identifiers | |
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JSmol) | |
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MEAI (5-methoxy-2-aminoindane or 5-MeO-AI or Chaperon) belongs to the indane family of molecules. Its molecular structure was first mentioned implicitly in a markush structure schema appearing in a patent from 1998.[1] It was later explicitly and pharmacologically described in a peer reviewed paper in 2017 by David Nutt and Ezekiel Golan et al.[2] followed by another in February 2018 which detailed the pharmacokinetics, pharmacodynamics and metabolism of MEAI by Shimshoni, David Nutt, Ezekiel Golan et al.[3] One year later it was studied and reported on in another peer reviewed paper by Halberstadt et al.[4] The aminoindane family of molecules was, perhaps, first chemically described in 1980.[5][6]
MEAI was an early candidate of alcohol replacement drugs that came to market during a late 2010s movement to replace alcohol with less-toxic alternatives spearheaded by British psychopharmacologist David Nutt[7][8][9] rippling to the rest of Europe.[10]
In an act of gonzo journalism, Michael Slezak writing for New Scientist, tried and reported on his experience with MEAI[11] after being provided with it by Dr Zee[12] (Ezekiel Golan) after an interview[11] Golan claimed he invented MEAI and originally intended MEAI to be sold as a legal high but instead indicated plans to work with David Nutt and his company DrugScience to develop MEAI further based on Golan's patents as a "binge behaviour regulator"[13] and "alcoholic beverage substitute".[14]
In 2018, a company named Diet Alcohol Corporation of the Americas (DACOA) began openly marketing an MEAI-based drink called "Pace" for sale in the USA and Canada. Pace was described as a 50ml bottle containing 160mg of MEAI in mineral water. Distribution halted after Health Canada released a warning indicating the substance was considered illegal to market for consumption in Canada due to structural similarity to amphetamine.[15][16] In a December 2018 article by CBC News, Ezekiel Golan (Dr Z/Dr Zee) was interviewed and publicly came out as the "lead scientist" of Pace claiming "tens of thousands" of bottles were already sold in Canada.[17] Golan claimed the MEAI featured in Pace was "manufactured in India" and "bottled in Delaware".[17] Health Canada provided a statement to CBC News stating "Pace is an illegal and unauthorized product in Canada." Both Chemistry World[18] and The BBC have dubbed Ezekiel Golan as "the man who invents legal highs".[19] The Guardian called him "the godfather of legal highs"[20] for his contribution in reintroducing substituted cathinone based drugs commonly sold as Bath salts (drug) including Mephedrone
On May 26, 2022, MEAI was prepared for
See also
References
- ^ US 5708018, Haadsma-Svensson SR, Andersson BR, Sonesson CA, Lin CH, Waters RN, Svensson KA, Carlsson PA, Hansson LO, Stjernlof NP, "2-aminoindans as selective dopamine D3 ligands", published 1998-01-13, assigned to Pharmacia & Upjohn Co.
- S2CID 205304106.
- S2CID 3879333.
- PMID 30904940.
- PMID 21748859.
- PMID 7190613.
- ^ Nutt D (23 October 2013). "Decision making about illegal drugs: time for science to take the lead". Nobel Forum, Karolinska Institutet – via YouTube.
- S2CID 5667719.
- ^ Forster K (24 September 2016). "Hangover free alcohol is finally here". The Independent. Retrieved 25 March 2022.
- ^ Wermter B (29 April 2019). "Rauschmittel und gesellschaftliche Probleme" [Drug related societal issues]. Benedict Wermter (in German).
- ^ a b Slezak M (30 December 2014). "High and dry? Party drug could target excess drinking". New Scientist. Retrieved 2022-10-16.
- ^ Slezak M (9 August 2014). "An Interview with Dr Z" (PDF). New Scientist. pp. 1–3. Retrieved 16 October 2022.
- ^ US 10406123B2, Golan E, "Binge behavior regulators", issued 2019-09-10
- ^ US 20170360067, Golan E, "Alcoholic beverage substitutes", issued 2017-12-21
- ^ "Advisory - Health Canada warns consumers that Pace, promoted as an alcohol substitute, is unauthorized and may pose serious health risks". Health Canada. 21 December 2018 – via CISION.
- ^ Brunet J (24 April 2019). "FACT CHECK: Is Pace, an "Alcohol Alternative," Legal in Canada?". The Walrus. Toronto, Ontario.
- ^ a b Wright J (8 December 2018). "Is this drink really a new 'alcohol alternative'?". Information Morning Saint John. pp. All. Retrieved 15 October 2022.
- ^ Extance A (6 September 2017). "The rising tide of 'legal highs'". Chemistry World. Retrieved 2022-10-17.
- ^ "Meet Dr. Zee - the man who invented legal highs". BBC. 23 January 2018.
- TheGuardian.com.
- ^ "Clearmind Medicine". www.clearmindmedicine.com.
- ^ "Clearmind Medicine Inc". CSE:CMND.
- ^ וינרב, גלי (16 February 2022). "החברה שמנסה להפוך סם פסיכדלי למוצר נגד התמכרות" [The company trying to turn a psychedelic drug into an anti-addiction product]. Globes (in Hebrew).
- ^ US 10137096, Golan E, "Binge behavior regulators", published 2018-11-27
- ^ EP 3230256, Golan E, "Alcoholic beverage substitutes", published 2019-11-13
- ^ EP 3230255, Golan E, "Binge behavior regulators", published 2017-10-18
- ^ "The Science and IP Behind our Treatments". Clearmind.
- ^ "Clearmind Medicine". www.clearmindmedicine.com.
- ^ "Clearmind Medicine". www.clearmindmedicine.com. Retrieved 14 August 2022.
- ^ "Clearmind Medicine". www.clearmindmedicine.com. Retrieved 2022-10-16.