Michael F. Holick
Michael F. Holick | |
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Boston University Medical Center |
Michael F. Holick (
Professional activities
After earning a Ph.D. degree in biochemistry, a medical degree, and completing a research postdoctoral fellowship at the University of Wisconsin–Madison, Holick completed a residency in medicine at the Massachusetts General Hospital in Boston.[2]
He is an adult
Holick serves as chair of NASA's "Human Health Countermeasures Element" Standing Review Panel,[5] chair of the Endocrine Practice Guidelines Committee for Vitamin D,[6] and editor-in-chief of the medical journal Clinical Laboratory.[7]
Academic achievements and research
Holick made discoveries in the field of vitamin D that have led to novel therapies for
His scientific work increased awareness in the pediatric and medical communities regarding vitamin D deficiency,
He has been quoted and his scientific work has been referenced in He wrote several books about the importance of vitamin D and its beneficial health effects to the broad public, and discussed the benefits of sensible and the risks of excessive
As a graduate student, he identified the major circulating form of vitamin D,
As a fellow, he participated in the first chemical synthesis of 1,25-dihydroxyvitamin D3
Holick helped develop the first clinical assays for 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D,[35] determined how vitamin D3 is made in the skin from sun exposure,[36] and established how season,[37] time of day,[38] skin pigmentation,[39] sunscreen use,[40] and latitude[37] influenced this vital cutaneous process. He established that the skin was not only the organ responsible for making vitamin D3[36] but was also a target tissue for its active form, 1,25-dihydroxyvitamin D3.[41] He determined the extremely inhibitory effects of 1,25-dihydroxyvitamin D3 on keratinocyte proliferation and the promoting effects on differentiation,[41] and translated these seminal observations by demonstrating that the topical application of 1,25-dihydroxyvitamin D3 and several of its analogs were effective for the treatment of psoriasis.[42]
He demonstrated that
He developed a vitamin D absorption test[46] and demonstrated that vitamin D was bioavailable in orange juice, leading to fortification of juice products in the United States.[47] He also used the test to demonstrate the major cause of vitamin D deficiency in obesity is sequestration of vitamin D in the fat.[48]
He helped perform dose escalation studies establishing how much vitamin D is required to maintain blood levels of 25-hydroxyvitamin D in the sufficient range for adults. These studies also demonstrated that up to 10,000 IU of vitamin D a day for 5 months did not cause toxicity.[49]
Controversies
Holick has been involved in several medical controversies. While at Boston University, he was asked to leave the Division of Dermatology because of his promoting the medical benefits of sun exposure. He accepted research funding for this work from a non-profit tanning bed company, considered by many to be an important potential bias. Barbara Gilchrest, then head of the department at Boston University, called Holick's book "shlock science" and Holick "a poster boy for the tanning industry".[50]
Holick received nearly $163,000 from 2013 to 2017 from pharmaceutical companies, according to Medicare’s Open Payments database, which tracks payments from drug and device manufacturers. The companies paying him included
Holick has also been criticized by other physicians because of his testimony, defending accused child abusers by asserting that Ehlers–Danlos syndrome is a cause of non-traumatic fractures in infancy (rather than abuse).[52] In one case of a child who had suffered broken bones in which Holick defended the accused parent, the child later went on to suffer severe brain injury, for which the parent, named Robert Marvin Ray, has been indicted.[50][53][54][55]
Since May 2017, Holick has been barred from evaluating or treating children by Boston Medical Center, which subsequently reported him to the Massachusetts Board of Registration in Medicine for "health care facility discipline",[54] but is still allowed to evaluate children who are participating in his research project.[55] Boston University has defended Holick's right to testify in courts, as part of his academic freedom.[55]
Holick has speculated that the dinosaurs may have died of rickets and osteomalacia caused by a lack of vitamin D in reduced sunlight.[56]
Awards
Holick has been awarded for his contributions to the field of vitamin D research with prizes,[57] including:
- Merit Award from the National Institute of Health
- American Society for Bone and Mineral Research Fuller Albright Award
- Mead Johnson Award
- Osborne and Mendel Award, the McCollum Award
- Robert H. Herman Award from the American Society for Clinical Nutrition
- ACN Award from the American College of Nutrition
- NIH’s General Clinical Research Center's Program Award for Excellence in Clinical Research
- Psoriasis Research Achievement Award from the American Skin Association[2]
- DSM Innovation in Nutrition Award[58]
- Van Slyke Award from American Association for Clinical Chemistry[59]
- Linus Pauling Prize In Human Nutrition[60]
- Delbert A Fisher Research Scholar Award from the Endocrine Society[61]
- American College of Nutrition's Communication Media Award[62]
- Institute of Functional Medicine’s LPI Award 2007[63]
Selected publications
Books
- Holick, MF (2011). The Vitamin D Solution: A 3-Step Strategy to Cure Our Most Common Health Problems. Plume 1st edition. ISBN 978-0452296886.
- Holick, MF; Dawson-Hughes, B (2010) [2004]. Nutrition and Bone Health. Humana Press. ISBN 978-1617374517.
- Holick, MF, ed. (2010). Vitamin D: Physiology, Molecular Biology, and Clinical Applications (2nd ed.). Humana Press. ISBN 978-1603273008.
- Holick, MF; Jenkins, Mark (2005). UV Advantage (2nd ed.). IBOOKS. ISBN 978-1596879003.
Scientific journal articles
- Holick, MF (2007). "Vitamin D deficiency". N Engl J Med. 357 (3): 266–81. S2CID 18566028.
- Holick, MF (2006). "Resurrection of vitamin D deficiency and rickets". J Clin Invest. 116 (8): 2062–72. PMID 16886050.
- Pietras, SM; Obayan, BK; Chai, MH; Holick, MF (2010). "Vitamin D2 treatment for vitamin D deficiency and insufficiency for up to 6 years". Arch Intern Med. 169 (19): 1806–8. PMID 19858440.
- Biancuzzo, RM; Young, A; Bibuld, D; Cai, MH; Winter, RM; Klein, EK; Ameri, A; Reitz, R; Salameh, W; Chen, TC; Holick, MF (2010). "Fortification of orange juice with vitamin D(2) or vitamin D(3) is as effective as an oral supplement in maintaining vitamin D status in adults". Am J Clin Nutr. 91 (6): 1621–6. PMID 20427729.
- Holick, MF; Binkley, NC; Bischoff-Ferrari, HA; Gordon, CM; Hanley, DA; Heaney, RP; Murad, MH; Weaver, CM; et al. (2011). "Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline". J Clin Endocrinol Metab. 96 (7): 1911–30. PMID 21646368.
References
- ^ "Michael F Holick- Vitamin D Deficiency and Possible Role in Multiple Sclerosis". YouTube. Retrieved 23 May 2020.
- ^ a b c "med.harvard.edu - Biographical Sketch M.F. Holick" (PDF). Archived from the original (PDF) on 2010-06-27.
- ^ "Boston University School of Medicine, Michael F. Holick Ph.D., M.D." Archived from the original on 2012-06-10.
- ^ "Vitamin D and Bone Metabolism Unit at Boston University".
- ^ "Human Research Program 2010 Chair Standing Review Panel Meeting" (PDF).
- PMID 21646368.
- ^ "Journal of Clinical Laboratory - Editorial Board - Editor-In-Chief - MF Holick". Archived from the original on 2013-01-19.
- ^ "Harvard Catalyst Profiles: Michael Holick".
- PMID 18400738.
- ^ S2CID 18566028.
- ^ Solomon, Interview by Deborah (19 March 2010). "Dr. Sunshine". The New York Times.
- ^ "Update on Fibromyalgia and Vitamin D". Forbes.
- ^ "Why You Should Be Getting More Sun". Forbes.
- ^ "The nature of nutrients". The Daily Beast. Archived from the original on 2012-01-25. Retrieved 2012-06-06.
- ^ "Get some sun". Archived from the original on 2013-11-05.
- ^ "Scientific American - The Vitamin D and sun debate". Scientific American.
- ^ "Bibliography M.F. Holick". Amazon.
- ^ "Books - Michael F. Holick". Amazon.
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- ^ PMID 6251551.
- ^ PMID 2839537.
- ^ Lu, Z; Chen, TC; Holick, MF (1992). Influence of season and time of day on the synthesis of vitamin D3. In: Holick MF, Kligman A, eds. Proceedings of the Biologic Effects of Light Symposium. pp. 53–6.
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- ^ PMID 2423618.
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- ^ a b David Armstrong (September 26, 2018). "The Child-Abuse Contrarian". The New Yorker. Retrieved 2018-09-30.
- ^ Szabo, Liz (2018-08-18). "Vitamin D, the Sunshine Supplement, Has Shadowy Money Behind It". New York Times. Retrieved 2018-10-07.
- ^ Jenifer McKim (March 13, 2015). "Boston University researcher draws fire for claiming some broken bones caused by rare disease, not abuse". The Boston Globe. Retrieved 2017-11-25.
- ^ Shawn Cabbagestalk (January 11, 2018). "Midlands father charged with abusing infant daughter who suffered permanent brain damage". WCBD News 2. Retrieved 2018-09-30.
- ^ a b "Boston Hospital Reports Disciplining of Child Abuse Skeptic". Medscape. Retrieved 2019-08-02.
- ^ a b c Armstrong, David (2019-07-24). "Boston Hospital Reports Disciplining of Renowned Child Abuse Skeptic". ProPublica.
- ^ Szabo, Liz (18 August 2018). "Vitamin D, the Sunshine Supplement, Has Shadowy Money Behind It". The New York Times.
- ^ "The UV advantage - biography - awards". Archived from the original on 2011-09-03.
- ^ "DSM Nutrition Award 2009 presented to Michael Holick and Heike Bischoff-Ferrari". Archived from the original on 2013-03-12.
- ^ "American Association for Clinical Chemistry - 2010 Van Slyke Award".
- ^ "2009 Linus Pauling Institute Prize Recipient". Archived from the original on 2012-03-07.
- ^ "Dr. Holick honored by Endocrine Society".
- ^ "BUSM professor receives 2011 ACN Communication Media Award". 23 November 2011.
- ^ Institute of functional medicine (2020). "About the Linus Pauling Award". Institute of Functional Medicine.