NFE2L3
| NFE2L3 | |||
|---|---|---|---|
| Identifiers | |||
Gene ontology | |||
| Molecular function |
| ||
| Cellular component | |||
| Biological process | |||
| Sources:Amigo / QuickGO | |||
Ensembl | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| UniProt | |||||||||
| RefSeq (mRNA) | |||||||||
| RefSeq (protein) | |||||||||
| Location (UCSC) | Chr 7: 26.15 – 26.19 Mb | Chr 6: 51.41 – 51.44 Mb | |||||||
| PubMed search | [3] | [4] | |||||||
| View/Edit Human | View/Edit Mouse |
Nuclear factor (erythroid 2)-like factor 3, also known as NFE2L3 or 'NRF3', is a transcription factor that in humans is encoded by the Nfe2l3 gene.[5][6]
Nrf3 is a basic leucine zipper (bZIP) transcription factor belonging to the Cap ‘n’ Collar (CNC) family of proteins.[7] In 1989, the first CNC transcription factor NFE2L2 was identified. Subsequently, several related proteins were identified, including NFE2L1 and NFE2L3, in different organisms such as humans, mice, and zebrafish.[8] These proteins are specifically encoded in the humans by Nfe2l1 and Nfe2l3 genes respectively.[9][10]
Gene
The Nfe2l3 gene was mapped to the chromosomal location 7p15-p14 by fluorescence in situ hybridization (FISH).[9] It covers 34.93 kB from base 26191830 to 26226754 on the direct DNA strand with an exon count of 4. The gene is found near the HOXA gene cluster, similar to the clustering of p45 NF-E2, NFE2L1, and NFE2L2 near HOXC, HOXB, and HOXD genes respectively.[7][9] This implies that all four genes were likely derived from a single ancestral gene which was duplicated alongside the ancestral HOX cluster, diverging to give rise to four closely related transcription factors.[9]
The human Nfe2l3 gene encodes a 694
Sub-cellular location
NRF3 is a
Protein expression levels
Function
The specific functions of the NRF3 protein are still unknown, but some putative functional properties have been inferred from those of
Associated diseases
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000050344 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029832 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: nuclear factor (erythroid-derived 2)-like 3".
- PMID 10037736.
- ^ PMID 3289117.
- PMID 15060151.
- ^ S2CID 25006101.
- PMID 8036168.
- PMID 22247257.
- PMID 28970512.
- PMID 15388789.
- PMID 21148084.
- PMID 21057541.
- PMID 9872330.
- PMID 9397686.
- PMID 16670065.
- PMID 11689285.
Further reading
- Davila S, Froeling FE, Tan A, Bonnard C, Boland GJ, Snippe H, Hibberd ML, Seielstad M (April 2010). "New genetic associations detected in a host response study to hepatitis B vaccine". Genes and Immunity. 11 (3): 232–8. PMID 20237496.
- Sankaranarayanan K, Jaiswal AK (December 2004). "Nrf3 negatively regulates antioxidant-response element-mediated expression and antioxidant induction of NAD(P)H:quinone oxidoreductase1 gene". The Journal of Biological Chemistry. 279 (49): 50810–7. PMID 15385560.
- Chénais B, Derjuga A, Massrieh W, Red-Horse K, Bellingard V, Fisher SJ, Blank V (January 2005). "Functional and placental expression analysis of the human NRF3 transcription factor". Molecular Endocrinology. 19 (1): 125–37. PMID 15388789.
- Nouhi Z, Chevillard G, Derjuga A, Blank V (November 2007). "Endoplasmic reticulum association and N-linked glycosylation of the human Nrf3 transcription factor". FEBS Letters. 581 (28): 5401–6. S2CID 2876177.
- Terui K, Takahashi Y, Kitazawa J, Toki T, Yokoyama M, Ito E (December 2000). "Expression of transcription factors during megakaryocytic differentiation of CD34+ cells from human cord blood induced by thrombopoietin". The Tohoku Journal of Experimental Medicine. 192 (4): 259–73. PMID 11286316.
- Sanger Centre, The; Washington University Genome Sequencing Cente, The (November 1998). "Toward a complete human genome sequence". Genome Research. 8 (11): 1097–108. PMID 9847074.
- Zhang Y, Kobayashi A, Yamamoto M, Hayes JD (January 2009). "The Nrf3 transcription factor is a membrane-bound glycoprotein targeted to the endoplasmic reticulum through its N-terminal homology box 1 sequence". The Journal of Biological Chemistry. 284 (5): 3195–210. PMID 19047052.
- Waku T, Kobayashi A (November 2021). "Pathophysiological Potentials of NRF3-Regulated Transcriptional Axes in Protein and Lipid Homeostasis". International Journal of Molecular Sciences. 22 (23): 12686. PMID 34884489.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.