Milk fever
Milk fever, postparturient hypocalcemia, or parturient paresis is a disease, primarily in
Clinical signs
The clinical signs of milk fever can be divided into three distinct stages:
Stage 1
Cows are mobile but show signs of hypersensitivity and excitability such as restlessness,[5] tremors, ear twitching, head bobbing, and mild ataxia.[6] If not treated, symptoms usually progress to stage 2.[7]
Stage 2
Cows can no longer stand and present in sternal recumbency.[6] Tachycardia, weakened heart contraction and peripheral pulses. Cows appear dull, have dry muzzles, cold extremities and a lower than normal body temperature. Smooth muscle paralysis can cause bloat, and the inability to urinate or defecate. Cows often tuck their heads into their flanks.[7]
Stage 3
Lateral recumbency,[8] muscle flaccidity,[5] unresponsiveness to stimuli, and loss of consciousness progressing to coma. Heart rate can approach 120 bpm, with peripheral pulses becoming undetectable. If untreated, progression will continue to death.[7]
Cause
During the dry period (late gestation, non-lactating), dairy cattle have relatively low calcium requirements, with a need to replace approximately 30 g of calcium per day due to utilization for fetal growth and fecal and urinary losses. At parturition, the requirement for calcium is greatly increased due to initiation of lactation, when mammary drainage of calcium may exceed 50g per day.[4] Due to this large increase in demand for calcium, most cows will experience some degree of hypocalcemia for a short period following parturition as the metabolism adjusts to the increased demand. When the mammary drain of plasma calcium causes hypocalcemia severe enough to compromise neuromuscular function, the cow is considered to have clinical milk fever.[3]
Mechanism
In normal calcium regulation, a decrease in plasma calcium levels causes the
It has been found that tissue is less responsive to parathyroid hormone prepartum, compared to postpartum. It is believed that hypocalcemia causing milk fever is due to a lower level of responsiveness of the cow's tissues to circulating parathyroid hormone.[3]
The resultant decreased plasma calcium causes hyperexcitability of the nervous system and weakened muscle contractions, which result in both tetany and paresis.[7]
Prevention
Diet
Proper dietary management will prevent most cases of milk fever. This generally involves close attention to mineral and fiber levels in the diet prior to calving, as well as improving cow comfort to eliminate other problems that may interfere with appetite (and so trigger hypocalcemia). General advice is to restrict calcium intake before calving, as this leads to the parathyroid gland stimulating the release of calcium from bones.[9]
Calcium salts
A synthetic analogue of
Oral administration of a dose of a
containing a much higher concentration of calcium than the injectable solutions can also be given so long as the cow is standing or sitting up. If the cow is lying 'flat out' then immediate intravenous therapy is required to avoid death.Treatment
Treatment generally involves calcium injection by intravenous, intramuscular or subcutaneous routes. Before calcium injection was employed, treatment comprised inflation of the udder using a pneumatic pump. Inflation of the udder worked because the increased pressure created in the udder pushed the calcium in the udder back into the bloodstream of the cow.[11]
Intravenous calcium, though indicated in many cases, is potentially fatal through "heart blockade", or transient high calcium levels stopping the heart, so should be administered with care. Cows are to be fed
Prognosis
The prognosis is generally good, even in advanced cases. However, some cows can relapse the following day,[11] and even a third time the day after.[12] Without treatment, between 60% and 80% of cows usually die,[13][14] although death rates as high as 90% have been recorded.[5]
History
It is thought that milk fever has existed for a very long time in dairy cattle.[15] The first reports in veterinary literature can be traced to around 1793.[13]
Early theories
Early treatments involved
Potassium iodide
In the late 1800s, Jurgens Schmidt proposed the use of an infused solution of potassium iodide for treatment.[15] A follow-up study of this treatment by Danish veterinarians showed that 90% of cows recovered after use of the treatment,[15] compared with only 20-40% survival without.[13][14] A study in Iowa showed that 76.5% of cows recovered after use of the treatment.[15] However, the premise of the Schmidt treatment was misleading, as later veterinarians used water alone to the same success rate.[13]
Udder inflation
In 1901, Anderson and Evers trialled a treatment of udder inflation with air, which reduced mortality rates to just 1%.[13][16] although with the added complication of mastitis.[16] Although this was an effective treatment (and is still used as a backup today),[11] it was not understood at the time why it worked, and remains the source of some debate. Some scientists believed that udder inflation could cause stimulation that then prevents calcium loss.[17] Other scientists suggested that udder inflation prevented milk secretion, reducing calcium loss overall.[18][19] This may prevent calcium being taken from the blood plasma.[18]
Later theories
The true cause of milk fever was first suggested by Prof John Russell Greig and Henry Dryerre in March 1925,[13] at the Moredun Research Institute in Scotland.[20] This idea was later confirmed experimentally by Little and Wright in May 1925.[13] By 1933, Pulles began treatments with magnesium chloride and calcium chloride, which is the basis for modern pharmaceutical treatments.[9]
References
- ^ "Parturient Paresis in Cows - Metabolic Disorders". Veterinary Manual. Retrieved 2020-10-10.
- ^ "Parturient Paresis in Sheep and Goats - Metabolic Disorders". Veterinary Manual. Retrieved 2020-10-10.
- ^ PMID 9241589.
- ^ PMID 18329301.
- ^ a b c "Parturient paresis | animal disease". Encyclopedia Britannica. Retrieved 2020-10-11.
- ^ a b "Parturient Paresis - an overview | ScienceDirect Topics". www.sciencedirect.com. Retrieved 2020-10-11.
- ^ a b c d "Parturient Paresis in Cows: Disorders of Calcium Metabolism: Merck Veterinary Manual". www.merckvetmanual.com. Retrieved 2015-11-06.
- PMID 3264754.
- ^ S2CID 23593159.
- PMID 4736359.
- ^
- ^ Lucien Mahin (1977–2008), Observations on diseases of cattle in Morocco (unpublished data)
- ^ ISSN 0022-0302.
- ^ PMID 9241589.
- ^ S2CID 84618576.
- ^ .
- PMID 17422555.
- ^ S2CID 88312791.
- ^ Garrison, E. R. ; Turner, C. W. (1936). "CAB Direct". www.cabdirect.org. Retrieved 2020-10-10.
{{cite web}}
: CS1 maint: multiple names: authors list (link) - ^ "Phone call reveals links to Moredun's past". Moredun Magazine. No. 6. 2013. p. 1. Archived from the original on 21 August 2016.
External links
- Prevention of Milk Fever, University of Kentucky
- Parturient Paresis in Cows (Milk fever, Hypocalcemia), The Merck Veterinary Manual