Marbofloxacin

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Marbofloxacin
Clinical data
Trade namesXeniQuin bolus & Injection (Opsonin Agrovet BD)
AHFS/Drugs.comInternational Drug Names
Routes of
administration		By mouth
ATCvet code
Legal status
Legal status
Identifiers
  • 9-fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyridol(3,2,1-ij)(4,2,1)benzoxadiazin-6 carboxylic acid
JSmol)
  • Fc4cc1c2N(/C=C(\C1=O)C(=O)O)N(COc2c4N3CCN(C)CC3)C
  • InChI=1S/C17H19FN4O4/c1-19-3-5-21(6-4-19)14-12(18)7-10-13-16(14)26-9-20(2)22(13)8-11(15(10)23)17(24)25/h7-8H,3-6,9H2,1-2H3,(H,24,25) checkY
  • Key:BPFYOAJNDMUVBL-UHFFFAOYSA-N checkY
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Marbofloxacin is a carboxylic acid derivative third generation

CAS number
115550-35-1).

Mechanism of action

Its mechanism of action is not thoroughly understood, but it is believed to be similar to the other

RNA synthesis respectively.[2][clarification needed
]

Activity

Marbofloxacin is a synthetic, broad spectrum

post-antibiotic effect for both gram– and + bacteria and is active in both stationary and growth phases of bacterial replication.[3]

It has good activity against many

cocci
, is effective against:

Application

Marbofloxacin can be used both orally and topically. It is particularly used for

urinary tract infections. For dogs, a dose ranges from 2.75 - 5.5 mg/kg once a day. The duration of treatment is usually at least five days, longer if there is a concurrent fungal or yeast infection.[4] Maximum duration of treatment is 30 days.[3]

Contraindications and side effects

Marbofloxacin should usually be avoided in young animals because of potential cartilage abnormalities. In rare occasion, it can cause

cramps, treatable with diazepam. Other adverse effects are usually limited to gastrointestinal tract (GI) distress (vomiting, anorexia, soft stools, diarrhoea) and decreased activity.[3]

References

  1. ^ Boothe, D.M. (2001) Antimicrobial drugs. In Small Animal ClinicalPharmacology and Therapeutics, pp. 150–173. W. B. Saunders Co., Philadelphia, PA.
  2. ^ Hunter RP, Koch DE, Coke RL, Carpenter JW, Isaza R. Identification and comparison of marbofloxacin metabolites from the plasma of ball pythons (Python regius) and blue and gold macaws (Ara ararauna). J Vet Pharmacol Ther. 2007 Jun;30(3):257-62.
  3. ^ a b c d Plumb DC (ed). Plumb's Veterinary Handbook, 7th ed. Ames, IA: Wiley-Blackwell Publishing, 2011.
  4. PMID 16238809. Archived from the original
    on 2013-01-05.
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