Source: Wikipedia, the free encyclopedia.
Protein-coding gene in the species Homo sapiens
MST1R Available structures Gene ontology
Molecular function Cellular component Biological process Sources:Amigo / QuickGO
Wikidata
Macrophage-stimulating protein receptor is a
c-MET receptor tyrosine kinase.
[5] [7] Interactions MST1R has been shown to
References Further reading
Li BQ, Wang MH, Kung HF, et al. (1995). "Macrophage-stimulating protein activates Ras by both activation and translocation of SOS nucleotide exchange factor" . Biochem. Biophys. Res. Commun . 216 (1): 110–8. . Wang MH, Ronsin C, Gesnel MC, et al. (1994). "Identification of the ron gene product as the receptor for the human macrophage stimulating protein". Science . 266 (5182): 117–9. . Gaudino G, Follenzi A, Naldini L, et al. (1994). "RON is a heterodimeric tyrosine kinase receptor activated by the HGF homologue MSP" . EMBO J . 13 (15): 3524–32. . Lee ST, Strunk KM, Spritz RA (1993). "A survey of protein tyrosine kinase mRNAs expressed in normal human melanocytes". Oncogene . 8 (12): 3403–10. . Collesi C, Santoro MM, Gaudino G, Comoglio PM (1996). "A splicing variant of the RON transcript induces constitutive tyrosine kinase activity and an invasive phenotype" . Mol. Cell. Biol . 16 (10): 5518–26. . Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery" . Genome Res . 6 (9): 791–806. . Iwama A, Yamaguchi N, Suda T (1997). "STK/RON receptor tyrosine kinase mediates both apoptotic and growth signals via the multifunctional docking site conserved among the HGF receptor family" . EMBO J . 15 (21): 5866–75. . Sakamoto O, Iwama A, Amitani R, et al. (1997). "Role of macrophage-stimulating protein and its receptor, RON tyrosine kinase, in ciliary motility" . J. Clin. Invest . 99 (4): 701–9. . Follenzi A, Bakovic S, Gual P, et al. (2000). "Cross-talk between the proto-oncogenes Met and Ron" . Oncogene . 19 (27): 3041–9. . Chen YQ, Zhou YQ, Fisher JH, Wang MH (2002). "Targeted expression of the receptor tyrosine kinase RON in distal lung epithelial cells results in multiple tumor formation: oncogenic potential of RON in vivo" . Oncogene . 21 (41): 6382–6. . Chen YQ, Zhou YQ, Fu LH, et al. (2002). "Multiple pulmonary adenomas in the lung of transgenic mice overexpressing the RON receptor tyrosine kinase. Recepteur d'origine nantais" . Carcinogenesis . 23 (11): 1811–9. . Zhou YQ, He C, Chen YQ, et al. (2003). "Altered expression of the RON receptor tyrosine kinase in primary human colorectal adenocarcinomas: generation of different splicing RON variants and their oncogenic potential" . Oncogene . 22 (2): 186–97. . Danilkovitch-Miagkova A, Duh FM, Kuzmin I, et al. (2003). "Hyaluronidase 2 negatively regulates RON receptor tyrosine kinase and mediates transformation of epithelial cells by jaagsiekte sheep retrovirus" . Proc. Natl. Acad. Sci. U.S.A . 100 (8): 4580–5. . Rampino T, Gregorini M, Soccio G, et al. (2003). "The Ron proto-oncogene product is a phenotypic marker of renal oncocytoma". Am. J. Surg. Pathol . 27 (6): 779–85. . Penengo L, Rubin C, Yarden Y, Gaudino G (2003). "c-Cbl is a critical modulator of the Ron tyrosine kinase receptor" . Oncogene . 22 (24): 3669–79. . Maggiora P, Lorenzato A, Fracchioli S, et al. (2003). "The RON and MET oncogenes are co-expressed in human ovarian carcinomas and cooperate in activating invasiveness". Exp. Cell Res . 288 (2): 382–9. . Santoro MM, Gaudino G, Marchisio PC (2003). "The MSP receptor regulates alpha6beta4 and alpha3beta1 integrins via 14-3-3 proteins in keratinocyte migration" . Dev. Cell . 5 (2): 257–71. . Angeloni D, Danilkovitch-Miagkova A, Miagkov A, et al. (2004). "The soluble sema domain of the RON receptor inhibits macrophage-stimulating protein-induced receptor activation" . J. Biol. Chem . 279 (5): 3726–32. . van den Akker E, van Dijk T, Parren-van Amelsvoort M, et al. (2004). "Tyrosine kinase receptor RON functions downstream of the erythropoietin receptor to induce expansion of erythroid progenitors" . Blood . 103 (12): 4457–65. . Raeppel S, Gaudette G, et al. (2010). "Identification of a novel series of potent RON receptor tyrosine kinase inhibitors". Bioorg. Med. Chem. Lett . 20 (9): 2745–9. .
