Mepivacaine
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AHFS/Drugs.com | Consumer Drug Information |
MedlinePlus | a603026 |
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Mepivacaine /mɛˈpɪvəkeɪn/ is a local anesthetic[1] of the amide type. Mepivacaine has a reasonably rapid onset (less rapid than that of procaine) and medium duration of action (longer than that of procaine)[2][3] and is marketed under various trade names including Carbocaine and Polocaine.
Mepivacaine became available in the United States in the 1960s.
Mepivacaine is used in any infiltration and local anesthesia.
It is supplied as the hydrochloride salt of the
racemate,[4] which consists of R(-)-mepivacaine and S(+)-mepivacaine in equal proportions. These two enantiomers have markedly different pharmacokinetic properties.[4]
Mepivacaine was originally synthesized in Sweden at the laboratory of
Bofors Nobelkrut in 1956.[5]
References
- PMID 17195831.
- ^ "Procaine". go.drugbank.com. Retrieved 2023-06-27.
- ^ "Mepivacaine". go.drugbank.com. Retrieved 2023-06-27.
- ^ S2CID 22363370.
- S2CID 32119846.