N,α-Diethylphenethylamine

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N,alpha-Diethylphenylethylamine
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N,α-Diethylphenethylamine
Clinical data
Other namesN,α-Diethylphenylethylamine
N,α-Diethylbenzeneethanamine
2-Amino-N-ethyl-1-phenylbutane
2-Ethylamino-1-phenylbutane
Ethyl(1-phenylbutan-2-yl)amine
Legal status
Legal status
Identifiers
  • N-Ethyl-1-phenylbutan-2-amine
JSmol)
  • C(C)NC(CC1=CC=CC=C1)CC
  • InChI=1S/C12H19N/c1-3-12(13-4-2)10-11-8-6-5-7-9-11/h5-9,12-13H,3-4,10H2,1-2H3
  • Key:KHWYSUBVXWWBRB-UHFFFAOYSA-N

N,α-Diethylphenethylamine (N,α-DEPEA, 2-ethylamino-1-phenylbutane, EAPB) is a close

chemical analog of methamphetamine, which has been sold as a designer drug.[1][2][3] It was originally patented by Knoll Pharma as one of several analogs for pharmaceutical applications. In animal models these analogs showed properties of cognitive enhancement and increased pain tolerance.[4]
Nevertheless, this class of compounds was never developed into a medicine. N,α-DEPEA has not been studied in humans, but experts such as Pieter Cohen of Harvard Medical School expect it to be less potent than methamphetamine, but greater than ephedrine.[5]

Adulterant in nutritional supplements

In January 2013, the South Korean authorities reported seizing a large quantity of the pure material, predicting it would soon be found on the market.[6] Later in 2013, it was found as an adulterant in biologically significant amounts in the pre-workout supplements Craze (marketed by Driven Sports, Inc.) and Detonate (marketed by Gaspari Nutrition).[4][7] It was falsely claimed to be Dendrobium extract.[5][8][9]

See also

References

  1. PMID 26311473
    .
  2. PMID 24451085
    .
  3. ^ "2-Ethylamino-1-phenylbutane". Cayman Chemical. Retrieved 4 November 2015.
  4. ^
    S2CID 41372093
    .
  5. ^ a b "Craze manufacturer disputes NSF's discovery of drug tainting". Nutraingredients. October 17, 2013.
  6. S2CID 13523048
    .
  7. ^ "Popular sports supplements contain meth-like compound". USA Today. October 25, 2013.
  8. S2CID 42232885
    .
  9. ^ Warning issued over CRAZE sports supplement. New Zealand Herald, 13 November 2013
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