Miodrag Radulovacki

Source: Wikipedia, the free encyclopedia.
Miodrag Radulovacki
UCLA – Brain Research Institute, 1964-1965
University of Khartoum, Sudan, 1967-1970
College of Medicine at the University of Illinois at Chicago
(UIC), 1970 - 2014

Miodrag (Misha) Radulovacki (

Serbian American scientist and inventor. He was Professor of Pharmacology in the College of Medicine at the University of Illinois at Chicago (UIC),[1] Radulovacki's research accomplishments include: (1) the Adenosine Sleep Theory,[2] and (2) pioneering pharmacological studies for the treatment of sleep apnea,[3] together with research collaborator, David W. Carley,[4] (Professor of Medicine at the UIC). Radulovacki and Carley invented several drug therapies for the treatment of sleep apnea which have been patented by the UIC. The UIC recognized them as the 2010 "Inventors of the Year."[5][6] Radulovacki published more than 170 scientific papers.[7] Radulovacki was also a Foreign Member of the Serbian Academy of Sciences and Arts.[8]

Early life

Miodrag Radulovacki was born on April 28, 1933, in

teachers. At the beginning of World War II, Radulovacki's father was drafted into the Yugoslav Army and was later taken prisoner by the invading Germans.[citation needed
]

In 1943, Radulovacki moved to

School of Medicine.[9][10]

Education and scientific career

Radulovacki graduated from the University of Belgrade School of Medicine in 1959.

PhD in Neurophysiology.[12][13] The topic of his PhD thesis was: "Sleep in Split-Brain Cats," partly done at the Brain Research Institute at UCLA.[citation needed
]

Radulovacki spent 18 months at the

brain hemispheres, indicating the importance of the brainstem in sleep regulation.[11][16]

In 1966, Radulovacki accepted a teaching position with the

Monoamine Theory of Sleep,[18] with serotonin as the sleep inducing agent, was dominant at the time. From 1970 to 1984, at the University of Illinois, Radulovacki published a series of papers dealing with the role of monoamines in sleep.[7]

In 1970, Radulovacki was recruited by Klaus Unna[19] to join the Department of Pharmacology in the College of Medicine at the University of Illinois at Chicago as an Assistant Professor.[11] Radulovacki published more than 170 scientific papers during his career at the UIC.[7]

Scientific achievements

Adenosine Sleep Theory

In 1984, Radulovacki postulated the Adenosine Sleep Theory, (JPET, 228: 268-274, 1984).

micromolar concentrations with the blockade of adenosine receptors
.

Radulovacki reasoned that if the blocking of adenosine receptors produces excitation, then perhaps stimulation of the same receptors could induce sleep.

behavioral sleep. The explanation of adenosine's hypnotic effect was through its interaction with serotonin
, widely believed to be a sleep inducing agent. However, since there was no suggestion how this adenosine-serotonin link was achieved, experiments highlighting the potential role of adenosine in sleep had largely been forgotten.

Research collaboration with David W. Carley

In 1993, Radulovacki started a collaboration with David W. Carley, a Professor of

experimental model of sleep apnea in rats, initially testing the effects of adenosine compounds.[27] Eventually, they obtained positive results using serotonin and other compounds. As a result, the UIC patented their discoveries, obtaining numerous US and international patents.[28]

Patents for sleep and sleep-related disorders include:

  1. "Hypnotic Composition and Method of Inducing Sleep"; Inventor: Miodrag Radulovacki, US Patent 4537907, August 27, 1985. (This patent was issued to UIC before Radulovacki started his collaboration with Carley in 1993).[29]
  2. "Pharmacological Treatment for Sleep Apnea"; Inventors: Miodrag Radulovacki and David W. Carley, US Patent 6,331,536 B1, December 18, 2001.[30]
  3. "Neuropharmacological Treatments of Sleep-Related Breathing Disorders"; Inventors: Miodrag Radulovacki and David W. Carley, US Patent 6,555,564 B1, April 29, 2003.[31]
  4. "Pharmacological Treatment for Sleep Apnea"; Inventors: Miodrag Radulovacki and David W. Carley, US Patent 6,727,242 B2, April 27, 2004.[32]
  5. "Neuropharmacological Treatment of Sleep-Related Breathing Disorders"; Inventors: Miodrag Radulovacki and David W. Carley, US Patent 6,974,814 B2, December 13, 2005.[33]
  6. "Pharmacological Treatment for Sleep Apnea"; Inventors: Miodrag Radulovacki and David W. Carley, US Patent 7,160,898 B2, January 9, 2007.[34]
  7. "Method for Treating Sleep Apnea"; Inventors: David W. Carley and Miodrag Radulovacki, US Patent 7,705,039 B2, April 27, 2010.[35]
  8. "Methods for treating sleep disorders by cholecystokinin (CCK) receptor B antagonists": Inventors: David W. Carley and Miodrag Radulovacki, US Patent 8,053,413 B2, Nov. 8, 2011.[36]
  9. "Pharmacological treatments for sleep disorders (apnoe) with prostanoid receptor antagonists", Inventors: David W. Carley and Miodrag Radulovacki, US Patent 8,076,315, Dec. 13, 2011.[37]

Inventor of the Year 2010

Radulovacki was named the 2010 Inventor of the Year at the University of Illinois, alongside Carley.[5] Radulovacki and Carley were honored by the University of Illinois for producing a dozen potential treatments for sleep apnea, many of which are now under consideration for commercial development.[38] Their results have culminated in an IllinoisVentures-supported start-up company, Pier Pharmaceuticals, that focuses on the treatment of obstructive sleep apnea.[39]

Membership in the Serbian Academy of Sciences and Arts

In October 2003, the Serbian Academy of Sciences and Arts in Belgrade elected Radulovacki as one of its Foreign Members for his significant scientific research contributions in the fields of Neuropharmacology, sleep disorders and sleep-related breathing disorders.[8]

Yugoslav Student Summer Program

In 1990, Radulovacki initiated the Yugoslav Student Summer Program at the

Champaign-Urbana (UIUC) after the creation of International Linkage Agreements between the UIC and the Universities of Belgrade and Novi Sad in Yugoslavia.[40] The Yugoslav Student Summer Program lasted for 12 years and had 304 participants.[41]

Philanthropy

In 2005, Radulovacki established the Miodrag Radulovacki Family Prize for Excellence in Basic Sciences at the University of Illinois College of Medicine at Chicago.[11] The purpose of the prize, given annually, is to honor a fourth year Medical student who displays a high degree of intellectual integrity and who has demonstrated strong academic achievement. The prize consists of a plaque and a check for $1,000.

Radulovacki made numerous contributions to his home town of Sremski Karlovci.

Personal life

Radulovacki lived in Chicago. He was a cross-country skier.[12] He participated in several Birkebeiner-Kortelopet cross-country ski marathons in Cable-Hayward, Wisconsin.[citation needed] Radulovacki died on May 27, 2014, in Belgrade, Serbia, while on two-week trip to promote his philanthropic projects. He is survived by two sons (Brad Radulovacki and Branko Radulovacki) and four grandchildren (Grant, Katie, Reid and Ryan).[46][47]

Selected publications

  1. Radulovacki, M (1973). "5-Hydroxyindoleacetic acid in cerebrospinal fluid: Measurements in wakefulness, slow-wave and paradoxical sleep". Brain Research. 50 (2): 484–8.
    PMID 4705518
    .
  2. Kovacević, R; Radulovacki, M (1976). "Monoamine changes in the brain of cats during slow-wave sleep". Science. 193 (4257): 1025–7.
    PMID 948760
    .
  3. Radulovacki, M; Buckingham, RL; Chen, EH; Kovacević, R (1977). "Similar effects of tryptophan and sleep on cisternal cerebrospinal fluid 5-hydroxyindoleacetic and homovanillic acids in cats". Brain Research. 129 (2): 371–4.
    S2CID 39245160
    .
  4. Radulovacki, M; Walovitch, R; Yanik, G (1980). "Caffeine produces REM sleep rebound in rats". Brain Research. 201 (2): 497–500.
    S2CID 8131652
    .
  5. Radulovacki, M; Zak, R (1981). "Amphetamine abolishes REM sleep rebound in rats: Effect of single injection". Brain Research. 217 (2): 420–4.
    S2CID 27030990
    .
  6. Radulovacki, M; Virus, RM; Djuricic-Nedelson, M; Green, RD (1984). "Adenosine analogs and sleep in rats". The Journal of Pharmacology and Experimental Therapeutics. 228 (2): 268–74.
    PMID 6694111
    .
  7. Radulovacki, M (1985). "Role of adenosine in sleep in rats". Reviews in Clinical & Basic Pharmacology. 5 (3–4): 327–39.
    PMID 3916307
    .
  8. Radulovacki, M (2005). "Adenosine sleep theory: How I postulated it". Neurological Research. 27 (2): 137–8.
    S2CID 37526153
    .
  9. Radulovacki, M; Trbovic, SM; Carley, DW (1998). "Serotonin 5-HT3-receptor antagonist GR 38032F suppresses sleep apneas in rats". Sleep. 21 (2): 131–6.
    PMID 9542796
    .
  10. Carley, DW; Radulovacki, M (1999). "Role of peripheral serotonin in the regulation of central sleep apneas in rats". Chest. 115 (5): 1397–401.
    PMID 10334159
    .
  11. Prasad, B; Radulovacki, M; Olopade, C; Herdegen, JJ; Logan, T; Carley, DW (2010). "Prospective trial of efficacy and safety of ondansetron and fluoxetine in patients with obstructive sleep apnea syndrome". Sleep. 33 (7): 982–9.
    PMID 20614859
    .

Related publications

References

  1. ^ "Faculty Research: Miodrag Radulovacki, MD, PhD Professor of Pharmacology and Medicine-Respiratory and Critical Care". University of Illinois College of Medicine.
  2. S2CID 37526153
    .
  3. Science Daily
    .
  4. University of Illinois at Chicago
    .
  5. ^ a b "Meet the winners of the UIC 2010 Inventor of the Year Award". UIC News. February 10, 2011. Archived from the original on 2011-05-07.
  6. ^ "UIC OTM Announces 2010 Inventor of the Year". UIC Office of Technology Management. February 8, 2011. Archived from the original on October 21, 2013.
  7. ^ a b c "Miodrag Radulovacki partial list of research publications, UIC Department of Pharmacology". PubMed.
  8. ^ a b "Miodrag Radulovacki, MD, PhD, Foreign Member". Serbian Academy of Sciences and Arts.
  9. ^
    YouTube
  10. ^
    YouTube
  11. ^ a b c d e Summary biography of Miodrag Radulovacki, Illinois Medicine Fiscal Year 2009 Report - Honor Roll of Donors, page 27 (Prizing Discovery)
  12. ^ a b c University of Illinois, Dr. Miodrag Radulovacki profile
  13. ^ a b University of Illinois Department of Pharmacology Faculty Profiles
  14. ^ UCLA Brain Research Institute
  15. ^ Hanley, John. "In Memoriam: William Ross Adey, M.D., Professor of Anatomy and Physiology, Los Angeles, 1922–2004". Archived from the original on 2005-09-29.
  16. ISBN 9780080861524
    .
  17. PMID 1197913
    .
  18. ^ Jouvet, Michel (March 22, 1993). "From Amines to Sleep" (PDF). Current Contents: 8.
  19. ^ Baumann, Edward (July 4, 1987). "Klaus Unna, 79, U. Of I. Pharmacology Professor". Chicago Tribune.
  20. PMID 6694111
    .
  21. PMID 6265942
    .
  22. ISBN 9067640980
    .
  23. PMID 93018
    .
  24. S2CID 46663273
    .
  25. University of Illinois at Chicago College of Medicine
    .
  26. PMID 17310863
    .
  27. ISBN 9780824745684
    .
  28. ^ Patents by the UIC, Pharmacological Treatments for Sleep Disorders.
  29. ^ "Hypnotic Composition and Method of Inducing Sleep"; Inventor: Miodrag Radulovacki.
  30. ^ "Pharmacological Treatment for Sleep Apnea"; Inventors: Miodrag Radulovacki and David W. Carley. Archived 2012-09-06 at archive.today
  31. ^ "Neuropharmacological Treatments of Sleep-Related Breathing Disorders"; Inventors: Miodrag Radulovacki and David W. Carley. Archived 2012-09-08 at archive.today
  32. ^ "Pharmacological Treatment for Sleep Apnea"; Inventors: Miodrag Radulovacki and David W. Carley.
  33. ^ "Neuropharmacological Treatment of Sleep-Related Breathing Disorders"; Inventors: Miodrag Radulovacki and David W. Carley.
  34. ^ "Pharmacological Treatment for Sleep Apnea"; Inventors: Miodrag Radulovacki and David W. Carley.
  35. ^ "Method for Treating Sleep Apnea"; Inventors: David W. Carley and Miodrag Radulovacki.
  36. ^ "Methods for treating sleep disorders by cholecystokinin (CCK) receptor B antagonists": Inventors: David W. Carley and Miodrag Radulovacki.
  37. ^ "Pharmacological treatments for sleep disorders (apnoe) with prostanoid receptor antagonists": Inventors: David W. Carley and Miodrag Radulovacki. Archived 2012-09-06 at archive.today
  38. ^ UIC OTM Announces 2010 Inventor of the Year Archived 2012-04-26 at the Wayback Machine
  39. ^ Pier Pharmaceuticals web site Home Page Archived 2011-12-28 at the Wayback Machine
  40. ^ The Yugoslav Student Summer Program at the University of Illinois
  41. ^ Yugoslav Student Summer Program, Participants
  42. ^ Ecological Center Karlovci
  43. ^ Picture of renovated baroque facade of the Ecological Center in Karlovci, Ecological Center Karlovci web site Archived 2012-04-26 at the Wayback Machine
  44. YouTube
  45. ^ Ecological Center Karlovci newsletter and update on the new construction project
  46. ^ "Miodrag Radulovacki Obituary". legacy.suntimes.com. Retrieved 2023-07-05.
  47. ^ "Blic Online | Preminuo akademik Miodrag Radulovački". Blic.rs. 6 February 2014. Retrieved 2014-06-03.
Retrieved from "https://en.wikipedia.org/w/index.php?title=Miodrag_Radulovacki&oldid=1165328877"