NFKB1
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| Location (UCSC) | Chr 4: 102.5 – 102.62 Mb | Chr 3: 135.29 – 135.4 Mb | |||||||
| PubMed search | [3] | [4] | |||||||
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Nuclear factor NF-kappa-B p105 subunit is a protein that in humans is encoded by the NFKB1 gene.[5]
This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappaB (NF-κB) protein complex. NF-κB is a transcription factor that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NF-κB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions; over 200 known genes are targets of NF-κB in various cell types, under specific conditions. Inappropriate activation of NF-κB has been associated with a number of inflammatory diseases while persistent inhibition of NF-κB leads to inappropriate immune cell development or delayed cell growth.[6]
Interactions
NFKB1 has been shown to
interact
with:
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000109320 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028163 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- PMID 1992489.
- ^ "Entrez Gene: NF-κB nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105)".
- ^ PMID 10469655.
- PMID 14678988.
- PMID 8428580.
- PMID 11931769.
- S2CID 39605320.
- PMID 11158290.
- PMID 12244126.
- PMID 11313474.
- PMID 9738011.
- PMID 10023675.
- S2CID 17679498.
- ^ S2CID 11683986.
- S2CID 4391108.
- PMID 11526476.
- PMID 9315679.
- PMID 8642313.
- PMID 11418662.
- PMID 10847592.
- PMID 9556555.
- PMID 8798655.
- PMID 12057007.
- PMID 9584180.
- PMID 11468175.
Further reading
- Baldwin AS (1996). "The NF-kappa B and I kappa B proteins: new discoveries and insights". Annu. Rev. Immunol. 14: 649–83. PMID 8717528.
- Snásel J, Pichová I (1997). "The cleavage of host cell proteins by HIV-1 protease". Folia Biol. (Praha). 42 (5): 227–30. S2CID 7617882.
- Chen F, Castranova V, Shi X, Demers LM (1999). "New insights into the role of nuclear factor-kappaB, a ubiquitous transcription factor in the initiation of diseases". Clin. Chem. 45 (1): 7–17. PMID 9895331.
- Bottex-Gauthier C, Pollet S, Favier A, Vidal DR (2002). "[The Rel/NF-kappa-B transcription factors: complex role in cell regulation]". Pathol. Biol. 50 (3): 204–11. PMID 11980335.
- Garg A, Aggarwal BB (2002). "Nuclear transcription factor-kappaB as a target for cancer drug development". Leukemia. 16 (6): 1053–68. PMID 12040437.
- Sun Z, Andersson R (2003). "NF-kappaB activation and inhibition: a review". Shock. 18 (2): 99–106. PMID 12166787.
- Mercurio AM (2003). "Invasive skin carcinoma--Ras and alpha6beta4 integrin lead the way". Cancer Cell. 3 (3): 201–2. PMID 12676577.
- Sun SC, Xiao G (2004). "Deregulation of NF-kappaB and its upstream kinases in cancer". Cancer Metastasis Rev. 22 (4): 405–22. S2CID 44227245.
- Kucharczak J, Simmons MJ, Fan Y, Gélinas C (2004). "To be, or not to be: NF-kappaB is the answer--role of Rel/NF-kappaB in the regulation of apoptosis". Oncogene. 22 (56): 8961–82. PMID 14663476.
- Suh J, Rabson AB (2004). "NF-kappaB activation in human prostate cancer: important mediator or epiphenomenon?". J. Cell. Biochem. 91 (1): 100–17. S2CID 84116960.
- Muthumani K, Desai BM, Hwang DS, Choo AY, Laddy DJ, Thieu KP, Rao RG, Weiner DB (2004). "HIV-1 Vpr and anti-inflammatory activity". DNA Cell Biol. 23 (4): 239–47. PMID 15142381.
- Schmitz ML, Mattioli I, Buss H, Kracht M (2005). "NF-kappaB: a multifaceted transcription factor regulated at several levels". ChemBioChem. 5 (10): 1348–58. S2CID 85775279.
- Pise-Masison CA, Brady JN (2006). "Setting the stage for transformation: HTLV-1 Tax inhibition of p53 function". Front. Biosci. 10 (1–3): 919–30. S2CID 35215552.
- Joseph AM, Kumar M, Mitra D (2005). "Nef: "necessary and enforcing factor" in HIV infection". Curr. HIV Res. 3 (1): 87–94. PMID 15638726.
- Le Rouzic E, Benichou S (2006). "The Vpr protein from HIV-1: distinct roles along the viral life cycle". Retrovirology. 2: 11. PMID 15725353.
- Zhao RY, Elder RT (2005). "Viral infections and cell cycle G2/M regulation". Cell Res. 15 (3): 143–9. PMID 15780175.
- Zhao RY, Bukrinsky M, Elder RT (2005). "HIV-1 viral protein R (Vpr) & host cellular responses". Indian J. Med. Res. 121 (4): 270–86. PMID 15817944.
- Muthumani K, Choo AY, Hwang DS, Ugen KE, Weiner DB (2006). "HIV-1 Vpr: enhancing sensitivity of tumors to apoptosis". Current Drug Delivery. 1 (4): 335–44. PMID 16305395.
- Courtois G, Smahi A (2006). "NF-kappaB-related genetic diseases". Cell Death Differ. 13 (5): 843–51. PMID 16397577.
- Mattson MP, Meffert MK (2006). "Roles for NF-kappaB in nerve cell survival, plasticity, and disease". Cell Death Differ. 13 (5): 852–60. PMID 16397579.
- Schmitz ML, Krappmann D (2006). "Controlling NF-kappaB activation in T cells by costimulatory receptors". Cell Death Differ. 13 (5): 834–42. PMID 16410801.
- Janssens S, Tschopp J (2006). "Signals from within: the DNA-damage-induced NF-kappaB response". Cell Death Differ. 13 (5): 773–84. PMID 16410802.
- Perkins ND, Gilmore TD (2006). "Good cop, bad cop: the different faces of NF-kappaB". Cell Death Differ. 13 (5): 759–72. PMID 16410803.
- Weil R, Israël A (2006). "Deciphering the pathway from the TCR to NF-kappaB". Cell Death Differ. 13 (5): 826–33. PMID 16439988.
- Kim HJ, Hawke N, Baldwin AS (2006). "NF-kappaB and IKK as therapeutic targets in cancer". Cell Death Differ. 13 (5): 738–47. PMID 16485028.
- Braun T, Carvalho G, Fabre C, Grosjean J, Fenaux P, Kroemer G (2006). "Targeting NF-kappaB in hematologic malignancies". Cell Death Differ. 13 (5): 748–58. PMID 16498458.
- Bottero V, Withoff S, Verma IM (2006). "NF-kappaB and the regulation of hematopoiesis". Cell Death Differ. 13 (5): 785–97. PMID 16528384.
- Xiao G (2007). "Autophagy and NF-κB fight for fate". Cytokine Growth Factor Rev. 18 (3–4): 233–43. PMID 17485237.
External links
- NFKB1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- FactorBook NFKB
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.