Mady Hornig

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Mady Hornig
Born1957 (age 66–67)
Mailman School of Public Health
WebsiteWebsite

Mady Hornig (born 1957) is an American

Beijing University in Beijing, China
.

Hornig has been described as an "anti-mercury activist".

obsessive compulsive disorders, and mood disorders
.

Education

Hornig received a bachelor's degree in 1978 from

Philadelphia. Between 1988 and 1992, Hornig served her residency in psychiatry at the University of Vermont. Under a National Research Service Award from the National Institutes of Mental Health, she completed a postdoctoral fellowship in neuropsychopharmacology on the Depression Research Unit of the University of Pennsylvania from 1992 to 1994.[4]

Career

In the 1990s, Hornig investigated the potential link between the Borna virus and depression in humans.[5]

Hornig has been described as being part of an "inner circle of anti-mercury activists" whose work has been funded in part by the anti-mercury campaigning group SafeMinds.[3]

In 2008, she published a study concluding that there was no association between presence of measles vaccine virus in the gut of children and whether these children had autism, nor was there an association between MMR exposure and autism.[6][7][8]

In 2011, she co-authored another study concluding that autistic children have altered expression of genes involved in digestion.[9] Regarding this study, Hornig said that its results "are consistent with other research suggesting that autism may be a system-wide disorder, and provide insight into why changes in diet or the use of antibiotics may help alleviate symptoms in some children."[10]

In 2015, Hornig co-authored a study that found that

chronic fatigue syndrome (CFS) in the early stages of the disease had higher levels of cytokines than people without CFS.[11][12]

Animal models

In the 1990s, Hornig helped to develop an infection-based model of neurodevelopmental disorders, such as

autism and depression, based on neonatal rat infection with Borna disease virus.[5][13]

In 2004, Hornig published a controversial paper concluding that, in a highly inbred strain of mice which is unusually susceptible to

thimerosal resulted in the development of autism-like symptoms; specifically, "growth delay; reduced locomotion; exaggerated response to novelty; and densely packed, hyperchromic hippocampal neurons with altered glutamate receptors and transporters."[14][15] In addition, in an interview with the Los Angeles Times, Hornig contended that thimerosal may be linked to the recent increases in the incidence of autism.[16] However, Paul Offit has accused Hornig of overstating her findings, arguing that her study was "a far cry from proving that thimerosal caused autism in children,"[17] and Steven Goodman, a member of the IOM panel that rejected a thimerosal-autism link in 2004, shortly before Hornig's study was published, has claimed that this study "in no way substitutes for actual human evidence."[18] Additionally, researchers from the University of California, Davis were unable to reproduce Hornig's results despite using the same strain of mice and ten times the amount of mercury used in Hornig's study.[19]

In 2006, Dan Olmsted reported that Hornig was working on a treatment program in which she would administer

gold salts to these genetically susceptible mice in an attempt to improve their behavior.[20]

In 2009, Hornig published another study using mice to examine the mechanism by which

OCD and tics, in line with the PANDAS hypothesis.[21][22] Hornig stated that her findings "illustrate that antibodies alone are sufficient to trigger this behavioral syndrome."[23]

Personal life

Hornig is a native of Brooklyn. She married Jim Hornig-Rohan in 1979. They met at the Cancer Institute of Harvard Medical School, when both were doing research in immunology. They have a child, Russell, who was born in July 1985.[24]

Select publications

  • Steven Locke, Mady Hornig-Rohan, Mind and Immunity: Behavioral Immunology, 1983,
    ISBN 0-275-91400-3
  • Jay D. Amsterdam, Mady Hornig, Andrew A. Nierenberg (editors), Treatment-Resistant Mood Disorders, 2001,
    ISBN 0-521-59341-7
  • Hornig M., Chian D., Lipkin W.I., 'Neurotoxic effects of postnatal thimerosal are mouse strain dependent', Molecular Psychiatry (September, 2004)
  • Cox-Foster, D. L.; Conlan, S.; Holmes, E. C.; Palacios, G.; Evans, J. D.; Moran, N. A.; Quan, P. -L.; Briese, T.; Hornig, M.; Geiser, D. M.; Martinson, V.; Vanengelsdorp, D.; Kalkstein, A. L.; Drysdale, A.; Hui, J.; Zhai, J.; Cui, L.; Hutchison, S. K.; Simons, J. F.; Egholm, M.; Pettis, J. S.; Lipkin, W. I. (2007). "A Metagenomic Survey of Microbes in Honey Bee Colony Collapse Disorder". Science. 318 (5848): 283–287.
    S2CID 14013425
    .
  • Mady Hornig, Thomas Briese, Timothy Buie, Margaret L. Bauman, Gregory Lauwers, Ulrike Siemetzki, Kimberly Hummel, Paul A. Rota, William J. Bellini, John J. O'Leary, Orla Sheils, Errol Alden, Larry Pickering, W. Ian Lipkin - 'Lack of Association between Measles Virus Vaccine and Autism with Enteropathy: A Case-Control Study',
    PLoS ONE
     (September, 2008)

References

  1. ^ Hornig-Rohan, Mady (2001). Treatment-Resistant Mood Disorders. Cambridge University Press. pp. iv.
  2. ^ "Mady Hornig, Columbia University". December 2022.
  3. ^
    S2CID 1798838
    .
  4. ^ "Mady Hornig, M.A., M.D." harvard.edu.
  5. ^ a b Flam, Faye (23 July 1996). "Is Depression Viral?". Chicago Tribune. Retrieved 14 February 2015.
  6. PMID 18769550
    .
  7. ^ McKenzie, John (3 September 2008). "Study Finds Vaccine Not Linked to Autism". ABC News. Retrieved 10 October 2013.
  8. Wall Street Journal
    . Retrieved 12 October 2013.
  9. PMID 21949732
    .
  10. ^ "Children With Autism and Gastrointestinal Symptoms Have Altered Digestive Genes". ScienceDaily. 18 September 2011. Retrieved 12 October 2013.
  11. PMID 26079000
    .
  12. ^ "Distinct stages to chronic fatigue syndrome identified". BBC News. 28 February 2015. Retrieved 13 September 2015.
  13. PMID 10518583
    .
  14. PMID 15184908
    .
  15. Eurekalert!
    . Retrieved 10 October 2013.
  16. ^ Maugh, Thomas H., II (9 June 2004). "Study Finds Genetic Link Between Autism, Vaccines". Los Angeles Times. Retrieved 10 October 2013.{{cite web}}: CS1 maint: multiple names: authors list (link)
  17. ISBN 978-0-231-14636-4
    .
  18. ^ Barclay, Laurie (11 June 2004). "IOM Report, Mouse Study Continue Debate on Vaccine-Autism Link". Medscape. Retrieved 10 October 2013.
  19. PMID 18394707
    .
  20. ^ "The Age of Autism: New test of gold salts". UPI.
  21. PMID 19668249
    .
  22. doi:10.1038/scientificamericanmind0110-17a
    . Retrieved 25 December 2013.
  23. ^ "Antibodies to strep throat bacteria linked to obsessive compulsive disorder in mice - (e) Science News". esciencenews.com.
  24. Philly.com
    . Retrieved 10 October 2013.

External links

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