Myocyte-specific enhancer factor 2A
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Myocyte-specific enhancer factor 2A is a
autosomal dominant form of coronary artery disease and myocardial infarction
.
Function
The process of differentiation from mesodermal precursor cells to myoblasts has led to the discovery of a variety of tissue-specific factors that regulate muscle gene expression. The myogenic basic helix-loop-helix proteins, including myoD (MIM 159970), myogenin (MIM 159980), MYF5 (MIM 159990), and MRF4 (MIM 159991) are 1 class of identified factors. A second family of DNA binding regulatory proteins is the myocyte-specific enhancer factor-2 (MEF2) family. Each of these proteins binds to the MEF2 target DNA sequence present in the regulatory regions of many, if not all, muscle-specific genes. The MEF2 genes are members of the MADS gene family (named for the yeast mating type-specific transcription factor MCM1, the plant homeotic genes 'agamous' and 'deficiens' and the human serum response factor SRF (MIM 600589)), a family that also includes several homeotic genes and other transcription factors, all of which share a conserved DNA-binding domain.[supplied by OMIM][6]
Interactions
Myocyte-specific enhancer factor 2A has been shown to
interact
with:
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000068305 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030557 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- PMID 1516833.
- ^ a b "Entrez Gene: MEF2A MADS box transcription enhancer factor 2, polypeptide A (myocyte enhancer factor 2A)".
- PMID 8662987.
- ^ PMID 12371907.
- ^ PMID 10487761.
- ^ PMID 10748098.
- PMID 9858528.
- PMID 10330143.
- PMID 8798771.
- PMID 11160896.
Further reading
- Wang Q (2005). "Advances in the Genetic Basis of Coronary Artery Disease". Current Atherosclerosis Reports. 7 (3): 235–41. PMID 15811259.
- Wang Q (2005). "Molecular genetics of coronary artery disease". Curr. Opin. Cardiol. 20 (3): 182–8. PMID 15861005.
- Funk WD, Wright WE (1992). "Cyclic amplification and selection of targets for multicomponent complexes: myogenin interacts with factors recognizing binding sites for basic helix-loop-helix, nuclear factor 1, myocyte-specific enhancer-binding factor 2, and COMP1 factor". Proc. Natl. Acad. Sci. U.S.A. 89 (20): 9484–8. PMID 1329097.
- Pollock R, Treisman R (1992). "Human SRF-related proteins: DNA-binding properties and potential regulatory targets". Genes Dev. 5 (12A): 2327–41. PMID 1748287.
- Molkentin JD, Black BL, Martin JF, Olson EN (1996). "Cooperative activation of muscle gene expression by MEF2 and myogenic bHLH proteins". Cell. 83 (7): 1125–36. PMID 8548800.
- Hobson GM, Krahe R, Garcia E, Siciliano MJ, Funanage VL (1996). "Regional chromosomal assignments for four members of the MADS domain transcription enhancer factor 2 (MEF2) gene family to human chromosomes 15q26, 19p12, 5q14, and 1q12-q23". Genomics. 29 (3): 704–11. PMID 8575763.
- Mao Z, Nadal-Ginard B (1996). "Functional and physical interactions between mammalian achaete-scute homolog 1 and myocyte enhancer factor 2A". J. Biol. Chem. 271 (24): 14371–5. PMID 8662987.
- Suzuki E, Lowry J, Sonoda G, Testa JR, Walsh K (1996). "Structures and chromosome locations of the human MEF2A gene and a pseudogene MEF2AP". Cytogenet. Cell Genet. 73 (3): 244–9. PMID 8697817.
- Ornatsky OI, McDermott JC (1996). "MEF2 protein expression, DNA binding specificity and complex composition, and transcriptional activity in muscle and non-muscle cells". J. Biol. Chem. 271 (40): 24927–33. PMID 8798771.
- Black BL, Molkentin JD, Olson EN (1998). "Multiple Roles for the MyoD Basic Region in Transmission of Transcriptional Activation Signals and Interaction with MEF2". Mol. Cell. Biol. 18 (1): 69–77. PMID 9418854.
- Yang CC, Ornatsky OI, McDermott JC, Cruz TF, Prody CA (1998). "Interaction of myocyte enhancer factor 2 (MEF2) with a mitogen-activated protein kinase, ERK5/BMK1". Nucleic Acids Res. 26 (20): 4771–7. PMID 9753748.
- Zhao M, New L, Kravchenko VV, Kato Y, Gram H, di Padova F, Olson EN, Ulevitch RJ, Han J (1999). "Regulation of the MEF2 Family of Transcription Factors by p38". Mol. Cell. Biol. 19 (1): 21–30. PMID 9858528.
- Yang SH, Galanis A, Sharrocks AD (1999). "Targeting of p38 Mitogen-Activated Protein Kinases to MEF2 Transcription Factors". Mol. Cell. Biol. 19 (6): 4028–38. PMID 10330143.
- Iida K, Hidaka K, Takeuchi M, Nakayama M, Yutani C, Mukai T, Morisaki T (1999). "Expression of MEF2 genes during human cardiac development". Tohoku J. Exp. Med. 187 (1): 15–23. PMID 10458488.
- Miska EA, Karlsson C, Langley E, Nielsen SJ, Pines J, Kouzarides T (1999). "HDAC4 deacetylase associates with and represses the MEF2 transcription factor". EMBO J. 18 (18): 5099–107. PMID 10487761.
- Mao Z, Bonni A, Xia F, Nadal-Vicens M, Greenberg ME (1999). "Neuronal activity-dependent cell survival mediated by transcription factor MEF2". Science. 286 (5440): 785–90. PMID 10531066.
- Lu J, McKinsey TA, Nicol RL, Olson EN (2000). "Signal-dependent activation of the MEF2 transcription factor by dissociation from histone deacetylases". Proc. Natl. Acad. Sci. U.S.A. 97 (8): 4070–5. PMID 10737771.
- Lemercier C, Verdel A, Galloo B, Curtet S, Brocard MP, Khochbin S (2000). "mHDA1/HDAC5 histone deacetylase interacts with and represses MEF2A transcriptional activity" (PDF). J. Biol. Chem. 275 (20): 15594–9. S2CID 39220205.
- Youn HD, Grozinger CM, Liu JO (2000). "Calcium regulates transcriptional repression of myocyte enhancer factor 2 by histone deacetylase 4". J. Biol. Chem. 275 (29): 22563–7. PMID 10825153.
External links
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