Metal fume fever
Metal fume fever | |
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Specialty | Emergency medicine |
Metal fume fever, also known as brass founders' ague, brass shakes,[1] zinc shakes, galvie flu, galvo poisoning, metal dust fever, welding shivers, or Monday morning fever,[2] is an illness primarily caused by exposure to chemicals such as zinc oxide (ZnO), aluminium oxide (Al2O3), or magnesium oxide (MgO) which are produced as byproducts in the fumes that result when certain metals are heated. Other common sources are fuming silver, gold, platinum,[3] and chromium.[4]
Signs and symptoms
The signs and symptoms are generally
Cause
Exposure usually arises through hot metalworking processes, such as smelting and casting of zinc alloys, welding of galvanized metals, brazing, or soldering. If the metal concerned is particularly high-risk, the residue from cold sanding processes may also cause fume fever, even if the dose is lower. It may also be caused by electroplated surfaces or metal-rich anti-corrosion paint, such as cadmium passivated steel or zinc chromate primer on aluminium aircraft parts. Exposure has also been reported in use of lead-free ammunition, by the harder steel core stripping metal from the jacket of the bullet and barrel of the rifle.[10]
The most plausible metabolic source of the symptoms is a dose-dependent release of certain
Diagnosis
Diagnosis is primarily anecdotal, that is, it depends upon a good occupational history. Diagnosis of metal fume fever can be easily missed because the complaints are non-specific, resemble a number of other common illnesses, and presentation occurs typically 2–10 hours after the exposure.[12] When respiratory symptoms are prominent, metal fume fever may be confused with acute bronchitis or pneumonia. The diagnosis is based primarily upon a history of exposure to metal oxide fumes. Cain and Fletcher (2010) report a case of metal fume fever that was diagnosed only by taking a full occupational history and by close collaboration between primary and secondary health care personnel.[13]
Physical symptoms vary among persons exposed, depending largely upon the stage in the course of the syndrome during which examination occurs. Patients may present with wheezing or crackles in the lungs. They typically have an increased white blood cell count, and urine, blood plasma and skin zinc levels may be elevated. Chest X-ray abnormalities may also be present.[11]
An interesting feature of metal fume fever involves rapid adaptation to the development of the syndrome following repeated metal oxide exposure. Workers with a history of recurrent metal fume fever often develop a tolerance to the fumes. This tolerance, however, is transient, and only persists through the work week. After a weekend hiatus, the tolerance has usually disappeared. This phenomenon of tolerance is what led to the name "Monday Fever".[citation needed]
In 2018, there were 259 cases of metal fume fever reported to the United States
Treatment
Treatment of mild metal fume fever consists of bedrest, keeping the patient well hydrated, and symptomatic therapy (e.g.
The consumption of large quantities of
Prevention
Prevention of metal fume fever in workers who are at risk (such as welders) involves avoidance of direct contact with potentially toxic fumes, improved engineering controls (exhaust ventilation systems), personal protective equipment (respirators), and education of workers regarding the features of the syndrome itself and proactive measures to prevent its development.[16]
In some cases, the product's design may be changed so as to eliminate the use of risky metals. Cadmium is often replaced by other metals.
See also
References
- ^ ISBN 0-9702203-2-4.
- PMID 11971851.
- PMID 12937186.
- ^ "Chromium and you" (PDF). Health and Safety Executive. 2013.
- ^ "Welding, Cutting, Brazing | Environmental Health & Safety - The University of Alabama". ehs.ua.edu. Retrieved 2016-06-14.
- ^ "Cadmium and you - working with Cadmium - are you at risk?" (PDF). Health and Safety Executive. 2010.
- ^ http://www.racgp.org.au/afp/201203/201203Wong.pdf[dead link][full citation needed]
- ^ "Medline Medical Encyclopedia: Zinc"
- ^ "Zinc oxide (UK PID)". inchem.org. Retrieved 2023-01-12.
- ^ "Blyfri ammunisjon og helseplager - Forsvaret.no". Archived from the original on 2011-05-31. Retrieved 2011-07-05.[full citation needed]
- ^ PMID 21921392.
- S2CID 21977121.
- PMID 20407044.
- S2CID 208227320. Retrieved 2020-04-03.
- ^ "Illness caused by welding fume and gases". Health and Safety Executive (UK). Retrieved 9 May 2013.
- ^ "Welding Fume Extraction". AES Industrial Supplies Limited. Retrieved 2021-04-20.