Macrophage colony-stimulating factor
The colony stimulating factor 1 (CSF1), also known as macrophage colony-stimulating factor (M-CSF), is a secreted
macrophages or other related cell types. Eukaryotic cells also produce M-CSF in order to combat intercellular viral infection. It is one of the three experimentally described colony-stimulating factors. M-CSF binds to the colony stimulating factor 1 receptor. It may also be involved in development of the placenta.[5]
Structure
M-CSF is a cytokine, being a smaller protein involved in cell signaling. The active form of the protein is found extracellularly as a disulfide-linked homodimer, and is thought to be produced by proteolytic cleavage of membrane-bound precursors.[5]
Four transcript variants encoding three different isoforms (a proteoglycan, glycoprotein and cell surface protein)[6] have been found for this gene.[5]
Function
M-CSF (or CSF-1) is a hematopoietic growth factor that is involved in the proliferation, differentiation, and survival of
macrophages, and bone marrow progenitor cells.[7] M-CSF affects macrophages and monocytes in several ways, including stimulating increased phagocytic and chemotactic activity, and increased tumour cell cytotoxicity.[8]
The role of M-CSF is not only restricted to the monocyte/macrophage cell lineage. By interacting with its membrane receptor (CSF1R or M-CSF-R encoded by the c-fms proto-oncogene), M-CSF also modulates the proliferation of earlier hematopoietic progenitors and influence numerous physiological processes involved in immunology, metabolism, fertility and pregnancy.[9]
M-CSF released by
neoplastic growth.[11]
Clinical significance
Locally produced M-CSF in the vessel wall contributes to the development and progression of atherosclerosis.[12]
M-CSF has been described to play a role in renal pathology including acute kidney injury and chronic kidney failure.[13][14] The chronic activation of monocytes can lead to multiple metabolic, hematologic and immunologic abnormalities in patients with chronic kidney failure.[13] In the context of acute kidney injury, M-CSF has been implicated in promoting repair following injury,[15] but also been described in an opposing role, driving proliferation of a pro-inflammatory macrophage phenotype.[16]
As a drug target
CSF1R inhibitors
.
Interactions
Macrophage colony-stimulating factor has been shown to
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000184371 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000014599 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b c "Entrez Gene: CSF1 colony stimulating factor 1 (macrophage)".
- PMID 16951369.
- S2CID 20846803.
- PMID 8357512.
- PMID 9262961.
- PMID 29844945.
- S2CID 30541196.
- PMID 9637704.
- ^ PMID 8872977.
- S2CID 38517528.
- PMID 23143303.
- PMID 24048378.
- ^ Interest Builds in CSF1R for Targeting Tumor Microenvironment
- PMID 1334406.
Further reading
- Rajavashisth T, Qiao JH, Tripathi S, Tripathi J, Mishra N, Hua M, Wang XP, Loussararian A, Clinton S, Libby P, Lusis A (June 1998). "Heterozygous osteopetrotic (op) mutation reduces atherosclerosis in LDL receptor- deficient mice". The Journal of Clinical Investigation. 101 (12): 2702–10. PMID 9637704.
- Stanley ER, Berg KL, Einstein DB, Lee PS, Yeung YG (1995). "The biology and action of colony stimulating factor-1". Stem Cells. 12 (Suppl 1): 15–24, discussion 25. PMID 7696959.
- Alterman RL, Stanley ER (1994). "Colony stimulating factor-1 expression in human glioma". Molecular and Chemical Neuropathology. 21 (2–3): 177–88. S2CID 12846642.
- Stanley ER, Berg KL, Einstein DB, Lee PS, Pixley FJ, Wang Y, Yeung YG (January 1997). "Biology and action of colony--stimulating factor-1". Molecular Reproduction and Development. 46 (1): 4–10. S2CID 20846803.
- Sweet MJ, Hume DA (2004). "CSF-1 as a regulator of macrophage activation and immune responses". Archivum Immunologiae et Therapiae Experimentalis. 51 (3): 169–77. PMID 12894871.
- Mroczko B, Szmitkowski M (2005). "Hematopoietic cytokines as tumor markers". Clinical Chemistry and Laboratory Medicine. 42 (12): 1347–54. S2CID 11414705.
- Pandit J, Bohm A, Jancarik J, Halenbeck R, Koths K, Kim SH (November 1992). "Three-dimensional structure of dimeric human recombinant macrophage colony-stimulating factor". Science. 258 (5086): 1358–62. PMID 1455231.
- Suzu S, Ohtsuki T, Yanai N, Takatsu Z, Kawashima T, Takaku F, Nagata N, Motoyoshi K (March 1992). "Identification of a high molecular weight macrophage colony-stimulating factor as a glycosaminoglycan-containing species". The Journal of Biological Chemistry. 267 (7): 4345–8. PMID 1531650.
- Saltman DL, Dolganov GM, Hinton LM, Lovett M (February 1992). "Reassignment of the human macrophage colony stimulating factor gene to chromosome 1p13-21". Biochemical and Biophysical Research Communications. 182 (3): 1139–43. PMID 1540160.
- Praloran V, Chevalier S, Gascan H (May 1992). "Macrophage colony-stimulating factor is produced by activated T lymphocytes in vitro and is detected in vivo in T cells from reactive lymph nodes". Blood. 79 (9): 2500–1. PMID 1571567.
- Price LK, Choi HU, Rosenberg L, Stanley ER (February 1992). "The predominant form of secreted colony stimulating factor-1 is a proteoglycan". The Journal of Biological Chemistry. 267 (4): 2190–9. PMID 1733926.
- Pampfer S, Tabibzadeh S, Chuan FC, Pollard JW (December 1991). "Expression of colony-stimulating factor-1 (CSF-1) messenger RNA in human endometrial glands during the menstrual cycle: molecular cloning of a novel transcript that predicts a cell surface form of CSF-1". Molecular Endocrinology. 5 (12): 1931–8. PMID 1791839.
- Stein J, Borzillo GV, Rettenmier CW (October 1990). "Direct stimulation of cells expressing receptors for macrophage colony-stimulating factor (CSF-1) by a plasma membrane-bound precursor of human CSF-1". Blood. 76 (7): 1308–14. PMID 2145044.
- Sherr CJ, Rettenmier CW, Sacca R, Roussel MF, Look AT, Stanley ER (July 1985). "The c-fms proto-oncogene product is related to the receptor for the mononuclear phagocyte growth factor, CSF-1". Cell. 41 (3): 665–76. S2CID 32037918.
- Cerretti DP, Wignall J, Anderson D, Tushinski RJ, Gallis BM, Stya M, Gillis S, Urdal DL, Cosman D (August 1988). "Human macrophage-colony stimulating factor: alternative RNA and protein processing from a single gene". Molecular Immunology. 25 (8): 761–70. PMID 2460758.
- Takahashi M, Hirato T, Takano M, Nishida T, Nagamura K, Kamogashira T, Nakai S, Hirai Y (June 1989). "Amino-terminal region of human macrophage colony-stimulating factor (M-CSF) is sufficient for its in vitro biological activity: molecular cloning and expression of carboxyl-terminal deletion mutants of human M-CSF". Biochemical and Biophysical Research Communications. 161 (2): 892–901. PMID 2660794.
- Kawasaki ES, Ladner MB, Wang AM, Van Arsdell J, Warren MK, Coyne MY, Schweickart VL, Lee MT, Wilson KJ, Boosman A (October 1985). "Molecular cloning of a complementary DNA encoding human macrophage-specific colony-stimulating factor (CSF-1)". Science. 230 (4723): 291–6. PMID 2996129.
- Rettenmier CW, Roussel MF, Ashmun RA, Ralph P, Price K, Sherr CJ (July 1987). "Synthesis of membrane-bound colony-stimulating factor 1 (CSF-1) and downmodulation of CSF-1 receptors in NIH 3T3 cells transformed by cotransfection of the human CSF-1 and c-fms (CSF-1 receptor) genes". Molecular and Cellular Biology. 7 (7): 2378–87. PMID 3039346.
- Takahashi M, Hong YM, Yasuda S, Takano M, Kawai K, Nakai S, Hirai Y (May 1988). "Macrophage colony-stimulating factor is produced by human T lymphoblastoid cell line, CEM-ON: identification by amino-terminal amino acid sequence analysis". Biochemical and Biophysical Research Communications. 152 (3): 1401–9. PMID 3259875.
- Rettenmier CW, Roussel MF (November 1988). "Differential processing of colony-stimulating factor 1 precursors encoded by two human cDNAs". Molecular and Cellular Biology. 8 (11): 5026–34. PMID 3264877.
- Wong GG, Temple PA, Leary AC, Witek-Giannotti JS, Yang YC, Ciarletta AB, Chung M, Murtha P, Kriz R, Kaufman RJ (March 1987). "Human CSF-1: molecular cloning and expression of 4-kb cDNA encoding the human urinary protein". Science. 235 (4795): 1504–8. PMID 3493529.
External links
- Macrophage+Colony-Stimulating+Factor at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- Overview of all the structural information available in the PDB for UniProt: P09603 (Macrophage colony-stimulating factor 1) at the PDBe-KB.
