Multiple carboxylase deficiency
| Multiple carboxylase deficiency | |
|---|---|
| Specialty | Medical genetics, endocrinology  |
Multiple carboxylase deficiency is a form of metabolic disorder involving failures of carboxylation enzymes.
The deficiency can be in biotinidase or holocarboxylase synthetase.[1]
These conditions respond to biotin.[2]
Forms include:
- Holocarboxylase synthetase deficiency - neonatal;
- Biotinidase deficiency - late onset;
If left untreated, the symptoms can include feeding problems,
baldness, failure to thrive, seizure, coma, developmental delay, foul smelling urine, lactic acidosis, and high levels of ketones and ammonia
in the blood.
References
- ^ "Multiple Carboxylase Deficiency". Archived from the original on 2008-08-28.
- ^ "Definition: multiple carboxylase deficiency from Online Medical Dictionary".
External links
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