Multidrug resistance-associated protein 2

Source: Wikipedia, the free encyclopedia.
ABCC2
Identifiers
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Ensembl
UniProt
RefSeq (mRNA)

NM_000392

NM_013806

RefSeq (protein)

NP_000383

NP_038834

Location (UCSC)Chr 10: 99.78 – 99.85 MbChr 19: 43.77 – 43.83 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Multidrug resistance-associated protein 2 (MRP2) also called canalicular multispecific organic anion transporter 1 (cMOAT) or ATP-binding cassette sub-family C member 2 (ABCC2) is a protein that in humans is encoded by the ABCC2 gene.[5][6][7]

Function

MRP2 is a member of the superfamily of

multi-drug resistance. This protein is expressed in the canalicular (apical) part of the hepatocyte and functions in biliary transport. Substrates include anticancer drugs such as vinblastine
; therefore, this protein appears to contribute to drug resistance in mammalian cells.

MRP2 is also expressed in the

endothelial cells where they are involved in the excretion of small organic anions.[8]

MRP2 inhibitors

Drug Class Indications Source Structure
probenecid uricosuric gout
hyperuricemia
[9]
furosemide loop diuretic heart failure
edema
[9]
ritonavir protease inhibitor
antiretroviral
[10]
saquinavir protease inhibitor
antiretroviral
[11]
lamivudine
Nucleoside analog
antiviral [12]
abacavir
Nucleoside analog
antiretroviral
[12]
emtricitabine
Nucleoside analog
antiviral [12]
efavirenz
NNRTI
antiretroviral
[12]
delavirdine
NNRTI
antiretroviral
[12]
nevirapine
NNRTI
antiretroviral
[12]
cidofovir nucleoside phosphonate antiviral [13]
adefovir nucleoside phosphonate antiviral [11]
tenofovir
nucleoside phosphonate antiviral [12]

Clinical significance

Dubin–Johnson syndrome

Several different mutations in this gene have been observed in patients with Dubin–Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia.[7][14]

Iatrogenic Fanconi syndrome

Many negatively charged metabolic waste products are eliminated from the body by the kidneys. These

molecules are transported into the lumen of the tubule by the MRP2 transporter. Many drugs are eliminated from the body by this mechanism. Some of these drugs pass through the MRP2 transporter slowly. This may cause a buildup of organic anions in the cytoplasm
of the cells.

Drugs that inhibit the MRP2 transporter can cause a buildup of organic anions inside renal proximal tubule cells. If some of these organic anions inhibit mitochondrial DNA synthesis, it may cause

are also nucleoside phosphonates that inhibit MRP2 and have been associated with Fanconi syndrome.

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles. [§ 1]

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IrinotecanPathway_WP46359go to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to article
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IrinotecanPathway_WP46359go to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to articlego to article
|alt=Irinotecan Pathway edit]]
Irinotecan Pathway edit
  1. ^ The interactive pathway map can be edited at WikiPathways: "IrinotecanPathway_WP229".

See also

  • ATP-binding cassette transporter

References

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.