NS1 antigen test
| NS1 antigen test | |
|---|---|
Crystal structure of the dengue virus, which causes dengue fever | |
| ICD-10-PCS | A90 |
| LOINC | 75377-2 |
NS1 antigen test (nonstructural protein 1) is a test for
enzyme-linked immunosorbent assay.[1][2] India has introduced in 2010 the NS1 test costing 1,600 rupees at a private hospital in Mumbai.[2]
Medical use
The medical use of the NS1 antigen test can be defined to diagnose dengue infections and is effective to 1st day detection. Additionally, NS1 assay is useful for differential diagnostics in regards to
flaviviruses.[3]
NS1 is present in the serum of infected persons directly at the onset of clinical symptoms in primary dengue infection and produces a strong humoral response. It is detectable before the appearance of IgM antibodies.[4]
DENV by NS1 antigen is laboratory confirmation of dengue in people also assessing clinical aspects (as well as, taking into account where the individual may have traveled recently).[5] Serological tests such as an immunoglobulin M antibody capture–enzyme-linked immunosorbent assay (MAC-ELISA) and viral RNA detection by reverse transcriptase (RT-PCR) can also be used to diagnose dengue fever.[6]
See also
References
- ^ a b "Bio-Rad Launches Test for Early Diagnosis of the Dengue Virus | SelectScience". www.selectscience.net.
- ^ a b Debroy, Sumitra (September 16, 2010). "Now, get dengue test results in just 48 hours". The Times of India.
- ^ "CDC - Laboratory Guidance - Dengue". www.cdc.gov. Retrieved 2015-12-01.
- PMID 24434336.
- ^ "Dengue - Chapter 3 - 2016 Yellow Book | Travelers' Health | CDC". wwwnc.cdc.gov. Retrieved 2015-12-01.
- PMID 27834337.
Further reading
- Peeling, Rosanna W.; Artsob, Harvey; Pelegrino, Jose Luis; Buchy, Philippe; Cardosa, Mary J.; Devi, Shamala; Enria, Delia A.; Farrar, Jeremy; Gubler, Duane J.; Guzman, Maria G.; Halstead, Scott B.; Hunsperger, Elizabeth; Kliks, Susie; Margolis, Harold S.; Nathanson, Carl M.; Nguyen, Vinh Chau; Rizzo, Nidia; Vázquez, Susana; Yoksan, Sutee (1 December 2010). "Evaluation of diagnostic tests: dengue". Nature Reviews Microbiology. 8 (12 Suppl): S30–S37. PMID 21548185.
- "The Importance of Accurate Diagnosis of Dengue Fever". www.medscape.com. Medscape. Retrieved 26 July 2016.
- Tricou, V.; Vu, H. T.; Quynh, N. V.; Nguyen, C. V.; Tran, H. T.; Farrar, J.; Wills, B.; Simmons, C. P. (2010). "Comparison of two dengue NS1 rapid tests for sensitivity, specificity and relationship to viraemia and antibody responses". BMC Infectious Diseases. 10: 142. PMID 20509940.
- Pal, Subhamoy; Dauner, Allison L.; Mitra, Indrani; Forshey, Brett M.; Garcia, Paquita; Morrison, Amy C.; Halsey, Eric S.; Kochel, Tadeusz J.; Wu, Shuenn-Jue L. (2014-11-20). "Evaluation of Dengue NS1 Antigen Rapid Tests and ELISA Kits Using Clinical Samples". PLOS ONE. 9 (11): e113411. PMID 25412170.
- Paranavitane, Shiran Ajith; Gomes, Laksiri; Kamaladasa, Achala; Adikari, Thiruni N; Wickramasinghe, Nilanka; Jeewandara, Chandima; Shyamali, Narangoda Liyanage Ajantha; Ogg, Graham Stuart; Malavige, Gathsaurie Neelika (31 October 2014). "Dengue NS1 antigen as a marker of severe clinical disease". BMC Infectious Diseases. 14 (1): 570. PMID 25366086.
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