NOD mice
Non-obese diabetic or NOD
History
Non-obese diabetic (NOD) mice exhibit a susceptibility to spontaneous development of autoimmune
Susceptibility
The susceptibility to IDDM is
NOD mice are also susceptible to developing other
Identifying IDDM susceptibility loci
Genetic Loci associated with susceptibility to IDDM have been identified in the NOD mouse strain through the development of congenic mouse strains, which have identified several insulin dependent diabetes (Idd) loci. The most important is idd1 which is the major histocompatibility complex class II loci I-Ag7.[12]
NOD mice have polymorphisms in the Idd3 locus which are linked to IL-2 production. IL-2 promotes either immunity or tolerance in a concentration dependent fashion by acting on T helper cells, CTL and NK cells. Low amounts of IL-2 may be needed to promote survival of Treg in mice. Loss of IL-2 can thereby contribute to the development of autoimmunity in NOD mice.[13]
NOD mice have a mutation in exon 2 of the
References
- ^ "Non-Obese Diabetic (NOD) Mouse BAC Library". National Institute of Allergy and Infectious Diseases. Retrieved 2006-05-15.
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- ^ Leiter, Edward H (1994). "The NOD Mouse: A Model for Analyzing the Interplay Between Heredity and the Environment in the Development of Autoimmune Disease". ILAR Journal. 35 (1): 4–14. .
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