Migraine
Migraine | |
---|---|
Usual onset | Around puberty[1] |
Duration | Recurrent, long term[1] |
Causes | Environmental and genetic[3] |
Risk factors | Family history, female[4][5] |
Differential diagnosis | Subarachnoid hemorrhage, venous thrombosis, idiopathic intracranial hypertension, brain tumor, tension headache, sinusitis,[6] cluster headache[7][unreliable medical source?] |
Prevention | Propranolol, amitriptyline, topiramate[8] |
Medication | Ibuprofen, paracetamol (acetaminophen), triptans, ergotamines[5][9] |
Prevalence | ~15%[10] |
Migraine (UK: /ˈmiːɡreɪn/, US: /ˈmaɪ-/)[11][12] is a genetically influenced complex neurological disorder characterized by episodes of moderate-to-severe headache, most often unilateral and generally associated with nausea and light and sound sensitivity.[1] Other characterizing symptoms may include nausea, vomiting, cognitive dysfunction, allodynia, and dizziness. Exacerbation of headache symptoms during physical activity is another distinguishing feature.[13] Up to one-third of migraine sufferers experience aura, a premonitory period of sensory disturbance widely accepted to be caused by cortical spreading depression at the onset of a migraine attack.[13] Although primarily considered to be a headache disorder, migraine is highly heterogenous in its clinical presentation and is better thought of as a spectrum disease rather than a distinct clinical entity.[14] Disease burden can range from episodic discrete attacks, consisting of as little as several lifetime attacks, to chronic disease.[14][15]
Migraine is believed to be caused by a mixture of environmental and genetic factors that influence the excitation and inhibition of
Initial recommended
Globally, approximately 15% of people are affected by migraine.[10] In the Global Burden of Disease Study, conducted in 2010, migraines ranked as the third-most prevalent disorder in the world.[25] It most often starts at puberty and is worst during middle age.[1] As of 2016[update], it is one of the most common causes of disability.[26]
Signs and symptoms
Migraine typically presents with self-limited, recurrent severe headache associated with autonomic symptoms.[5][27] About 15–30% of people living with migraine experience episodes with aura,[9][28] and they also frequently experience episodes without aura.[29] The severity of the pain, duration of the headache, and frequency of attacks are variable.[5] A migraine attack lasting longer than 72 hours is termed status migrainosus.[30] There are four possible phases to a migraine attack, although not all the phases are necessarily experienced:[13]
- The prodrome, which occurs hours or days before the headache
- The aura, which immediately precedes the headache
- The pain phase, also known as headache phase
- The postdrome, the effects experienced following the end of a migraine attack
Migraine is associated with
Prodrome phase
Aura phase
Aura is a transient focal neurological phenomenon that occurs before or during the headache.[2] Aura appears gradually over a number of minutes (usually occurring over 5–60 minutes) and generally lasts less than 60 minutes.[37][38] Symptoms can be visual, sensory or motoric in nature, and many people experience more than one.[39] Visual effects occur most frequently: they occur in up to 99% of cases and in more than 50% of cases are not accompanied by sensory or motor effects.[39] If any symptom remains after 60 minutes, the state is known as persistent aura.[40]
Visual disturbances often consist of a
Sensory aura are the second most common type; they occur in 30–40% of people with auras.
Pain phase
Classically the headache is unilateral, throbbing, and moderate to severe in intensity.
The pain is frequently accompanied by nausea, vomiting,
Silent migraine
Sometimes, aura occurs without a subsequent headache.[39] This is known in modern classification as a typical aura without headache, or acephalgic migraine in previous classification, or commonly as a silent migraine.[52][53] However, silent migraine can still produce debilitating symptoms, with visual disturbance, vision loss in half of both eyes, alterations in color perception, and other sensory problems, like sensitivity to light, sound, and odors.[54] It can last from 15 to 30 minutes, usually no longer than 60 minutes, and it can recur or appear as an isolated event.[53]
Postdrome
The migraine postdrome could be defined as that constellation of symptoms occurring once the acute headache has settled.[55] Many report a sore feeling in the area where the migraine was, and some report impaired thinking for a few days after the headache has passed. The person may feel tired or "hung over" and have head pain, cognitive difficulties, gastrointestinal symptoms, mood changes, and weakness.[56] According to one summary, "Some people feel unusually refreshed or euphoric after an attack, whereas others note depression and malaise."[57][unreliable medical source?]
Cause
The underlying causes of migraines are unknown.[58] However, they are believed to be related to a mix of environmental and genetic factors.[3] They run in families in about two-thirds of cases[5] and rarely occur due to a single gene defect.[59] While migraines were once believed to be more common in those of high intelligence, this does not appear to be true.[46] A number of psychological conditions are associated, including depression, anxiety, and bipolar disorder.[60]
Success of the surgical migraine treatment by decompression of extracranial sensory nerves adjacent to vessels[61] suggests that migraineurs may have anatomical predisposition for neurovascular compression that may be caused by both intracranial and extracranial vasodilation due to migraine triggers. This, along with the existence of numerous cranial neural interconnections,[62] may explain the multiple cranial nerve involvement and consequent diversity of migraine symptoms.[63]
Genetics
Studies of twins indicate a 34% to 51% genetic influence of likelihood to develop migraine.[3] This genetic relationship is stronger for migraine with aura than for migraines without aura.[29] A number of specific variants of genes increase the risk by a small to moderate amount.[59]
Triggers
Migraine may be induced by triggers, with some reporting it as an influence in a minority of cases[5] and others the majority.[69] Many things such as fatigue, certain foods, alcohol, and weather have been labeled as triggers; however, the strength and significance of these relationships are uncertain.[69][70] Most people with migraines report experiencing triggers.[71] Symptoms may start up to 24 hours after a trigger.[5]
Physiological aspects
Common triggers quoted are stress, hunger, and fatigue (these equally contribute to
Dietary aspects
Between 12% and 60% of people report foods as triggers.[75][76]
There are many reports[77][78][79][80][81] that tyramine – which is naturally present in chocolate, alcoholic beverages, most cheeses, processed meats, and other foods – can trigger migraine symptoms in some individuals. Monosodium glutamate (MSG) has been reported as a trigger for migraine,[82] but a systematic review concluded that "a causal relationship between MSG and headache has not been proven... It would seem premature to conclude that the MSG present in food causes headache".[83]
Environmental aspects
A 2009 review on potential triggers in the indoor and outdoor environment concluded that while there were insufficient studies to confirm environmental factors as causing migraine, "migraineurs worldwide consistently report similar environmental triggers".[84]
Pathophysiology
Migraine is believed to be primarily a neurological disorder,
Sensitization of trigeminal pathways is a key pathophysiological phenomenon in migraine. It is debatable whether sensitization starts in the periphery or in the brain.[96][97]
Aura
Cortical spreading depression, or spreading depression according to Leão, is a burst of neuronal activity followed by a period of inactivity, which is seen in those with migraines with aura.[98] There are a number of explanations for its occurrence, including activation of NMDA receptors leading to calcium entering the cell.[98] After the burst of activity, the blood flow to the cerebral cortex in the area affected is decreased for two to six hours.[98] It is believed that when depolarization travels down the underside of the brain, nerves that sense pain in the head and neck are triggered.[98]
Pain
The exact mechanism of the head pain which occurs during a migraine episode is unknown.[99] Some evidence supports a primary role for central nervous system structures (such as the brainstem and diencephalon),[100] while other data support the role of peripheral activation (such as via the sensory nerves that surround blood vessels of the head and neck).[99] The potential candidate vessels include dural arteries, pial arteries and extracranial arteries such as those of the scalp.[99] The role of vasodilatation of the extracranial arteries, in particular, is believed to be significant.[101]
Neuromodulators
Calcitonin gene-related peptides (CGRPs) have been found to play a role in the pathogenesis of the pain associated with migraine, as levels of it become elevated during an attack.[9][43]
Diagnosis
The diagnosis of a migraine is based on signs and symptoms.[5] Neuroimaging tests are not necessary to diagnose migraine, but may be used to find other causes of headaches in those whose examination and history do not confirm a migraine diagnosis.[106] It is believed that a substantial number of people with the condition remain undiagnosed.[5]
The diagnosis of migraine without aura, according to the International Headache Society, can be made according the "5, 4, 3, 2, 1 criteria," which is as follows:[13]
- Five or more attacks – for migraine with aura, two attacks are sufficient for diagnosis.
- Four hours to three days in duration
- Two or more of the following:
- Unilateral (affecting one side of the head)
- Pulsating
- Moderate or severe pain intensity
- Worsened by or causing avoidance of routine physical activity
- One or more of the following:
- Nausea and/or vomiting
- Sensitivity to both light (photophobia) and sound (phonophobia)
If someone experiences two of the following: photophobia, nausea, or inability to work or study for a day, the diagnosis is more likely.[107] In those with four out of five of the following: pulsating headache, duration of 4–72 hours, pain on one side of the head, nausea, or symptoms that interfere with the person's life, the probability that this is a migraine attack is 92%.[9] In those with fewer than three of these symptoms, the probability is 17%.[9]
Classification
Migraine was first comprehensively classified in 1988.[29]
The
Migraine is divided into six subclasses (some of which include further subdivisions):[110]
- Migraine without aura, or "common migraine", involves migraine headaches that are not accompanied by aura.
- Migraine with aura, or "classic migraine", usually involves migraine headaches accompanied by aura. Less commonly, aura can occur without a headache, or with a nonmigraine headache. Two other varieties are world spinning, ringing in ears, or a number of other brainstem-related symptoms, but not motor weakness. This type was initially believed to be due to spasms of the basilar artery, the artery that supplies the brainstem. Now that this mechanism is not believed to be primary, the symptomatic term migraine with brainstem aura (MBA) is preferred.[49] Retinal migraine(which is distinct from visual or optical migraine) involves migraine headaches accompanied by visual disturbances or even temporary blindness in one eye.
- Childhood periodic syndromes that are commonly precursors of migraine include cyclical vomiting (occasional intense periods of vomiting), abdominal migraine(abdominal pain, usually accompanied by nausea), and benign paroxysmal vertigo of childhood (occasional attacks of vertigo).
- Complications of migraine describe migraine headaches and/or auras that are unusually long or unusually frequent, or associated with a seizure or brain lesion.
- Probable migraine describes conditions that have some characteristics of migraines, but where there is not enough evidence to diagnose it as a migraine with certainty (in the presence of concurrent medication overuse).
- Chronic migraine is a complication of migraines, and is a headache that fulfills diagnostic criteria for migraine headache and occurs for a greater time interval. Specifically, greater or equal to 15 days/month for longer than 3 months.[111]
Abdominal migraine
The diagnosis of
Differential diagnosis
Other conditions that can cause similar symptoms to a migraine headache include
Those with stable headaches that meet criteria for migraines should not receive neuroimaging to look for other intracranial disease.[114][115][116] This requires that other concerning findings such as papilledema (swelling of the optic disc) are not present. People with migraines are not at an increased risk of having another cause for severe headaches.[citation needed]
Prevention
Preventive treatments of migraine include medications, nutritional supplements, lifestyle alterations, and surgery. Prevention is recommended in those who have headaches more than two days a week, cannot tolerate the medications used to treat acute attacks, or those with severe attacks that are not easily controlled.[9] Recommended lifestyle changes include stopping tobacco use and reducing behaviors that interfere with sleep.[117]
The goal is to reduce the frequency, painfulness, and duration of migraine episodes, and to increase the effectiveness of abortive therapy.[118][119] Another reason for prevention is to avoid medication overuse headache. This is a common problem and can result in chronic daily headache.[120][121]
Medication
Preventive migraine medications are considered effective if they reduce the frequency or severity of the migraine attacks by at least 50%.
The beta blocker
Tentative evidence also supports the use of
The
Medications in the
Alternative therapies
Acupuncture has a small effect in reducing migraine frequency, compared to sham acupuncture, a practice where needles are placed randomly or do not penetrate the skin.[134] Physiotherapy, massage and relaxation, and chiropractic manipulation might be as effective as propranolol or topiramate in the prevention of migraine headaches; however, the research had some problems with methodology.[135][136] Another review, however, found evidence to support spinal manipulation to be poor and insufficient to support its use.[137]
Tentative evidence supports the use of stress reduction techniques such as cognitive behavioral therapy, biofeedback, and relaxation techniques.[72] Regular physical exercise may decrease the frequency.[42] Numerous psychological approaches have been developed that are aimed at preventing or reducing the frequency of migraine in adults including educational approaches, relaxation techniques, assistance in developing coping strategies, strategies to change the way one thinks of a migraine attack, and strategies to reduce symptoms.[138] Other strategies include: progressive muscle relaxation, biofeedback, behavioral training, acceptance and commitment therapy, and mindfulness-based interventions.[139] The medical evidence supporting the effectiveness of these types of psychological approaches is very limited.[138]
Among alternative medicines,
Feverfew has traditionally been used as a treatment for fever, headache and migraine, women's conditions such as difficulties in labour and regulation of menstruation, relief of stomach ache, toothache and insect bites. During the last decades, it has mainly been used for headache and as a preventive treatment for migraine.[145] The plant parts used for medicinal use are the dried leaves or the dried aerial parts. Several historical data supports feverfew's traditional medicinal uses.[146] In addition, several clinical studies have been performed assessing the efficacy and safety of feverfew monotherapy in the prevention of migraine.[147] The majority of the clinical trials favoured feverfew over placebo. The data also suggest that feverfew is associated with only mild and transient adverse effects. The frequency of migraine was positively affected after treatment with feverfew. Reduction of migraine severity was also reported after intake of feverfew and incidence of nausea and vomiting decreased significantly. No effect of feverfew was reported in one study.[147]
There is tentative evidence for melatonin as an add-on therapy for prevention and treatment of migraine.[148][149] The data on melatonin are mixed and certain studies have had negative results.[148] The reasons for the mixed findings are unclear but may stem from differences in study design and dosage.[148] Melatonin's possible mechanisms of action in migraine are not completely clear, but may include improved sleep, direct action on melatonin receptors in the brain, and anti-inflammatory properties.[148][150]
Devices and surgery
Medical devices, such as
Management
There are three main aspects of treatment: trigger avoidance, acute symptomatic control, and medication for prevention.
For children, ibuprofen helps decrease pain and is the initially recommended treatment.[160][161] Paracetamol does not appear to be effective in providing pain relief.[160] Triptans are effective, though there is a risk of causing minor side effects like taste disturbance, nasal symptoms, dizziness, fatigue, low energy, nausea, or vomiting.[160][162] Ibuprofen should be used less than half the days in a month and triptans less than a third of the days in a month to decrease the risk of medication overuse headache.[161]
Analgesics
Recommended initial treatment for those with mild to moderate symptoms are simple analgesics such as nonsteroidal anti-inflammatory drugs (NSAIDs) or the combination of paracetamol (also known as acetaminophen), aspirin, and caffeine, although caffeine overuse can be a contributor to migraine chronification as well as a migraine trigger for many patients.[9][163] Several NSAIDs, including diclofenac and ibuprofen, have evidence to support their use.[164][165] Aspirin (900 to 1000 mg) can relieve moderate to severe migraine pain, with an effectiveness similar to sumatriptan.[166] Ketorolac is available in intravenous and intramuscular formulations.[9]
Paracetamol, either alone or in combination with
Naproxen by itself may not be effective as a stand-alone medicine to stop a migraine headache as it is only weakly better than a placebo medication in clinical trials.[170]
Antiemetics
Triptans
Most side effects are mild, including
Sumatriptan does not prevent other migraine headaches from starting in the future.[174] For increased effectiveness at stopping migraine symptoms, a combined therapy that includes sumatriptan and naproxen may be suggested.[178]
CGRP receptor antagonists
Calcitonin gene-related peptide receptor antagonists (CGRP) target calcitonin gene-related peptide or its receptor to prevent migraine headaches or reduce their severity.[38] CGRP is a signaling molecule as well as a potent vasodilator that is involved in the development of a migraine headache.[38] There are four injectable monoclonal antibodies that target CGRP or its receptor (eptinezumab, erenumab, fremanezumab, and galcanezumab) and the medications have demonstrated efficacy in the preventative treatment of episodic and chronic migraine headaches in phase III randomized clinical trials.[38]
Zavegepant was approved for medical use in the United States in March 2023.[179][180][181]
Ergotamines
Ergotamine and dihydroergotamine are older medications still prescribed for migraines, the latter in nasal spray and injectable forms.[5][182] They appear equally effective to the triptans[183] and experience adverse effects that typically are benign.[184] In the most severe cases, such as those with status migrainosus, they appear to be the most effective treatment option.[184] They can cause vasospasm including coronary vasospasm and are contraindicated in people with coronary artery disease.[185]
Magnesium
Magnesium is recognized as an inexpensive, over-the-counter supplement which can be part of a multimodal approach to migraine reduction. Some studies have shown to be effective in both preventing and treating migraine in intravenous form.[186] The intravenous form reduces attacks as measured in approximately 15–45 minutes, 120 minutes, and 24-hour time periods, magnesium taken orally alleviates the frequency and intensity of migraines.[187][188]
Other
Intravenous
Occipital nerve stimulation, may be effective but has the downsides of being cost-expensive and has a significant amount of complications.[191]
There is modest evidence for the effectiveness of non-invasive neuromodulatory devices, behavioral therapies and
Feverfew is registered as a traditional herbal medicine in the Nordic countries under the brand name Glitinum, only powdered feverfew is approved in the Herbal community monograph issued by European Medicines Agency (EMA).
Topiramate and botulinum toxin (Botox) have evidence in treating chronic migraine.[131][192] Botulinum toxin has been found to be useful in those with chronic migraine but not those with episodic ones.[193][194] The anti-CGRP monoclonal antibody erenumab was found in one study to decrease chronic migraines by 2.4 days more than placebo.[195]
Prognosis
"Migraine exists on a continuum of different attack frequencies and associated levels of disability."[196] For those with occasional, episodic migraine, a "proper combination of drugs for prevention and treatment of migraine attacks" can limit the disease's impact on patients' personal and professional lives.[197] But fewer than half of people with migraine seek medical care and more than half go undiagnosed and undertreated.[198] "Responsive prevention and treatment of migraine is incredibly important" because evidence shows "an increased sensitivity after each successive attack, eventually leading to chronic daily migraine in some individuals."[197] Repeated migraine results in "reorganization of brain circuitry," causing "profound functional as well as structural changes in the brain."[199] "One of the most important problems in clinical migraine is the progression from an intermittent, self-limited inconvenience to a life-changing disorder of chronic pain, sensory amplification, and autonomic and affective disruption. This progression, sometimes termed chronification in the migraine literature, is common, affecting 3% of migraineurs in a given year, such that 8% of migraineurs have chronic migraine in any given year." Brain imagery reveals that the electrophysiological changes seen during an attack become permanent in people with chronic migraine; "thus, from an electrophysiological point of view, chronic migraine indeed resembles a never-ending migraine attack."[199] Severe migraine ranks in the highest category of disability, according to the World Health Organization, which uses objective metrics to determine disability burden for the authoritative annual Global Burden of Disease report. The report classifies severe migraine alongside severe depression, active psychosis, quadriplegia, and terminal-stage cancer.[200]
Migraine with aura appears to be a risk factor for
Epidemiology
Migraine is common, with around 33% of women and 18% of men affected at some point in their lifetime.[208] Onset can be at any age, but prevalence rises sharply around puberty, and remains high until declining after age 50.[208] Before puberty, boys and girls are equally impacted, with around 5% of children experiencing migraines. From puberty onwards, women experience migraines at greater rates than men. From age 30 to 50, up to 4 times as many women experience migraines as men.[208]
Worldwide, migraine affects nearly 15% or approximately one billion people.[10] In the United States, about 6% of men and 18% of women experience a migraine attack in a given year, with a lifetime risk of about 18% and 43% respectively.[5] In Europe, migraines affect 12–28% of people at some point in their lives with about 6–15% of adult men and 14–35% of adult women getting at least one yearly.[209] Rates of migraine are slightly lower in Asia and Africa than in Western countries.[46][210] Chronic migraine occurs in approximately 1.4 to 2.2% of the population.[211]
In women, migraine without aura are more common than migraine with aura; however in men the two types occur with similar frequency.[46]
During
History
An early description consistent with migraine is contained in the Ebers Papyrus, written around 1500 BCE in ancient Egypt.[213]
The word migraine is from the Greek ἡμικρᾱνίᾱ (hēmikrāníā), 'pain in half of the head',[214] from ἡμι- (hēmi-), 'half' and κρᾱνίον (krāníon), 'skull'.[215]
In 200 BCE, writings from the Hippocratic school of medicine described the visual aura that can precede the headache and a partial relief occurring through vomiting.[216]
A second-century description by
While many treatments for migraine have been attempted, it was not until 1868 that use of a substance which eventually turned out to be effective began.[216] This substance was the fungus ergot from which ergotamine was isolated in 1918.[223] Methysergide was developed in 1959 and the first triptan, sumatriptan, was developed in 1988.[223] During the 20th century with better study-design, effective preventive measures were found and confirmed.[216]
Society and culture
Migraine is a significant source of both medical costs and lost productivity. It has been estimated that migraine is the most costly neurological disorder in the European Community, costing more than €27 billion per year.
Research
Potential prevention mechanisms
Potential sex dependency
While no definitive proof has been found linking migraine to sex, statistical data indicates that women may be more prone to having migraine, showing migraine incidence three times higher among women than men.[230][231] The Society for Women's Health Research has also mentioned hormonal influences, mainly estrogen, as having a considerable role in provoking migraine pain. Studies and research related to the sex dependencies of migraine are still ongoing, and conclusions have yet to be achieved.[232][233][234]
See also
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Further reading
- Ashina M (November 2020). Ropper AH (ed.). "Migraine". The New England Journal of Medicine. 383 (19): 1866–1876. S2CID 227078662.
- Oskoui M, Pringsheim T, Billinghurst L, Potrebic S, Gersz EM, Gloss D, et al. (September 2019). "Practice guideline update summary: Pharmacologic treatment for pediatric migraine prevention: Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology and the American Headache Society". Neurology. 93 (11): 500–509. PMID 31413170.
- Oskoui M, Pringsheim T, Holler-Managan Y, Potrebic S, Billinghurst L, Gloss D, et al. (September 2019). "Practice guideline update summary: Acute treatment of migraine in children and adolescents: Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology and the American Headache Society". Neurology. 93 (11): 487–499. S2CID 199662718.
External links
External audio | |
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Sex(ism), Drugs, and Migraines, Distillations Podcast, Science History Institute, 15 January 2019 |
- Migraine at Curlie