Mario Capecchi

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Mario R. Capecchi
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Mario Capecchi
James D. Watson
Websitecapecchi.genetics.utah.edu

Mario Ramberg Capecchi (born 6 October 1937) is an Italian-born molecular

Human Genetics and Biology at the University of Utah School of Medicine.[8][9][10][11][12]

Life

Mario Capecchi was born in

Fascist group.[14] Prior to her arrest[15] she had made contingency plans by selling her belongings and giving the proceeds to a nearby peasant family to care for her child. However, it was not long before Mario ended up on the streets of Bolzano.[16][17] In July 1942, a few months before his fifth birthday, Italian records suggest he was reunited with his father in Reggio Emilia, which Mario did confirm but stated that he stayed with his father for only for a few brief periods [18]
and that he mostly lived on the streets until he was placed in an orphanage towards the end of the war.

Mario almost died of malnutrition. His mother survived the war in Germany (part of the reason the details of his early life are unclear is that she would never talk about her experiences), and when it ended she began a year-long search for him. She finally found him on his ninth birthday in a hospital bed in Reggio Emilia ill with a fever and subsisting on a daily bowl of

Bryn Gweled,[19] which had been co-founded by his uncle. (Capecchi's other maternal uncle, Walter Ramberg, was also a prominent American physicist[20]). He graduated from George School, a Quaker boarding school in Bucks County, Pennsylvania, in 1956.[15]

Capecchi received his

PhD in biophysics in 1967[23] from Harvard University
, with his doctoral thesis completed under the tutelage of Watson.

Capecchi was a Junior Fellow of the Society of Fellows at Harvard University from 1967 to 1969. In 1969 he became an assistant professor in the Department of

Italy-USA Foundation
.

After the Nobel committee publicly announced that Capecchi was awarded the Nobel prize, an Austrian woman named Marlene Bonelli claimed that Capecchi was her long-lost half-brother.[26] In May 2008, Capecchi met with Bonelli, then 69, in northern Italy, and confirmed that she was his sister.[27]

Knockout mice

Capecchi was awarded the Nobel prize for creating a knockout mouse. This is a mouse, created by genetic engineering and in vitro fertilization, in which a particular gene has been turned off.[28] For this work, Capecchi was awarded the 2007 Nobel prize for medicine or physiology, along with Martin Evans and Oliver Smithies, who also contributed.

Capecchi has also pursued a systematic analysis of the mouse

multicellular animals
. They determine the placement of cellular development in the proper order along the axis of the body from head to toe.

Honours

References

  1. S2CID 31781543
    .
  2. S2CID 31961262
    .
  3. S2CID 2997260
    .
  4. S2CID 2189404
    .
  5. S2CID 972118
    .
  6. S2CID 30570106
    .
  7. ^ a b "The Nobel Prize in Physiology or Medicine 2007". Nobelprize.org. Retrieved 2007-10-08.
  8. Microsoft Academic
  9. PMID 19093023
    .
  10. PMID 18154719
    .
  11. S2CID 31781543
    .
  12. S2CID 4347862
    .
  13. Deseret Morning News
    .
  14. Salt Lake Tribune
    . Retrieved 2007-10-08.
  15. ^ a b Susan Sample (2007). "Scientist Profile: Mario Capecchi". University of Utah. Archived from the original on 2007-10-11.
  16. ^ "The Nobel Prize in Physiology or Medicine 2007". NobelPrize.org. Retrieved 20 February 2022.
  17. PMID 18232538
    .
  18. ^ "Nobelist's tales of wartime have inconsistencies". Deseret News. Associated Press. 6 November 2007. Retrieved 20 February 2022.
  19. ^ American Philosophical Society. "Edward G. Ramberg Papers". American Philosophical Society.
  20. ^ "Obituaries". The Washington Post. Retrieved 2022-06-11.
  21. ^ Andrew Gumbel (2007-10-09). "Mario Capecchi: The man who changed our world". Belfast Telegraph.
  22. ^ Arkajit Dey (2007-10-16). "Two Nobel Prize Winners MIT-Affiliated". The Tech.
  23. ProQuest 302261581
    .
  24. ^ "Distinguished Lecture Series". Duke University. Archived from the original on 2007-09-08.
  25. ^ "MBG Annual Racker Lecture". Cornell University.
  26. ^ Peter Popham (2007-10-18). "Reunion beckons for Nobel winner and his long lost step-sister". Belfast Telegraph.
  27. ^ "'Looking at the pictures, it was obviously my sister,' Capecchi said, noting her resemblance to their mother.""Nobel Winner Reunited With Sister Lost in WWII". ABC News. Associated Press. 2008-06-06.
  28. ^ University of Utah, Transgenic Mice
  29. ^ "2001 Albert Lasker Award for Basic Medical Research". Lasker Foundation. Archived from the original on 2007-09-30. Retrieved 2007-10-01.
  30. ^ "The President's National Medal of Science: Recipient Details | NSF - National Science Foundation". www.nsf.gov.
  31. ^ "Past Winners". www.brandeis.edu.
  32. ^ "UCSF Medal". Office of the Chancellor. Retrieved 1 July 2020.
  33. S2CID 32962450
    .

External links
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