Mithridatism

Source: Wikipedia, the free encyclopedia.

Mithridatism is the practice of protecting oneself against a

immunity
.

Background

Hellenistic kingdom, 281 BC–62 AD) until a male heir came of age. Mithridates was in competition with his brother for the throne and his mother began to favor his brother.[2]: 68  Supposedly, during his youth, he began to suspect plots against him at his own mother's orders and was aware of her possible connection with his father's death. He then began to notice pains in his stomach during his meals and suspected his mother had ordered small amounts of poison to be added to his food to slowly kill him off. With other assassination attempts, he fled into the wild.[2]
: 69 

While in the wild, it is said that he began ingesting non-lethal amounts of poisons and mixing many into a universal remedy to make him immune to all known poisons.[3]

After Mithridates' death, many Roman physicians claimed to possess and improve the formula. In keeping with most medical practices of his era, Mithridates' anti-poison routines included a religious component, supervised by the Agari, a group of

shamans who never left him.[4]

It has been suggested that Russian mystic

Rasputin's survival of a poisoning attempt was due to mithridatism, but this has not been proven.[5]

Indian epics talk about this practice as well. It has been said that, during the rule of the king

vishakanyas
(visha 'poison' + kanya 'maiden'). It was believed that making love with vishakanyas could result in the death of their partners, hence they were employed to kill enemies.

The emperor

Jain texts, Chandragupta's Guru and advisor Chanakya used to feed the emperor with small doses of poison to build his immunity against possible poisoning attempts by the enemies.[6] One day, Chandragupta, not knowing about the poison, shared his food with his pregnant wife, Queen Durdhara, who was seven days away from delivery. The queen, not immune to the poison, collapsed and died within a few minutes. Chanakya entered the room the very time she collapsed, and in order to save the child in the womb, he immediately cut open the dead queen's belly and took the baby out, by that time a drop of poison had already reached the baby and touched its head due to which the child got a permanent blueish spot (a "bindu") on his forehead. Thus, the newborn was named "Bindusara".[7]

In practice

Mithridatism is not effective against all types of poison. Immunity is generally only possible with biologically complex types which the immune system can respond to. Depending on the toxin, the practice can lead to the lethal accumulation of a poison in the body. Results depend on how each poison is processed by the body, i.e. on how the toxic compound is metabolized or passed out of the body.[8]

However, in some cases, it is possible to build up a metabolic tolerance against specific non-biological poisons. This involves conditioning the liver to produce more of the particular enzymes that metabolize these poisons. For example, heavy drinkers develop a tolerance to the effects of alcohol.[9] However, metabolic tolerance can also lead to accumulation of the less toxic metabolized compound which can slowly damage the liver. With alcohol this generally leads to conditions such as alcoholic fatty liver disease.[10]

Metabolic tolerance is not effective on all types of non-biological poisons. Exposure to certain toxic substances, such as hydrofluoric acid and heavy metals, is either lethal or has little to no effect. A minor exception is cyanide, which can be metabolized by the liver. The enzyme rhodanese converts the cyanide into the much less toxic thiocyanate.[11] This process allows humans to ingest small amounts of cyanide in food like apple seeds and survive small amounts of cyanide gas from fires and cigarettes. However, one cannot effectively condition the liver against cyanide, unlike alcohol. Relatively larger amounts of cyanide are still highly lethal because, while the body can produce more rhodanese, the process also requires large amounts of sulfur-containing substrates.[12]

In literature

Mithridatism has been used as a plot device in fiction and on-screen; including the Indian fantasy series

Curtain, the manhwa Roxana, William Goldman's The Princess Bride (as well as its film adaptation), and the American historical series The Borgias
.

In Michael Curtis Ford's historical novel The Last King, on the life and conquests of Mithridates VI, the technique is used by Mithridates.

A. E. Housman's "Terence, this is stupid stuff" (originally published in A Shropshire Lad) invokes mithridatism as a metaphor for the benefit that serious poetry brings to the reader. The final section is a poetic rendition of the Mithridates legend.

See also

References

  1. ISBN 9781845110024. Archived from the original
    on 30 Dec 2005.
  2. ^ a b Mayor, Adrienne (2011). The Poison King: the life and legend of Mithradates, Rome's deadliest enemy. Princeton University Press.
  3. ^ McGing, B.C. (1986). The Foreign Policy of Mithridates VI Eupator, King of Pontus. Leiden: E.J. Brill. p. 43.
  4. ^ Mayor, Adrienne (2003). Greek Fire, Poison Arrows, and Scorpion Bombs: Biological and Chemical Warfare in the Ancient World. New York: Overlook Duckworth. p. 148.
  5. ^ Segen, J.C. (1992). The Dictionary of Modern Medicine.
  6. OCLC 559688590
    .
  7. .
  8. PMID 30450285.{{cite journal}}: CS1 maint: multiple names: authors list (link
    )
  9. ^ "Alcohol and Tolerance". National Institute on Alcohol Abuse and Alcoholism. Apr 1995.
  10. ^ "Fatty Liver Disease". US National Library of Medicine.
  11. ^ "The Facts About Cyanides". New York State: Department of Health. Apr 2006.
  12. ^ "Cyanide in Drinking-water" (PDF). World Health Organization. 2009.