Medroxyprogesterone
Progestin; Progestogen | |
ATC code |
|
---|---|
Legal status | |
Legal status | |
Identifiers | |
| |
JSmol) | |
| |
|
Medroxyprogesterone (MP), is a
progestin which is not used medically.[2][3][4][5] A derivative, medroxyprogesterone acetate (MPA), is used as a medication in humans, and is far more widely known in comparison.[6] Medroxyprogesterone is sometimes used as a synonym for medroxyprogesterone acetate,[6] and what is almost always being referred to when the term is used is MPA and not medroxyprogesterone.[7]
Pharmacology
Pharmacodynamics
Compared to MPA, medroxyprogesterone is over two orders of magnitude less potent as a progestogen.[8] Medroxyprogesterone is also notable in that it is a minor metabolite of MPA.[9] In addition to its progestagenic activity, medroxyprogesterone is a weak antiandrogen in vitro on human androgen receptor.[10]
Compound | Ki |
EC50 a |
EC50b |
---|---|---|---|
Progesterone | 4.3 | 0.9 | 25 |
Medroxyprogesterone | 241 | 47 | 32 |
Medroxyprogesterone acetate | 1.2 | 0.6 | 0.15 |
Values are nM. a = Coactivator recruitment. b = Reporter cell line. |
Chemistry
Medroxyprogesterone, also known as 6α-methyl-17α-hydroxyprogesterone or as 6α-methyl-17α-hydroxypregn-4-en-3,20-dione, is a
17α-hydroxyprogesterone with a methyl group at the C6α position.[2][3] The generic name of medroxyprogesterone is a contraction of 6α-methyl-17α-hydroxyprogesterone. It is closely related to medrogestone as well as other unesterified 17α-hydroxyprogesterone derivatives such as chlormadinone, cyproterone, and megestrol.[2][3]
Society and culture
Generic names
Medroxyprogesterone is the
andBrand Name
Meprate 10 Tablets (practo)
References
- FDA. Retrieved 22 Oct 2023.
- ^ ISBN 978-1-4757-2085-3.
- ^ ISBN 978-3-88763-075-1.
- ISBN 978-0-7514-0499-9.
- ^ a b "Medroxyprogesterone".
- ^ a b "MedroxyPROGESTERone: Drug Information Provided by Lexi-Comp". Merck Manual. 2009-12-01. Retrieved 2010-07-08.
- PMID 1119869.
- ^ S2CID 24703323.
- PMID 1271819.
- S2CID 51622914.