MYF6

MYF6
Identifiers
Gene ontology
Molecular function	DNA binding protein dimerization activity DNA-binding transcription factor activity DNA-binding transcription activator activity, RNA polymerase II-specific RNA polymerase II cis-regulatory region sequence-specific DNA binding E-box binding protein heterodimerization activity transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding DNA-binding transcription factor activity, RNA polymerase II-specific
Cellular component	nucleoplasm RNA polymerase II transcription regulator complex nucleus
Biological process	somitogenesis cell differentiation regulation of transcription, DNA-templated positive regulation of muscle cell differentiation regulation of transcription by RNA polymerase II muscle cell fate commitment muscle organ development transcription by RNA polymerase II positive regulation of skeletal muscle fiber development multicellular organism development positive regulation of transcription, DNA-templated positive regulation of myoblast fusion skeletal muscle tissue regeneration positive regulation of myoblast differentiation muscle tissue morphogenesis skeletal muscle cell differentiation negative regulation of transcription, DNA-templated skeletal muscle tissue development positive regulation of transcription by RNA polymerase II
Sources:Amigo / QuickGO

Ensembl				ENSG00000111046	ENSMUSG00000035923
UniProt	P23409	P15375
RefSeq (mRNA)	NM_002469	NM_008657
RefSeq (protein)	NP_002460	NP_032683
Location (UCSC)	Chr 12: 80.71 – 80.71 Mb	Chr 10: 107.33 – 107.33 Mb
PubMed search	[3]	[4]

Wikidata

View/Edit Human

View/Edit Mouse

Myogenic factor 6 (also known as Mrf4 or herculin) is a protein that in humans is encoded by the MYF6 gene. ^[5] This gene is also known in the biomedical literature as MRF4 and herculin. MYF6 is a

Function

MYF6/Mrf4 is a member of the

. MYF6 is a gene that encodes a protein involved in the regulation of myogenesis. The precise role(s) of Myf6/Mrf4 in myogenesis are unclear, although in mice it is able to initiate myogenesis in the absence of Myf5 and MyoD, two other MRFs.^[8] The portion of the protein integral to myogenesis regulation requires the basic helix-loop-helix (bHLH) domain that is conserved among all of the genes in the MRF family.

MYF6 is expressed exclusively in skeletal muscle, and it is expressed at a higher levels in adult skeletal muscle than all of the other MRF family genes. In mouse, Myf6/Mrf4 differs somewhat from the other MRF genes due to its two-phase expression. Initially, Myf6 is transiently expressed along with

The MYF6 gene is physically linked to the MYF5 gene on chromosome 12, and similar linkage is observed in all vertebrates. Mutations in the mouse Myf6 gene typically exhibit reduced levels of Myf5.[10] Despite reductions in muscle mass of the back and defective rib formation, Myf6 mutants still exhibit fairly normal skeletal muscle. This demonstrates that Myf6 is not essential for the formation of most myofibers, at least in the strains of mice tested.

In zebrafish, Myf6/Mrf4 is expressed in all terminally differentiated muscle examined, but expression has not been reported in muscle precursor cells.^[11]

Clinical significance

Mutations in the MYF6 gene are associated with autosomal dominant

References

Further reading

• Braun, T.; Arnold, H. H. (1991). "The four human muscle regulatory helix-loop-helix proteins Myf3-Myf6 exhibit similar hetero-dimerization and DNA binding properties". Nucleic Acids Research. 19 (20): 5645–5651.
  PMID 1945842
  .
• Langlands, K.; Yin, X.; Anand, G.; Prochownik, E. V. (1997). "Differential interactions of Id proteins with basic-helix-loop-helix transcription factors". The Journal of Biological Chemistry. 272 (32): 19785–19793.
  PMID 9242638
  .
• Kong, Y.; Flick, M. J.; Kudla, A. J.; Konieczny, S. F. (1997). "Muscle LIM protein promotes myogenesis by enhancing the activity of MyoD". Molecular and Cellular Biology. 17 (8): 4750–4760.
  PMID 9234731
  .
• Onions, J.; Hermann, S.; Grundström, T. (2000). "A novel type of calmodulin interaction in the inhibition of basic helix-loop-helix transcription factors". Biochemistry. 39 (15): 4366–4374.
  PMID 10757985
  .
• Cupelli, L.; Renault, B.; Leblanc-Straceski, J.; Banks, A.; Ward, D.; Kucherlapati, R. S.; Krauter, K. (1996). "Assignment of the human myogenic factors 5 and 6 (MYF5, MYF6) gene cluster to 12q21 by in situ hybridization and physical mapping of the locus between D12S350 and D12S106". Cytogenetics and Cell Genetics. 72 (2–3): 250–251.
  PMID 8978788
  .
• Kosek, D. J.; Kim, J. S.; Petrella, J. K.; Cross, J. M.; Bamman, M. M. (2006). "Efficacy of 3 days/wk resistance training on myofiber hypertrophy and myogenic mechanisms in young vs. Older adults". Journal of Applied Physiology. 101 (2): 531–544.
  PMID 16614355
  .
• Black, B. L.; Molkentin, J. D.; Olson, E. N. (1998). "Multiple roles for the MyoD basic region in transmission of transcriptional activation signals and interaction with MEF2". Molecular and Cellular Biology. 18 (1): 69–77.
  PMID 9418854
  .
• Braun, T.; Bober, E.; Winter, B.; Rosenthal, N.; Arnold, H. H. (1990). "Myf-6, a new member of the human gene family of myogenic determination factors: Evidence for a gene cluster on chromosome 12". The EMBO Journal. 9 (3): 821–831.
  PMID 2311584
  .
• Kerst, B.; Mennerich, D.; Schuelke, M.; Stoltenburg-Didinger, G.; Von Moers, A.; Gossrau, R.; Van Landeghem, F. K.; Speer, A.; Braun, T.; Hübner, C. (2000). "Heterozygous myogenic factor 6 mutation associated with myopathy and severe course of Becker muscular dystrophy". Neuromuscular Disorders. 10 (8): 572–577.
  S2CID 29535555
  .

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 12 is a stub. You can help Wikipedia by expanding it.

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