MODY 1
| MODY 1 | |
|---|---|
 | |
| This condition is inherited via autosomal dominant manner |
MODY 1 or HNF4A-MODY is a form of
MODY 1 is due to a loss-of-function mutation in the
Although pancreatic beta cells produce adequate insulin in infancy, the capacity for insulin production declines thereafter. Diabetes (persistent hyperglycemia) typically develops by early adult years, but may not appear until later decades. The degree of insulin deficiency is slowly progressive. Many patients with MODY 1 are treated with sulfonylureas for years before insulin is required.
Liver effects are subtle and not clinically significant. Many people with this condition have low levels of
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External links
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