Nanomedicine
This article needs more primary sources. (August 2014) |
Part of a series of articles on the |
Impact of nanotechnology |
---|
Health and safety |
Environmental |
Other topics |
Nanomedicine is the medical application of
Functionalities can be added to nanomaterials by interfacing them with biological molecules or structures. The size of nanomaterials is similar to that of most biological molecules and structures; therefore, nanomaterials can be useful for both in vivo and in vitro biomedical research and applications. Thus far, the integration of nanomaterials with biology has led to the development of diagnostic devices, contrast agents, analytical tools, physical therapy applications, and drug delivery vehicles.
Nanomedicine seeks to deliver a valuable set of research tools and clinically useful devices in the near future.[4][5] The National Nanotechnology Initiative expects new commercial applications in the pharmaceutical industry that may include advanced drug delivery systems, new therapies, and in vivo imaging.[6] Nanomedicine research is receiving funding from the US National Institutes of Health Common Fund program, supporting four nanomedicine development centers.[7]
Nanomedicine sales reached $16 billion in 2015, with a minimum of $3.8 billion in nanotechnology R&D being invested every year. Global funding for emerging nanotechnology increased by 45% per year in recent years, with product sales exceeding $1 trillion in 2013.[8] As the nanomedicine industry continues to grow, it is expected to have a significant impact on the economy.
Drug delivery
Drug delivery systems, lipid-
Nanoparticles are under research for their potential to decrease
Systems under research
Advances in lipid nanotechnology were instrumental in engineering medical nanodevices and novel drug delivery systems, as well as in developing sensing applications.
Applications
Some nanotechnology-based drugs that are commercially available or in human clinical trials include:
- is the nanoparticle albumin bound paclitaxel.
- Doxil was originally approved by the FDA for the use on HIV-related Kaposi's sarcoma. It is now being used to also treat ovarian cancer and multiple myeloma. The drug is encased in liposomes, which helps to extend the life of the drug that is being distributed. Liposomes are self-assembling, spherical, closed colloidal structures that are composed of lipid bilayers that surround an aqueous space. The liposomes also help to increase the functionality and it helps to decrease the damage that the drug does to the heart muscles specifically.[38]
- Onivyde, liposome encapsulated irinotecan to treat metastatic pancreatic cancer, was approved by FDA in October 2015.[39]
- Rapamune is a nanocrystal-based drug that was approved by the FDA in 2000 to prevent organ rejection after transplantation. The nanocrystal components allow for increased drug solubility and dissolution rate, leading to improved absorption and high bioavailability.[40]
- Cabenuva is approved by FDA as cabotegravir extended-release injectable nano-suspension, plus rilpivirine extended-release injectable nano-suspension. It is indicated as a complete regimen for the treatment of HIV-1 infection in adults to replace the current antiretroviral regimen in those who are virologically suppressed (HIV-1 RNA less than 50 copies per mL) on a stable antiretroviral regimen with no history of treatment failure and with no known or suspected resistance to either cabotegravir or rilpivirine. This is the first FDA-approved injectable, complete regimen for HIV-1 infected adults that is administered once a month.
Imaging
In vivo imaging is another area where tools and devices are being developed.
The small size of nanoparticles endows them with properties that can be very useful in
Tracking movement can help determine how well drugs are being distributed or how substances are metabolized. It is difficult to track a small group of cells throughout the body, so scientists used to dye the cells. These dyes needed to be excited by light of a certain wavelength in order for them to light up. While different color dyes absorb different frequencies of light, there was a need for as many light sources as cells. A way around this problem is with luminescent tags. These tags are
Sensing
Nanotechnology-on-a-chip is one more dimension of lab-on-a-chip technology. Magnetic nanoparticles, bound to a suitable antibody, are used to label specific molecules, structures or microorganisms. In particular silica nanoparticles are inert from the photophysical point of view and might accumulate a large number of dye(s) within the nanoparticle shell.[45] Gold nanoparticles tagged with short segments of DNA can be used for detection of genetic sequence in a sample. Multicolor optical coding for biological assays has been achieved by embedding different-sized quantum dots into polymeric microbeads. Nanopore technology for analysis of nucleic acids converts strings of nucleotides directly into electronic signatures.[citation needed]
Sensor test chips containing thousands of nanowires, able to detect proteins and other biomarkers left behind by cancer cells, could enable the detection and diagnosis of cancer in the early stages from a few drops of a patient's blood.[46] Nanotechnology is helping to advance the use of arthroscopes, which are pencil-sized devices that are used in surgeries with lights and cameras so surgeons can do the surgeries with smaller incisions. The smaller the incisions the faster the healing time which is better for the patients. It is also helping to find a way to make an arthroscope smaller than a strand of hair.[47]
Research on nanoelectronics-based cancer diagnostics could lead to tests that can be done in pharmacies. The results promise to be highly accurate and the product promises to be inexpensive. They could take a very small amount of blood and detect cancer anywhere in the body in about five minutes, with a sensitivity that is a thousand times better a conventional laboratory test. These devices are built with nanowires to detect cancer proteins; each nanowire detector is primed to be sensitive to a different cancer marker.[32] The biggest advantage of the nanowire detectors is that they could test for anywhere from ten to one hundred similar medical conditions without adding cost to the testing device.[48] Nanotechnology has also helped to personalize oncology for the detection, diagnosis, and treatment of cancer. It is now able to be tailored to each individual's tumor for better performance. They have found ways that they will be able to target a specific part of the body that is being affected by cancer.[49]
Sepsis treatment
In contrast to dialysis, which works on the principle of the size related
The purification process is based on functionalized iron oxide or carbon coated metal nanoparticles with
The small size (< 100 nm) and large surface area of functionalized nanomagnets leads to advantageous properties compared to hemoperfusion, which is a clinically used technique for the purification of blood and is based on surface adsorption. These advantages are high loading and accessible for binding agents, high selectivity towards the target compound, fast diffusion, small hydrodynamic resistance, and low dosage.[57]
Tissue engineering
Nanotechnology may be used as part of tissue engineering to help reproduce or repair or reshape damaged tissue using suitable nanomaterial-based scaffolds and growth factors. Tissue engineering if successful may replace conventional treatments like organ transplants or artificial implants. Nanoparticles such as graphene, carbon nanotubes, molybdenum disulfide and tungsten disulfide are being used as reinforcing agents to fabricate mechanically strong biodegradable polymeric nanocomposites for bone tissue engineering applications. The addition of these nanoparticles in the polymer matrix at low concentrations (~0.2 weight %) leads to significant improvements in the compressive and flexural mechanical properties of polymeric nanocomposites.[58][59] Potentially, these nanocomposites may be used as a novel, mechanically strong, light weight composite as bone implants.[citation needed]
For example, a flesh welder was demonstrated to fuse two pieces of chicken meat into a single piece using a suspension of gold-coated
Vaccine development
Today, a significant part of vaccines against viral diseases are created using nanotechnology. Solid lipid nanoparticles are a novel delivery system for some vaccines against SARS-CoV-2 (the virus that causes COVID-19). To improve the immune response to targeted vaccine antigens, nanosized adjuvants have been widely used in recent decades. Inorganic nanoparticles of alum,[61] silica and clay, as well as organic nanoparticles based on polymers and lipids, are very popular adjuvants within modern vaccine formulations.[62] Nanoparticles of natural polymers such as chitosan are useful for vaccine development due to their biocompatibility and biodegradability.[63] Ceria nanoparticles appear very promising for both enhancing vaccine response and mitigating inflammation, since their adjuvanticity can be adjusted by changing nanoparticle parameters (size, crystallinity, surface state, stoichiometry, etc.).[64]
Medical devices
Neuro-electronic interfacing is a visionary goal dealing with the construction of nanodevices that will permit computers to be joined and linked to the nervous system. This idea requires the building of a molecular structure that will permit control and detection of nerve impulses by an external computer. A refuelable strategy implies energy is refilled continuously or periodically with external sonic, chemical, tethered, magnetic, or biological electrical sources, while a non-refuelable strategy implies that all power is drawn from internal energy storage which would stop when all energy is drained. A nanoscale enzymatic biofuel cell for self-powered nanodevices have been developed that uses glucose from biofluids including human blood and watermelons.[65] One limitation to this innovation is the fact that electrical interference or leakage or overheating from power consumption is possible. The wiring of the structure is extremely difficult because they must be positioned precisely in the nervous system. The structures that will provide the interface must also be compatible with the body's immune system.[66]
Cell repair machines
See also
- British Society for Nanomedicine
- Colloidal gold
- Heart nanotechnology
- IEEE P1906.1 – Recommended Practice for Nanoscale and Molecular Communication Framework
- Impalefection
- Monitoring (medicine)
- Nanobiotechnology
- Nanoparticle–biomolecule conjugate
- Nanozymes
- Nanotechnology in fiction
- Photodynamic therapy
- Top-down and bottom-up design
References
- ^ ISBN 978-1-57059-645-2. Archived from the original on 14 August 2015. Retrieved 24 April 2007.[page needed]
- PMID 29186662.
- S2CID 204266885.
- S2CID 40337130.
- PMID 17292052.
- ISBN 978-2-88449-080-1.[page needed]
- ^ "Nanomedicine overview". Nanomedicine, US National Institutes of Health. 1 September 2016. Retrieved 8 April 2017.
- ^ "Market report on emerging nanotechnology now available". Market Report. US National Science Foundation. 25 February 2014. Retrieved 7 June 2016.
- ^ PMID 22403487.
- PMID 30231877.
- S2CID 1490060.
- S2CID 15557853.
- .
- PMID 32344838.
- PMID 30451076.
- PMID 24852093.
- S2CID 39013016.
- PMID 22392910.
- PMID 23219874.
- S2CID 27774457.
- ^ PMID 22001607.
- PMID 21918982.
- PMID 18654442.
- PMID 26601235.
- .
- PMID 20225250.
- PMID 22745541.
- PMID 32727028.
- S2CID 35821474.
- PMID 23429269.
- PMID 26641016.
- ^ PMID 32264431.
- ISSN 1773-2247.
- PMID 33061580.
- ^ FDA (October 2012). "Highlights of Prescribing Information, Abraxane for Injectable Suspension" (PDF).
- ^ "Paclitaxel (Abraxane)". U.S. Food and Drug Administration. 11 October 2012. Retrieved 10 December 2012.
- ^ "FDA approves Abraxane for late-stage pancreatic cancer". FDA Press Announcements. FDA. 6 September 2013.
- .
- ^ "FDA approves new treatment for advanced pancreatic cancer". News Release. FDA. 22 October 2015. Archived from the original on 24 October 2015.
- S2CID 18043667.
- ^ PMID 26294304.
- ^ PMID 23525298.
- PMID 24085009.
- ^ Coffey R (August 2010). "20 Things You Didn't Know About Nanotechnology". Discover. 31 (6): 96.
- PMID 27960352.
- S2CID 20697208.
- ISBN 978-1-59102-287-9.[page needed]
- ^ Bullis K (31 October 2005). "Drug Store Cancer Tests". MIT Technology Review. Retrieved 8 October 2009.
- ^ Keller J (2013). "Nanotechnology has also helped to personalize oncology for the detection, diagnosis, and treatment of cancer. It is now able to be tailored to each individual's tumor for better performance". Military & Aerospace Electronics. 23 (6): 27.
- ^ S2CID 691647.
- ^ Bichitra Nandi Ganguly (July 2018). Nanomaterials in Bio-Medical Applications: A Novel approach. Materials research foundations. Vol. 33. Millersville, PA: Materials Research Forum LLC.
- S2CID 16125089.
- S2CID 11961534.
- PMID 23367876.
- S2CID 136900817.
- PMID 19370233.
- PMID 19839814.
- PMID 23405887.
- PMID 23727293.
- S2CID 4648228.
- PMID 35471916.
- PMID 37514991.
- PMID 37362954.
- ISSN 2772-4174.
- ^ "A nanoscale biofuel cell for self-powered nanotechnology devices". Nanowerk. 3 January 2011.
- ^ ISBN 978-1-57059-700-8.[page needed]
- ^ Freitas Jr RA, Merkle RC (2006). "Nanofactory Collaboration". Molecular Assembler.
- OCLC 57201348.[page needed]
- ^ Feynman RP (December 1959). "There's Plenty of Room at the Bottom". Archived from the original on 11 February 2010. Retrieved 23 March 2016.