Metaraminol

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Metaraminol
Clinical data
Trade namesAramine, Metaramin, Pressonex
AHFS/Drugs.comInternational Drug Names
License data
Pregnancy
category
  • AU: C
endotracheal
ATC code
Legal status
Legal status
Pharmacokinetic data
Bioavailabilityn/a
Protein binding~45%
MetabolismLiver
Identifiers
  • (1R,2S)-3-[-2-amino-1-hydroxy-propyl]phenol
JSmol)
  • O[C@H](c1cc(O)ccc1)[C@@H](N)C
  • InChI=1S/C9H13NO2/c1-6(10)9(12)7-3-2-4-8(11)5-7/h2-6,9,11-12H,10H2,1H3/t6-,9-/m0/s1 checkY
  • Key:WXFIGDLSSYIKKV-RCOVLWMOSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Metaraminol, previously sold under the brand name Aramine among others and also known as metaradrine, is a

sympathomimetic amine used in the prevention and treatment of hypotension, particularly as a complication of anesthesia. It is an α1-adrenergic receptor agonist with some β-adrenergic effect.[2] It is currently sold in its generic form by Slayback Pharma.[3]

Pharmacology and use as a vasopressor

Metaraminol is given

intravenously as either a bolus (often 0.5–1 mg doses) or as an infusion, usually via peripheral intravenous access. Metaraminol is commonly available as 10 mg in 1 mL, that requires dilution prior to administration (often made up to a 0.5 mg/mL solution), however pre-prepared syringes of metaraminol for bolus use for hypotension are also commonly available.[4][5]

A commercially prepared pre-filled syringe of metaraminol for bolus use during anaesthesia, made up as 0.5 mg/mL (2.5 mg in 5 mL).

Pharmacodynamics

The dominant mechanism for the

α1 adrenergic effects predominate, such that reflex bradycardia
is a common side-effect.

Research

Metaraminol is also used in the treatment of priapism.[8][9][10]

References

  1. ^ "Injection : Aramine (Metaraminol Bitartrate)" (PDF). U.S. Food and Drug Administration (FDA). Retrieved 12 March 2022.
  2. PMID 12961786
    .
  3. United States Food and Drug Administration
    . 24 August 2021. Retrieved 13 August 2022.
  4. ^ "Metaraminol 0.5 mg/ml, Solution for Injection in pre-filled syringe - Summary of Product Characteristics (SmPC) - (emc)". www.medicines.org.uk. Retrieved 19 October 2022.
  5. ^ Goodrick N, Wentrup T, Messer G, Gleeson P, Culwick M, Goulding G (21 August 2020). "Pre-filled emergency drugs: The introduction of pre-filled metaraminol and ephedrine syringes into the main operating theatres of a major metropolitan centre". Australasian Anaesthesia (2013): 127–134.
  6. ^ a b "Metaraminol". Deranged Physiology. Retrieved 19 October 2022.
  7. PMID 14065947
    .
  8. PMID 15703094
    .
  9. PMID 2258979
    .
  10. PMID 3140463
    .

External links
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