NOS1
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| Location (UCSC) | Chr 12: 117.21 – 117.45 Mb | Chr 5: 117.92 – 118.1 Mb | |||||||
| PubMed search | [3] | [4] | |||||||
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Nitric oxide synthase 1 (neuronal), also known as NOS1, is an enzyme that in humans is encoded by the NOS1 gene.[5][6]
Function
NADPH, and tetrahydrobiopterin.[8]
Clinical significance
It has been implicated in
psychostimulant neurotoxicity. It has also been investigated with respect to bipolar disorder[14] and air pollution exposure.[15]
Interactions
NOS1 has been shown to
See also
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000089250 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029361 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- PMID 1385308.
- PMID 7682706.
- PMID 1379716.
- ^ "Entrez Gene: NOS1 Nitric oxide synthase 1 (neuronal)".
- PMID 10641565. Archived from the originalon 2013-01-05.
- S2CID 24110873.
- PMID 12140778.
- PMID 16389274.
- S2CID 42425890.
- S2CID 45596789.
- ^ Steenackers W, De Herdt E, De Boever P, Bos I, Int Panis L (2013). "Neuroinflammation induced by air pollution: gene expression analysis in laboratory animals". Master Thesis, GROUP T – Leuven Engineering College.
- ^ S2CID 14613261.
- S2CID 15834673.
Further reading
- Miyagoe-Suzuki Y, Takeda SI (2001). "Association of neuronal nitric oxide synthase (nNOS) with alpha1-syntrophin at the sarcolemma". Microsc. Res. Tech. 55 (3): 164–70. S2CID 28225242.
- Waddington SN (2002). "Arginase in glomerulonephritis". Kidney Int. 61 (3): 876–81. PMID 11849441.
- Rotilio G, Aquilano K, Ciriolo MR (2004). "Interplay of Cu,Zn superoxide dismutase and nitric oxide synthase in neurodegenerative processes". IUBMB Life. 55 (10–11): 629–34. S2CID 19518719.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
PDB gallery | |
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![1k2u: Structure of rat brain nNOS heme domain complexed with S-ethyl-N-[4-(trifluoromethyl)phenyl] isothiourea](/File:PDB_1k2u_EBI.jpg)
![1p6i: Rat neuronal NOS heme domain with (4S)-N-(4-amino-5-[aminoethyl]aminopentyl)-N'-nitroguanidine bound](/File:PDB_1p6i_EBI.jpg)
![2hx3: Rat nNOS heme domain complexed with (4S)-N-{4-Amino-5-[(2-aminoethyl)-hydroxyamino]-pentyl}-N'-nitroguanidine](/File:PDB_2hx3_EBI.jpg)
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