Mildred Cohn

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Mildred Cohn
Philadelphia, Pennsylvania, US
Alma materHunter College, Columbia University
SpouseHenry Primakoff
ChildrenThree
Parents
  • Isidore Cohn (father)
  • Bertha Klein Cohn (mother)
AwardsGarvan–Olin Medal (1963)
Elliott Cresson Medal (1975),
National Medal of Science (1982)
Scientific career
FieldsPhysical Biochemistry
InstitutionsNational Advisory Committee for Aeronautics
University of Pennsylvania
Washington University School of Medicine
Doctoral advisorHarold Urey

Mildred Cohn (July 12, 1913 – October 12, 2009)[1][2] was an American biochemist who furthered understanding of biochemical processes through her study of chemical reactions within animal cells. She was a pioneer in the use of nuclear magnetic resonance for studying enzyme reactions, particularly reactions of adenosine triphosphate (ATP).[3]

She received the nation's highest science award, the National Medal of Science, in 1982,[4] and was inducted into the National Women's Hall of Fame.

Early life

Cohn's parents, childhood sweethearts Isidore Cohn and Bertha Klein Cohn,

Jewish. Her father was a rabbi. They left Russia for the United States around 1907. Mildred Cohn was born July 12, 1913, in the Bronx, where her family lived in an apartment. When Mildred was 13, her father moved the family to a Yiddish-speaking cooperative, Heim Gesellschaft, which strongly emphasized education, the arts, social justice, and the preservation of Yiddish culture.[5]

Education

Cohn graduated from high school at 14.[6] She went on to attend

PhD in physical chemistry in 1938.[9]

Career

External videos
video icon “I didn’t intend to be an assistant for the rest of my life; so I started a new field of research”, talk given at the Science History Institute in 2005.

With Urey's recommendation, Cohn was able to obtain a position as a research associate in the laboratory of Vincent du Vigneaud at Washington University in St. Louis. There Cohn conducted post-doctoral studies on sulfur-amino acid metabolism using radioactive sulfur isotopes. Cohn pioneered the use of isotopic tracers to examine the metabolism of sulfur-containing compounds.[10] When du Vigneaud moved his laboratory to Cornell University Medical College in New York City, Cohn and her new husband, physicist Henry Primakoff, moved to New York as well.[7][11]

In 1946,

divalent ions in the enzymatic conversion of ATP and ADP.[12]

When asked in later life about her most exciting moments in science, Cohn replied: "In 1958, using nuclear magnetic resonance, I saw the first three peaks of ATP. That was exciting. [I could] distinguish the three phosphorus atoms of ATP with a spectroscopic method, which had never been done before."

divalent metal ions are involved in the enzymatic reactions of ADP and ATP by studying NMR spectra of the phosphorus nuclei and the structural change in the presence of various divalent ions.[10]

In 1958, she was promoted from research associate to associate professor.[7] In 1960, Cohn and her husband joined the University of Pennsylvania. Mildred was appointed as an associate professor of Biophysics and Physical Biochemistry, and became a full professor the following year.[2][11] In 1964, she became the first woman to receive the American Heart Association's Lifetime Career Award, providing support until she reached age sixty-five.[13] In 1971, she was elected to the National Academy of Sciences.[7] She was elected to the American Philosophical Society the following year.[14] In 1982, she retired from the faculty as the Benjamin Rush Professor Emerita of Physiological Chemistry.[11] In 1984, Cohn received the Golden Plate Award of the American Academy of Achievement.[15]

In the course of her career, Mildren Cohn worked with four Nobel laureates, who received three Nobel prizes:

Achievements

Attending the Brown Bag Lecture in 2005

Cohn wrote 160 papers, mostly on her primary research subject of using nuclear magnetic resonance to study ATP.[12] She received a number of honorary doctorates.

She won the American Chemical Society's

Garvan-Olin Medal in 1963.[18] In 1968, she was elected a Fellow of the American Academy of Arts and Sciences.[19] She was awarded the Franklin Institute's Elliott Cresson Medal in 1975, for her work on nuclear magnetic resonance analysis of enzymatic complexes. She received the International Organization of Women Biochemists Award[20] in 1979.[6] She received Columbia University's Chandler Medal in 1986.[21]

She was presented with the National Medal of Science by President Ronald Reagan in 1983 for 'pioneering the use of stable isotopic tracers and nuclear magnetic resonance spectroscopy in the study of the mechanisms of enzymatic catalysis'.[22]

During her career, Cohn achieved several gender firsts: She was the first woman to be appointed to the editorial board of the

Seneca Falls, New York.[2][26]

Marriage

Mildred Cohn was married to physicist Henry Primakoff from 1938 until his death in 1983.[4] They had three children, all of whom earned doctorates.[7] Mildren Cohn is quoted in Elga Wasserman's book, The Door in the Dream: Conversations With Eminent Women in Science, as saying “My greatest piece of luck was marrying Henry Primakoff, an excellent scientist who treated me as an intellectual equal and always assumed that I should pursue a scientific career and behaved accordingly.”[1][7]

Partial bibliography

  • Cohn, Mildred; Hughes, T. R. (1960). "Phosphorus magnetic resonance spectra of adenosine diphosphate and triphosphate. I. Effect of PH". The Journal of Biological Chemistry. 235: 3250–3.
    doi:10.1016/S0021-9258(20)81346-5
    .
  • Cohn, Mildred; Hughes, T. R. (1962). "Nuclear magnetic resonance spectra of adenosine di- and triphosphate. II. Effect of complexing with divalent metal ions". The Journal of Biological Chemistry. 237: 176–81.
    PMID 13880359
    .
  • Cohn, Mildred (1953). "A study of oxidative phosphorylation with 0-18 labeled inorganic phosphate". The Journal of Biological Chemistry. 201 (2): 735–50.
    PMID 13061412
    .

Further reading

References

  1. ^ a b Schudel, Matt (October 23, 2009). "Mildred Cohn, 96; acclaimed scientist overcame bias". Washington Post.
  2. ^ a b c d Martin, Douglas (November 11, 2009). "Mildred Cohn, Biochemist, Is Dead at 96". The New York Times. Retrieved November 11, 2009.
  3. ^
    ISBN 9780816061587. Archived from the original
    on 2013-11-10. Retrieved 2017-09-10.
  4. ^ a b Maugh, Thomas H. (2009-10-13). "Mildred Cohn dies at 96; chemist applied physics to problems of biology, earned National Medal of Science". Los Angeles Times.
  5. ^ Mildred Cohn, Ph.D.: The Science of Fearlessness, Video, 18 min 43 sec, Science History Institute, Philadelphia, PA
  6. ^
    Chemical Heritage Foundation
    .
  7. ^
    ISBN 0309086191
    .
  8. ^ a b "The Nobel Prize in Chemistry 1934: Harold C. Urey". The Nobel Foundation. 1934.
  9. ^ "Mildren Cohn (1913–2009)". American Chemical Society.
  10. ^
    PMID 19891052
    .
  11. ^ a b c d e "Mildred Cohn (b. 1913)". Bernard Becker Medical Library.
  12. ^ a b c Johnson, Erica P. (2003-10-06). "First Person | Mildred Cohn (Interview)". The Scientist.
  13. ^ Barrer, Betty. "Mildred Cohn". Jewish Women's Archive.
  14. ^ "APS Member History". search.amphilsoc.org. Retrieved 2022-08-23.
  15. American Academy of Achievement
    .
  16. ^ "The Nobel Prize in Physiology or Medicine 1947: Carl Cori, Gerty Cori, Bernardo Houssay". The Nobel Foundation. 1947.
  17. ^ "The Nobel Prize in Chemistry 1955: Vincent du Vigneaud". The Nobel Foundation. 1955.
  18. ^ "Francis P. Garvan-John M. Olin Medal". American Chemical Society.
  19. ^ "Book of Members, 1780–2010: Chapter C" (PDF). American Academy of Arts and Sciences. Retrieved July 25, 2014.
  20. ISBN 0415919363
    .
  21. ISBN 0231138849
    .
  22. ^ "The President's National Medal of Science: Recipient Details, Mildred Cohn". The National Science Foundation.
  23. ^ "ASBMB". ASBMB. Retrieved 2018-12-20.
  24. ^ "ASBMB Presidents :: 1978 – Mildred Cohn". Asbmb.org. Archived from the original on 2014-07-13. Retrieved 2018-12-20.
  25. ^ "Mildren Cohn (1913–2009) - American Chemical Society". Acs.org. Retrieved 2018-12-20.
  26. ^ "Mildren Cohn - National Women's Hall of Fame". National Women's Hall of Fame. Archived from the original on 2013-10-13.

External links

Library resources about
Mildred Cohn
By Mildred Cohn
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