Morquio syndrome

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Morquio syndrome
Other namesMucopolysaccharidosis IV, MPS IV, Morquio-Brailsford syndrome, or Morquio[1]
Patient with Morquio syndrome
SpecialtyEndocrinology Edit this on Wikidata
ComplicationsSkeletal abnormalities, hearing loss, pulmonary failure, heart disease
Usual onsetBirth; condition usually becomes apparent between ages 1 and 3
DurationLifelong
TypesType A and Type B
CausesInherited deficiency of enzymes
TreatmentElosulfase alfa (Vimizim) for Type A; no approved treatment for Type B
PrognosisReduced lifespan. Usually death occurs in 20s to 30s
Frequency1 in 200,000 to 1 in 300,000

Morquio syndrome, also known as

lysosomal storage disorder. The buildup of GAGs in different parts of the body causes symptoms in many different organ systems.[2]: 544  In the US, the incidence rate for Morquio syndrome is estimated at between 1 in 200,000 and 1 in 300,000 live births.[1][3]

Signs and symptoms

Corneal clouding in a 30-year-old male with MPS VI. Morquio syndrome and other MPS disorders may also present with corneal clouding.

Patients with Morquio syndrome appear healthy at birth. Types A and B have similar presentations, but Type B generally has milder symptoms. The age of onset is usually between 1 and 3 years of age. Morquio syndrome causes progressive changes to the skeleton of the ribs and chest, which may lead to neurological complications such as nerve compression. Patients may also have hearing loss and clouded corneas. Intelligence is usually normal unless a patient has untreated hydrocephalus.[citation needed]

Physical growth slows and often stops around age 8. Skeletal abnormalities include a bell-shaped chest, a flattening or curvature of the spine, shortened long bones, and dysplasia of the hips, knees, ankles, and wrists. The bones that stabilize the connection between the head and neck can be malformed (odontoid hypoplasia); in these cases, a surgical procedure called spinal cervical bone fusion can be lifesaving. Restricted breathing, joint stiffness, and heart disease are also common. Children with the more severe form of MPS IV may not live beyond their twenties or thirties.[citation needed]

Some additional signs and symptoms of Morquio syndrome include a short stature,

knock-knees, pectus carinatum, misshapen limbs, unstable vertebrae, cord compression, hepatomegaly, hearing problems, vision problems, and heart problems.[4]

Cause

Morquio syndrome is inherited from an

autosomal recessive inherited gene. Every person has two copies of the genes needed to break down keratan sulfate, but only one healthy copy is needed. Both parents pass down one defective copy to their child, resulting in a child with no functional copies of the gene. As such, the body is incapable breaking down keratan sulfate for disposal. The incompletely broken down GAGs remain stored in cells in the body, causing progressive damage. Babies may show little sign of the disease, but as more and more cells become damaged, symptoms start to appear.[5]

Diagnosis

Classification

This syndrome has two forms, A and B, referred to as Morquio A and Morquio B syndrome or MPS IVA and MPS IVB. The two forms are distinguished by the gene product involved; Type A involves a malfunction in the

GALNS gene, while Type B involves a malfunction of the GLB1 gene.[citation needed
]

Genetics of MPS IV
Morquio syndrome type Gene Missing enzyme Chromosomal region
Type A
GALNS
Galactosamine-6 sulfatase 16q24
Type B GLB1
Beta-galactosidase
3p22

Treatment

The treatment for Morquio syndrome consists of

US Food and Drug Administration approved the drug elosulfase alfa (Vimizim) for treating Type A. Currently, there is no treatment for Type B.[5]

Prognosis

The lifespan of patients with Morquio syndrome is variable and depends on the subtype. Type A is generally severe, with a life expectancy in the 20s to 30s.[6] In 2016, a man with Morquio syndrome died at the age of 81.[7]

One study found that the mean life expectancy for patients in the

heart attack (4%). Life expectancy has been increasing since the 1980s. The average age at death due to respiratory failure improved from 17.42 years old in the 1980s to 30.74 years old in the 2000s.[8]

History

The condition was first described, simultaneously and independently, in 1929, by Luis Morquio (1867–1935),[9] a prominent Uruguayan physician who discovered it in Montevideo, and James Frederick Brailsford (1888–1961), an English radiologist in Birmingham, England.[10][11] They both recognized the occurrence of corneal clouding, aortic valve disease, and urinary excretion of keratan sulfate. Morquio observed the disorder in four siblings in a family of Swedish descent and reported his observations in French.{{<[12]}}

See also

References

  1. ^ a b "MPS IV (Morquio syndrome)". MPSSociety.org. National MPS Society. Archived from the original on 21 August 2017. Retrieved 14 January 2015.
  2. .
  3. .
  4. ^ "Morquio Syndrome". Nemours KidsHealth. Retrieved 14 February 2023.
  5. ^ a b "MPS IV (Morquio Syndrome)". Canadian MPS Society. Retrieved 14 June 2019.
  6. ^ "Mucopolysaccharidoses Fact Sheet". National Institute of Neurological Disorders and Stroke. 13 May 2019. Retrieved 14 June 2019.
  7. ^ Blacketer, Rosie (23 September 2016). "Kenneth Dean Martin". Osage County Herald-Chronicle. Retrieved 14 June 2019.
  8. PMID 24718838
    .
  9. .
  10. Who Named It?
  11. .
  12. ^ ref>citation needed|date=November 2020</https://www.whonamedit.com/synd.cfm/2108.html>

External links