Metabotropic glutamate receptor 6

Source: Wikipedia, the free encyclopedia.
GRM6
Identifiers
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Ensembl
UniProt
RefSeq (mRNA)

NM_000843

NM_173372

RefSeq (protein)

NP_000834

NP_775548

Location (UCSC)Chr 5: 178.98 – 179 MbChr 11: 50.74 – 50.76 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Glutamate receptor, metabotropic 6, also known as GRM6 or mGluR6, is a protein which in humans is encoded by the GRM6 gene.[5][6]

Function

L-

cyclic AMP cascade but differ in their agonist selectivities.[5]

mGluR6 is specifically expressed in the retina, in a subtype of bipolar cells that depolarize in response to light, known as ON bipolar cells. These cells form synapses with photoreceptor cells, and detect the neurotransmitter glutamate via a GPCR signal transduction cascade. The glutamate receptor mGluR6 is located post-synaptically at the tips of the bipolar cell dendrites, and is responsible for initiating a signaling cascade that ultimately controls gating of the TRPM1 channel.[7][8] In human patients, mutations in the GRM6 gene are associated with congenital stationary night blindness.[9][10]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000113262 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000000617 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: GRM6 glutamate receptor, metabotropic 6".
  6. S2CID 25387864
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Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.