Mapatumumab

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Mapatumumab
death receptor 4)
Clinical data
ATC code
  • none
Identifiers
CAS Number
ChemSpider
  • none
UNII
Chemical and physical data
FormulaC6748H10408N1800O2092S52
Molar mass151891.12 g·mol−1
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Mapatumumab (HGS-ETR1) is an experimental

TRAIL-R1, also known as DR4, which is expressed on the surface of many tumor cell types.[2]

Development history

This drug was discovered by

GlaxoSmithKline, as a result of the collaboration between the two companies in 1999 in exploitation of CAT's phage display technology. Early work by the two companies indicated that mapatumumab induced cell death in multiple tumor types both in vitro and in vivo.[3]

Clinical trials

A phase 1

non-Hodgkin’s lymphoma, according to HGS.[8]

Multiple myeloma

In 2008 HGS reported initial results of a randomised phase 2 trial of mapatumumab in combination with bortezomib in advanced multiple myeloma.[9] However, in 2010, mapatumumab failed in a midstage study. There was no difference in disease response or progression-free survival rates between patients receiving the drug for multiple myeloma and the control group.[10]

Non-small-cell lung cancer

"In August 2008, ... initial dosing of patients in a randomized Phase 2 trial of HGS-ETR1 (10 mg/kg or 30 mg/kg) in combination with paclitaxel and carboplatin as first-line therapy in patients with advanced non-small-cell lung cancer (NSCLC); initial data from the study are anticipated in 2009."[9]

Liver cancer

"In July 2008, HGS initiated dosing in ... a randomized Phase 2 trial of HGS-ETR1 in combination with Nexavar (sorafenib) in patients with advanced hepatocellular cancer, which accounts for 80-90% of all liver cancers."[9]

See also

References

  1. ^ Statement On A Nonproprietary Name Adopted By The Usan Council - Mapatumumab, American Medical Association.
  2. S2CID 71176481
    .
  3. PMID 15846298
    .
  4. ^ "Human Genome Sciences reports results of ongoing phase 1 clinical trials of HGS-ETR1 in patients with advanced cancers". Human Genome Sciences. September 29, 2004. Archived from the original on September 6, 2012. Retrieved August 7, 2009.
  5. ^ "Human Genome Sciences reports results of phase 2 clinical trial of HGS-ETR1 in patients with non-small-cell lung cancer". Human Genome Sciences. July 5, 2005. Archived from the original on May 15, 2008. Retrieved August 7, 2009.
  6. ^ "Human Genome Sciences reports results of phase 2 clinical trial of HGS-ETR1 in patients with advanced colorectal cancer". Human Genome Sciences. November 1, 2005. Archived from the original on May 16, 2008. Retrieved August 7, 2009.
  7. ^ "Human Genome Sciences reports interim results of phase 1B clinical trials of HGS-ETR1 in combination with chemotherapy in patients with advanced solid tumors". Human Genome Sciences. November 17, 2005. Archived from the original on May 15, 2008. Retrieved August 7, 2009.
  8. ^ "Human Genome Sciences reports results of phase 2 clinical trial of HGS-ETR1 in patients with advanced non-Hodgkin's lymphoma". Human Genome Sciences. December 13, 2005. Archived from the original on May 15, 2008. Retrieved August 7, 2009.
  9. ^ a b c "Human Genome Sciences reports initial results of randomized phase 2 clinical trial of HGS-ETR1 in combination with bortezomib in advanced multiple myeloma". Human Genome Sciences. September 2, 2008. Archived from the original on July 28, 2011. Retrieved August 7, 2009.
  10. ^ "Human Genome Sciences says cancer drug fails study". bloomberg.com. June 9, 2010. Archived from the original on October 24, 2012.
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