Mast cell stabilizer
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Cromolyn
Mast cell stabilizers are medications used to prevent or treat certain allergic disorders. They block mast cell degranulation, stabilizing the cell and thereby preventing the release of histamine[1] and related mediators. One suspected pharmacodynamic mechanism is the blocking of IgE-regulated calcium channels. Without intracellular calcium, the histamine vesicles cannot fuse to the cell membrane and degranulate.
As inhalers they are used to treat
hay fever (allergic rhinitis) and as eye drops for allergic conjunctivitis.[2] Finally, in oral form, they are used to treat the rare condition of mastocytosis
.
Examples
Mast cell stabilizer medications include:
- Cromoglicic acid[1][3][4][5] (Cromolyn/cromoglycate)
- Lodoxamide[1][3]
- Nedocromil[1][3][4]
References
- ^ a b c d "Allergy medications: Know your options". Mayoclinic.com. 2022-03-05. Retrieved 2023-04-02.
- PMID 26028608.
- ^ a b c d e f g h "Mast Cell Stabilizers: Uses, most common brand names, and safety information". nicerx.com. Retrieved 2023-04-02.
- ^ a b "Mast cell stabilizers". drugs.com. Retrieved 2023-04-02.
- PMID 23441583.
- S2CID 4643742.