NFIL3
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| Location (UCSC) | Chr 9: 91.41 – 91.42 Mb | Chr 13: 53.12 – 53.14 Mb | |||||||
| PubMed search | [3] | [4] | |||||||
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Nuclear factor, interleukin 3 regulated, also known as NFIL3 or E4BP4 is a protein which in humans is encoded by the NFIL3 gene.[5]
Function
Expression of interleukin-3 (
Transcription initiation depends on the activating capacity of specific protein factors, such as NFIL3, that bind to regulatory regions of the gene, usually upstream of the transcription start site.[5][6]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000165030 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000056749 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b "Entrez Gene: NFIL3 nuclear factor, interleukin 3 regulated".
- PMID 7565758.
Further reading
- Cowell IG, Skinner A, Hurst HC (July 1992). "Transcriptional repression by a novel member of the bZIP family of transcription factors". Molecular and Cellular Biology. 12 (7): 3070–7. PMID 1620116.
- Zhang W, Zhang J, Kornuc M, Kwan K, Frank R, Nimer SD (November 1995). "Molecular cloning and characterization of NF-IL3A, a transcriptional activator of the human interleukin-3 promoter". Molecular and Cellular Biology. 15 (11): 6055–63. PMID 7565758.
- Matoba R, Okubo K, Hori N, Fukushima A, Matsubara K (September 1994). "The addition of 5'-coding information to a 3'-directed cDNA library improves analysis of gene expression". Gene. 146 (2): 199–207. PMID 8076819.
- Cowell IG, Hurst HC (September 1996). "Protein-protein interaction between the transcriptional repressor E4BP4 and the TBP-binding protein Dr1". Nucleic Acids Research. 24 (18): 3607–13. PMID 8836190.
- Ikushima S, Inukai T, Inaba T, Nimer SD, Cleveland JL, Look AT (March 1997). "Pivotal role for the NFIL3/E4BP4 transcription factor in interleukin 3-mediated survival of pro-B lymphocytes". Proceedings of the National Academy of Sciences of the United States of America. 94 (6): 2609–14. PMID 9122243.
- Hulme DJ, Blair IP, Dawkins JL, Nicholson GA (June 2000). "Exclusion of NFIL3 as the gene causing hereditary sensory neuropathy type I by mutation analysis". Human Genetics. 106 (6): 594–6. PMID 10942106.
- Ozkurt IC, Tetradis S (July 2003). "Parathyroid hormone-induced E4BP4/NFIL3 down-regulates transcription in osteoblasts". The Journal of Biological Chemistry. 278 (29): 26803–9. PMID 12743120.
- Priceman SJ, Kirzner JD, Nary LJ, Morris D, Shankar DB, Sakamoto KM, Medh RD (June 2006). "Calcium-dependent upregulation of E4BP4 expression correlates with glucocorticoid-evoked apoptosis of human leukemic CEM cells". Biochemical and Biophysical Research Communications. 344 (2): 491–9. PMID 16630563.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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