Marilyn Farquhar

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Marilyn Farquhar
Born(1928-07-11)July 11, 1928
George Palade

Marilyn Gist Farquhar (July 11, 1928 – November 23, 2019) was a pathologist and

E. B. Wilson Medal and the FASEB Excellence in Science Award. She[2] was married to Nobel Laureate George Emil Palade from 1970 to his death in 2008.[3] Her research focuses on control of intracellular membrane traffic and the molecular pathogenesis of auto immune kidney diseases. She has yielded a number of discoveries in basic biomedical research including: mechanisms of kidney disease, organization of functions that attach cells to one another, and mechanisms of secretions.[4]

Early life

Marilyn Gist Farquhar was born on 11 July 1928 and was raised in the Central Valley farming community of Tulare, California.[5] Her father was from a pioneer family and worked as an insurance agent and farmer, who spent his free time writing novels. Her mother was also from a pioneer family and had begun college, but had to return home before completing her degree.[6] Farquhar attributes her desire to pursue a career in medicine and biology to her mother's friend, Frances Zumwalt, who was a pediatrician.[6]

Education and career

Farquhar received her undergraduate degree in

podocytes
.

After leaving Rockefeller in 1962, she established her own laboratory at the

lysosomes.[6]

In 1970, she divorced her first husband and married

George Palade and James D. Jamieson.[7] While at Yale, Farquhar's research focused on secretory granule membranes that merge with cell membranes during exocytosis.[6]
She also identified several glomerular components that play a role in glomerular functions.

In 1990, Farquhar and Palade returned home to California to help build and strengthen cell and molecular biology at the

growth factors and determines the fate of growth factor receptors.[6]
Throughout Farquhar's lifetime, she has witnessed and helped guide the evolution of the field of cellular biology.

Research

Throughout Farquhar's career, her lab maintained two research interests – control of intracellular membrane traffic and the molecular

cell secretion, intracellular membrane traffic, and glomerular permeability and pathology.[5] Farquhar's research yielded a number of discoveries in basic biomedical research, including mechanisms of kidney disease, organization of functions that attach cells to one another, and the mechanisms of secretions.[4]

The Farquhar Lab was in the Department of Cellular and Molecular Medicine at the

podocytes. The long-term goal for these three projects is to define the molecular mechanisms of glomerular filtration and protein absorption under normal and pathogenic conditions.[8]

Her research was funded by grants from the National Cancer Institute, the Susan Komen Foundation for Breast Cancer Research, and the National Institute of Diabetes, Digestive and Kidney Diseases.[10]

Awards

  • 1981 - President of
    American Society of Cell Biology
  • 1987 - E.B. Wilson Medal of the American Society of Cell Biology
  • 1988 - Homer Smith Medal of the American Society of Nephrology
  • 1987 - Distinguished Scientist Medal of the Electron Microscopy Society of America
  • 1988 -
    National Institutes of Health Merit Award
  • 1991 - Elected to the American Academy of Arts and Sciences[11]
  • 1997 - Chancellor's award for Excellence in Research at UCSD
  • 1999 - Gomori Award from The Histochemical Society
  • 2001 - Rous-Whipple Award of the American Society for Investigative Pathology
  • 2006 - Federation of American Societies of Experimental Biology Award for Excellence in Science
  • 2017 - Revelle Medal

Selected publications

  1. Farquhar, M.G. 2012. A Man for All Seasons: Reflections on the Life and Legacy of George Palade. Annu Rev Cell Dev Biol. Volume 28. In Press.
  2. Ghosh, P, Garcia-Marcos, M., and M.G. Farquhar. 2011. GIV/Girdin is a rheostat that fine-tunes growth factor signals during tumor progression. Cell Adhes. Migr. 5(3):237-48.
  3. García-Marcos, M., Ghosh, P., and M.G. Farquhar. 2009. GIV is a non-receptor GEF factor for Galphai with a unique motif that regulates Akt signaling. PNAS. 106(9):3178-83.
  4. Head BP, Patel HH, Roth DM, Murray F, Swaney JS, Niesman IR, Farquhar MG, Insel PA. Microtubules and actin microfilaments regulate lipid raft/caveolae localization of adenylyl cyclase signaling components. J Biol Chem. 2006 Jul 3;
    PMID 16818493
  5. Farquhar, M. G. 2006. The glomerular basement membrane: not gone, just forgotten. J. Clin. Invest. 116:2090-2093.
  6. Zhang YW, Luo WJ, Wang H, Lin P, Vetrivel KS, Liao F, Li F, Wong PC, Farquhar MG, Thinakaran G, Xu H. 2005. Nicastrin is critical for stability and trafficking but not association of other presenilin/g-secretase components. J. Biol. Chem. 280:17020-17026.
  7. Lehtonen, S., Ryan, J. J, Kudlicka, K., Iino, N., Zhou, H., and M. G. Farquhar. 2005. Cell junction-associated proteins IQGAP1, MAGI-2, CASK, spectrins, and alpha-actinin are components of the nephrin multiprotein complex. Proc. Natl. Acad. Sci. 102:9814-19.
  8. Head, B. P., Patel, H. H., Roth, D. M., Niesman, I. R., Farquhar, M. G. and P. A. Insel. 2005. G-protein-coupled receptor signaling components localize in both sarcolemmal and intracellular caveolin-3-associated microdomains in adult cardiac myocytes. J. Biol. Chem. 280: 31036-44.
  9. Rader, K., Boyer, A. D., Farquhar, M. G., and K. C. Arden. 2000. Assignment of ankyrin repeat, family A (RFXANK-like) 2 (ANKRA2) to human chromosome 5q12-q13 by radiation hybrid mapping and somatic cell hybrid PCR. Cytogenet. Cell Genet. 89:164-165.
  10. Zheng, B., Chen, D. and M.G. Farquhar. 2000. MIR16, a putative membrane glycerophosphodiester phosphodiesterase, interacts with RGS16. Proc. Natl. Acad. Sci. 97:3999-4004.
  11. Farquhar, M.G. 1996. Molecular analysis of the pathologic autoimmune antigens of Heymann nephritis. Am. J. Path. 148:1331-1337.
  12. Kerjaschki, D., R. Ullrich, M. Exner, R.A. Orlando and M.G. Farquhar 1996. Induction of passive Heymann nephritis with antibodies specific for synthetic peptides. J. Exp. Med. 183:2007-2016.
  13. Jin, M.J., Saucan, L., Farquhar, M.G., and Palade, G.E. 1996. Rab1a and multiple other rab proteins are associated with the transcytotic pathway in rat liver. J. Biol. Chem. 271:30105-30113.

References

  1. ^ "University of California, San Diego: Faculty Profile". Archived from the original on 2010-12-21. Retrieved 2009-10-16.
  2. ^ "ASIP". Archived from the original on 2007-08-22. Retrieved 2012-10-15.
  3. ^ "George E. Palade - Biographical". nobelprize.org.
  4. ^ a b c d e f g Wayne, Tiffany. American Women of Science Since 1990. Greenwood Publishing Group, 2011, p. 384-386
  5. ^ a b c d e f g Oakes, Elizabeth. Encyclopedia of World Scientists. Facts on File, 2007, p.224
  6. ^ a b c d e f g Sedwick, Caitlin. “Marilyn Farquhar: From the beginning”, “The Rockefeller University Press”, 25 Nov. 2013
  7. ^ a b c d e “Marilyn Gist Farquhar” Archived 2015-09-23 at the Wayback Machine, “The American Society for Cell Biology”, 1995
  8. ^ a b Farquhar, Marilyn. “Research” Archived 2015-08-04 at the Wayback Machine
  9. ^ a b Farquhar, Marilyn. “Marilyn G. Farquhar, Ph.D.” UC San Diego School of Medicine.
  10. ^ Farquhar, Marilyn. “Biography: Marilyn G. Farquhar, Ph.D.” Archived 2013-05-27 at the Wayback Machine
  11. ^ "Marilyn G. Farquhar". American Academy of Arts & Sciences. Retrieved 3 May 2019.

Further reading

  • Shearer, B. F.; Shearer, B. S., eds. (1996). Notable women in the life sciences : a biographical dictionary. Westport, Conn.: Greenwood Press. .

External links