Metabolic Score for Insulin Resistance
The Metabolic Score for Insulin Resistance (METS-IR) is a metabolic index developed with the aim to quantify peripheral insulin sensitivity in humans; it was first described under the name METS-IR by Bello-Chavolla et al. in 2018.[1][2] It was developed by the Metabolic Research Disease Unit at the Instituto Nacional de Ciencias Médicas Salvador Zubirán[3] and validated against the euglycemic hyperinsulinemic clamp and the frequently-sampled intravenous glucose tolerance test in Mexican population.[1] It is a non-insulin-based alternative to insulin-based methods to quantify peripheral insulin sensitivity and an alternative to SPINA Carb, the Homeostatic Model Assessment (HOMA-IR) and the quantitative insulin sensitivity check index (QUICKI). METS-IR is currently validated for its use to assess cardio-metabolic risk in Latino population.[1]
Derivation and validation
METS-IR was generated using
The index holds a significant
Comparison to other indexes
METS-IR was compared against other non-insulin-based methods to approximate insulin sensitivity including the Triglyceride-Glucose index (TyG),[6] the triglyceride to HDL-C ratio,[7] and the TyG-BMI index,[8] yielding a higher correlation and area under the receiving operating characteristic curve compared to these other measures.[1] When assessing its utility for identifying metabolic syndrome in Chinese subjects, Yu et al. suggested that the TyG and TG/HDL-C indexes had superior performance in their population owing to ethnic-specific variations in body composition.[9] Given the role of ethnicity in modifying the performance of insulin sensitivity fasting-based indexes, further evaluations in different populations are required to establish performance of non-insulin-based methods.[10]
See also
- Insulin resistance
- Homeostatic model assessment
- SPINA-GBeta
- SPINA-GR
- Disposition index
- Quantitative insulin sensitivity check index
- Diabetes mellitus
- Diabetes management
References
- ^ PMID 29535168.
- ^ Yılmaz, Abdulkerim; Kaya, Süheyla Uzun; Kalkan, Göknur; Öztürk, Banu; Şahin, Şafak; Kutlutürk, Faruk; Taşlıyurt, Türker; Bilir, Yeliz (2014-07-16). "Prevalence of Metabolic Syndrome and Insulin Resistance in Patients with Psoriasis". Journal of Contemporary Medicine. Turkey: Government of Turkey. pp. 1–5. Retrieved 2019-01-03.
- ^ "Unidad de Investigación de Enfermedades Metabólicas". www.innsz.mx. Retrieved 2019-01-03.
- PMID 10902801.
- PMID 30417578.
- PMID 20484475.
- PMID 21730284.
- PMID 26930652.
- PMID 19820012.
- PMID 23704681.