NKX6-1
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| Location (UCSC) | Chr 4: 84.49 – 84.5 Mb | Chr 5: 101.81 – 101.81 Mb | |||||||
| PubMed search | [3] | [4] | |||||||
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Homeobox protein Nkx-6.1 is a protein that in humans is encoded by the NKX6-1 gene.[5][6]
Function
In the pancreas, NKX6.1 is required for the development of beta cells and is a potent bifunctional transcription regulator that binds to AT-rich sequences within the promoter region of target genes.[6]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000163623 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000035187 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- PMID 9119408.
- ^ a b "Entrez Gene: NK6 homeobox 1".
Further reading
- Schisler JC, Fueger PT, Babu DA, et al. (2008). "Stimulation of human and rat islet beta-cell proliferation with retention of function by the homeodomain transcription factor Nkx6.1". Mol. Cell. Biol. 28 (10): 3465–76. PMID 18347054.
- Hori Y, Gu X, Xie X, Kim SK (2005). "Differentiation of insulin-producing cells from human neural progenitor cells". PLOS Med. 2 (4): e103. PMID 15839736.
- Jørgensen MC, Vestergírd Petersen H, Ericson J, et al. (1999). "Cloning and DNA-binding properties of the rat pancreatic beta-cell-specific factor Nkx6.1". FEBS Lett. 461 (3): 287–94. S2CID 1735843.
- Iype T, Taylor DG, Ziesmann SM, et al. (2004). "The transcriptional repressor Nkx6.1 also functions as a deoxyribonucleic acid context-dependent transcriptional activator during pancreatic beta-cell differentiation: evidence for feedback activation of the nkx6.1 gene by Nkx6.1". Mol. Endocrinol. 18 (6): 1363–75. PMID 15056733.
- Yokoi N, Kanamori M, Horikawa Y, et al. (2006). "Association studies of variants in the genes involved in pancreatic beta-cell function in type 2 diabetes in Japanese subjects". Diabetes. 55 (8): 2379–86. PMID 16873704.
- Zhu S, Xia HH, Yang Y, et al. (2009). "Alterations of gastric homeoprotein expression in Helicobacter pylori infection, incisural antralisation, and intestinal metaplasia". Dig. Dis. Sci. 54 (5): 996–1002. S2CID 25173708.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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