Malassezia

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Malassezia
Malassezia furfur in skin scale from a patient with tinea versicolor
Scientific classification Edit this classification
Domain: Eukaryota
Kingdom: Fungi
Division: Basidiomycota
Subdivision: Ustilaginomycotina
Class: Malasseziomycetes
Denchev & T.Denchev (2014)
Order: Malasseziales
R.T.Moore
(1980)
Family: Malasseziaceae
Denchev & R.T.Moore (2009)
Genus: Malassezia
Baill. (1889)[1]
Type species
C.P.Robin
) Baill. (1889)
Synonyms[2]

Malassezia (formerly known as Pityrosporum) is a

fungi. It is the sole genus in family Malasseziaceae, which is the only family in order Malasseziales, itself the single member of class Malasseziomycetes.[3] Malassezia species are naturally found on the skin surfaces of many animals, including humans. In occasional opportunistic infections, some species can cause hypopigmentation or hyperpigmentation on the trunk and other locations in humans. Allergy tests for these fungi are available. It is believed French revolutionary Jean-Paul Marat suffered from a fungal infection from Malassezia restricta, which lead to his frequent bathing in a medicinal substance.[4]

Systematics

pityrosporum folliculitis and electron micrograph of his skin, showing Malassezia spores.[5]

Due to progressive changes in their nomenclature, some confusion exists about the naming and classification of Malassezia

growth media and grow very slowly in laboratory culture.[6]

Malassezia was originally identified by the French scientist Louis-Charles Malassez in the late nineteenth century;[7] he associated it with the condition seborrhoeic dermatitis.[8] Raymond Sabouraud identified a dandruff-causing organism in 1904 and called it Pityrosporum Malassezii,[9] honoring Malassez, but at the species level as opposed to the genus level. When it was determined that the organisms were the same, the term "Malassezia" was judged to possess priority.[10]

In the mid-twentieth century, it was reclassified into two species:

  • Pityrosporum (Malassezia) ovale, which is lipid-dependent and found only on humans. P. ovale was later divided into two species, P. ovale and P. orbiculare, but current sources consider these terms to refer to a single species of fungus, with M. furfur the preferred name.[11]
  • Pityrosporum (Malassezia) pachydermatis, which is lipophilic but not lipid-dependent. It is found on the skin of most animals.

In the mid-1990s, scientists at the Pasteur Institute in Paris, France, discovered additional species.[12]

Malassezia is the sole genus in the family Malasseziaceae, which was validated by Cvetomir Denchev and Royall T. Moore in 2009.[13] The order Malasseziales had been previously proposed by Moore in 1980,[14] and later emended by Begerow and colleagues in 2000. At this time the order was classified as a member of unknown class placement in the subdivision Ustilaginomycotina.[15] In 2014, Cvetomir and Teodor Denchev circumscribed the class Malasseziomycetes to contain the group.[16]

Description

Malassezia demonstrates a rapid growth rate, typically maturing within 5 days when incubated at temperatures ranging from 30–35 °C (86–95 °F). Growth is less optimal at 25 °C (77 °F), and certain species struggle at 37 °C (99 °F). These organisms can proliferate on media infused with

long-chain fatty acids, with M. pachydermatis being an exception. The most conventional cultivation method involves overlaying solid media with a layer of olive oil. However, for nurturing some clinically relevant species, such as the challenging-to-cultivate M. restricta, more intricate culture media may be required. For the most efficient recovery of Malassezia, it has been recommended to collect blood through a lipid infusion catheter and subsequently use lysis-centrifugation—a recommendation backed by multiple comparative studies.[17]

The yeast-like cells of Malassezia, measuring between 1.5–4.5 

light microscopes. A defining characteristic of cells from this genus is their morphology: one end is round, while the other has a distinctly blunt termination. This latter end is where singular, broad-based bud-like structures emerge, although in certain species, these structures might be narrower. To effectively visualise the organism's shape, a staining technique involving safranin is recommended, followed by observation under oil immersion. Furthermore, Calcofluor-white staining provides an enhanced clarity of the cell wall and its unique contour. While Malassezia typically lacks hyphal elements, rudimentary forms can sporadically be present.[17]

Species

Species Fungorum accepts 22 species of Malassezia.[18] The following list gives the name of the fungus, the taxonomic authority (those who first described the fungus, or who transferred it into Malassezia from another genus; standardized author abbreviations
are used), and the name of the organism from which the fungus was isolated, if not human.

Role in human diseases

Dermatitis and dandruff

Identification of Malassezia on skin has been aided by the application of molecular or DNA-based techniques. These investigations show that the Malassezia species causing most skin disease in humans, including the most common cause of dandruff and seborrhoeic dermatitis, is M. globosa (though M. restricta is also involved).[25] The skin rash of tinea versicolor (pityriasis versicolor) is also due to infection by this fungus.

As the fungus requires fat to grow,[12] it is most common in areas with many sebaceous glands: on the scalp,[37] face, and upper part of the body. When the fungus grows too rapidly, the natural renewal of cells is disturbed, and dandruff appears with itching (a similar process may also occur with other fungi or bacteria).

A project in 2007 sequenced the genome of dandruff-causing Malassezia globosa and found it to have 4,285 genes.

phospholipases
, to break down the oils on the scalp. Any of these 11 proteins would be a suitable target for dandruff medications.

The number of specimens of M. globosa on a human head can be up to ten million.[37]

M. globosa has been predicted to have the ability to reproduce sexually,[40] but this has not been observed.

Research

Malassezia is among the many

complement.[42][43]

The yeast M. restricta, normally found in the skin, is linked to disorders like Crohn's disease and inflammatory bowel disease when found in the gut, especially for those with the N12 CARD9 allele, which provokes a stronger inflammatory response to the yeast.[44]

References

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  4. ^ "Mystery of Jean-Paul Marat's bathing habit… - The Good Life France". thegoodlifefrance.com. 2021-06-14. Archived from the original on 2024-01-19. Retrieved 2024-01-19.
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  7. ^ Malassez, L. (1874). "Note sur le champignon du pityriasis simple" [Note on the fungus of simple pityriasis]. Archives of Physiology and Biochemistry (in French). 2: 451–464.
  8. PMID 30870616
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  9. ^ Sabouraud, R. (1904). Maladies du cuir chevelu: II. Les maladies desquamatives [Scalp conditions: II. Desquamative disorders] (in French). Paris: Masson et Cie. p. 646.
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  14. ^ Moore, R.T. (1980). "Taxonomic proposals for the classification of marine yeasts and other yeast-like fungi including the smuts". Botanica Marina. 23 (6): 361–373.
  15. doi:10.1017/s0953756299001161
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  16. ^ Denchev, C.M.; Denchev, T.T. (2014). "Nomenclatural novelties" (PDF). Index Fungorum. 145: 1. Archived (PDF) from the original on 2015-02-06. Retrieved 2021-12-06.
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  18. Catalog of Life. Archived
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  29. ^ Maecke, Margarita (1941). "Descripción de una nueva especie de Malassezia: Malassezia ochoterenai, agente causal de Pytiriasis (Tinea) vesicolor y posición sistemática del género Malassezia". Anales del Instituto de Biología (in Spanish). 12: 511–546.
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  37. ^ a b "Genetic code of dandruff cracked". BBC News. BBC. 2007-11-06. Archived from the original on 2008-12-22. Retrieved 2008-12-10.
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  39. ^ Spectrum Science Public Relations (21 November 2007). "Scientists Complete Genome Sequence Of Fungus Responsible For Dandruff, Skin Disorders". ScienceDaily. Archived from the original on 28 December 2007. Retrieved 5 February 2023.
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Further reading
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