Metabolically healthy obesity
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Metabolically healthy obesity (MHO) is a disputed
Characteristics
No universally accepted criteria exist to define putative MHO,
MHO individuals display less visceral adipose tissue, smaller adipocytes, and a reduced inflammatory profile relative to metabolically unhealthy obese individuals.[3][4][5] As a result, it has been argued that cardiometabolic risk might not improve significantly as a result of weight loss interventions.[6]
Epidemiology
Prevalence estimates of MHO have varied from 6 to 75 percent,[7] and it has been argued that between 10 and 25 percent of obese individuals are metabolically healthy.[8] One study found that 47.9% of obese people had MHO, while another found that 11% did.[3] It seems to be more prevalent in women than men, and its prevalence decreases with age.[9][10]
Outcomes
Some research suggests that metabolically healthy obese individuals are at an increased risk of several adverse outcomes when compared to individuals of a normal weight, including type 2 diabetes,[11] depressive symptoms,[12] and cardiovascular events.[13][14] Other research also suggests that although MHO individuals display a favorable metabolic profile, this does not necessarily translate into a decrease in mortality.[15] Research to date has produced conflicting results with respect to cardiovascular disease and mortality.[16] MHO individuals are at a higher risk of cardiovascular disease compared to metabolically healthy non-obese individuals, but they are also at a lower risk thereof than individuals who are both unhealthy and obese.[17][18] A 2016 meta-analysis found that MHO individuals were not at an increased risk of all-cause mortality (but were at an increased risk of cardiovascular events).[19] The relatively low risk of cardiovascular disease among people with MHO relative to metabolically unhealthy obese people has been attributed to differences in white adipose tissue function between the two groups.[20]
See also
References
- ^ PMID 24794116.
- ^ PMID 24622321.
- ^ PMID 23068072.
- PMID 25418549.
- PMID 27258304.
- PMID 25012199.
- S2CID 825441.
- S2CID 2054728.
- PMID 25038727.
- PMID 24484869.
- PMID 24661566.
- PMID 24296976.
- S2CID 9431877.
- S2CID 6085134.
- PMID 20975726.
- S2CID 489228.
- PMID 24400816.
- PMID 23972953.
- S2CID 21145367.
- PMID 25411437.