Nonsteroidal anti-inflammatory drug

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Non-steroidal anti-inflammatory drug
Drug class
Film-coated 200 mg tablets of generic ibuprofen, a common non-steroidal anti-inflammatory drug
Class identifiers
Pronunciation/ˈɛnsɛd/ EN-sed
Synonyms
  • Cyclooxygenase inhibitor[2]
  • Cyclooxygenase enzyme inhibitor[2]
  • Non-steroidal anti-inflammatory agent/analgesic (NSAIA)
  • Non-steroidal anti-inflammatory medicine (NSAIM)[citation needed]
Use
COX-2
Legal status
In Wikidata
NSAID identification on label of generic ibuprofen, an over-the-counter non-steroidal anti-inflammatory drug

Non-steroidal anti-inflammatory drugs

heart attack, and kidney disease.[5][6]

The term non-steroidal, common from around 1960, distinguishes these drugs from

corticosteroids, which during the 1950s had acquired a bad reputation due to overuse and side-effect problems after their initial introduction in 1948.[7][8][9]

NSAIDs work by inhibiting the activity of

COX-2 isoenzymes). In cells, these enzymes are involved in the synthesis of key biological mediators, namely prostaglandins, which are involved in inflammation, and thromboxanes, which are involved in blood clotting
.

There are two general types of NSAIDs available: non-selective, and

COX-2 selective.[10] Most NSAIDs are non-selective, and inhibit the activity of both COX-1 and COX-2. These NSAIDs, while reducing inflammation, also inhibit platelet aggregation and increase the risk of gastrointestinal ulcers and bleeds.[10] COX-2 selective inhibitors have fewer gastrointestinal side effects, but promote thrombosis, and some of these agents substantially increase the risk of heart attack. As a result, certain COX-2 selective inhibitors—such as rofecoxib—are no longer used due to the high risk of undiagnosed vascular disease.[10] These differential effects are due to the different roles and tissue localisations of each COX isoenzyme.[10] By inhibiting physiological COX activity, NSAIDs may cause deleterious effects on kidney function,[11] and, perhaps as a result of water and sodium retention and decreases in renal blood flow, may lead to heart problems.[12] In addition, NSAIDs can blunt the production of erythropoietin
, resulting in anaemia, since haemoglobin needs this hormone to be produced.

The most prominent NSAIDs are

endocannabinoid reuptake almost exclusively within the brain, and only minimally in the rest of the body.[14][15]

Medical uses

NSAIDs are often suggested for the treatment of acute or chronic conditions where pain and inflammation are present. NSAIDs are generally used for the symptomatic relief of the following conditions:[16][17][18]

Chronic pain and cancer-related pain

The effectiveness of NSAIDs for treating non-cancer chronic pain and cancer-related pain in children and adolescents is not clear.[26][27] There have not been sufficient numbers of high-quality randomised controlled trials conducted.[26][27]

Inflammation

Differences in anti-inflammatory activity between the various individual NSAIDs are small, but there is considerable variation among individual patients in therapeutic response and tolerance to these drugs. About 60% of patients will respond to any NSAID; of the others, those who do not respond to one may well respond to another. Pain relief starts soon after taking the first dose, and a full analgesic effect should normally be obtained within a week, whereas an anti-inflammatory effect may not be achieved (or may not be clinically assessable) for up to three weeks. If appropriate responses are not obtained within these times, another NSAID should be tried.[3]

Surgical pain

Pain following surgery can be significant, and many people require strong pain medications such as opioids. There is some low-certainty evidence that starting NSAID painkiller medications in adults early, before surgery, may help reduce post-operative pain, and also reduce the dose or quantity of opioid medications required after surgery.[28] Any increase risk of surgical bleeding, bleeding in the gastrointestinal system, myocardial infarctions, or injury to the kidneys has not been well studied.[28] When used in combination with paracetamol, the analgesic effect on post-operative pain may be improved.[29]

Aspirin

COX-1, is also indicated for antithrombosis through inhibition of platelet aggregation. This is useful for the management of arterial thrombosis, and prevention of adverse cardiovascular events like heart attacks. Aspirin inhibits platelet aggregation by inhibiting the action of thromboxane A2.[30]

Dentistry

NSAIDs are useful in the management of post-operative dental pain following invasive dental procedures such as dental extraction. When not contra-indicated, they are favoured over the use of paracetamol alone due to the anti-inflammatory effect they provide.[31] There is weak evidence suggesting that taking pre-operative analgesia can reduce the length of post operative pain associated with placing orthodontic spacers under local anaesthetic.[32]

Alzheimer's disease

Based on observational studies and randomized controlled trials, NSAID use is not effective for the treatment or prevention of Alzheimer's disease.[33][34]

Contraindications

NSAIDs may be used with caution by people with the following conditions:

  • Persons who are over age 50, and who have a family history of gastrointestinal (GI) problems[17]
  • Persons who have had previous gastrointestinal problems from NSAID use[17]

NSAIDs should usually be avoided by people with the following conditions:

Adverse effects

The widespread use of NSAIDs has meant that the adverse effects of these drugs have become increasingly common. Use of NSAIDs increases risk of a range of

gastrointestinal (GI) problems, kidney disease and adverse cardiovascular events.[39][40] As commonly used for post-operative pain, there is evidence of increased risk of kidney complications.[41] Their use following gastrointestinal surgery remains controversial, given mixed evidence of increased risk of leakage from any bowel anastomosis created.[42][43][44]

An estimated 10–20% of people taking NSAIDs experience indigestion. In the 1990s high doses of prescription NSAIDs were associated with serious upper gastrointestinal adverse events, including bleeding.[45]

NSAIDs, like all medications, may interact with other medications. For example, concurrent use of NSAIDs and quinolone antibiotics may increase the risk of quinolones' adverse central nervous system effects, including seizure.[46][47]

There is an argument over the benefits and risks of NSAIDs for treating chronic musculoskeletal pain. Each drug has a benefit-risk profile and balancing the risk of no treatment with the competing potential risks of various therapies should be considered.[48] For people over the age of 65 years old, the balance between the benefits of pain-relief medications such as NSAIDS and the potential for adverse effects has not been well determined.[49]

There is some evidence suggesting that, for some people, use of NSAIDs (or other anti-inflammatories) may contribute to the initiation of chronic pain.[50]

In October 2020, the U.S. Food and Drug Administration (FDA) required the drug label to be updated for all nonsteroidal anti-inflammatory medications to describe the risk of kidney problems in unborn babies that result in low amniotic fluid.[51][52] They are recommending avoiding NSAIDs in pregnant women at 20 weeks or later in pregnancy.[51][52]

Combinational risk

If a

COX-2 inhibitor is taken, a traditional NSAID (prescription or over-the-counter) should not be taken at the same time.[53]

Rofecoxib (Vioxx) was shown to produce significantly fewer gastrointestinal adverse drug reactions (ADRs) compared with naproxen.[54] The study, the VIGOR trial, raised the issue of the cardiovascular safety of the coxibs (COX-2 inhibitors). A statistically significant increase in the incidence of myocardial infarctions was observed in patients on rofecoxib. Further data, from the APPROVe trial, showed a statistically significant relative risk of cardiovascular events of 1.97 versus placebo[55]—which caused a worldwide withdrawal of rofecoxib in October 2004.[56]

Use of methotrexate together with NSAIDs in rheumatoid arthritis is safe, if adequate monitoring is done.[57]

Cardiovascular

NSAIDs, aside from aspirin, increase the risk of myocardial infarction and stroke.[58][59] This occurs at least within a week of use.[5] They are not recommended in those who have had a previous heart attack as they increase the risk of death or recurrent MI.[60] Evidence indicates that naproxen may be the least harmful out of these.[59][61]

NSAIDs aside from (low-dose) aspirin are associated with a doubled risk of heart failure in people without a history of cardiac disease.[61] In people with such a history, use of NSAIDs (aside from low-dose aspirin) was associated with a more than 10-fold increase in heart failure.[62] If this link is proven causal, researchers estimate that NSAIDs would be responsible for up to 20 percent of hospital admissions for congestive heart failure. In people with heart failure, NSAIDs increase mortality risk (hazard ratio) by approximately 1.2–1.3 for naproxen and ibuprofen, 1.7 for rofecoxib and celecoxib, and 2.1 for diclofenac.[63]

On 9 July 2015, the

heart attack and stroke risk associated with nonsteroidal anti-inflammatory drugs (NSAIDs) other than aspirin.[64]

Possible erectile dysfunction risk

A 2005 Finnish survey study found an association between long term (over three months) use of NSAIDs and erectile dysfunction.[65]

A 2011 publication[66] in The Journal of Urology received widespread publicity.[67] According to the study, men who used NSAIDs regularly were at significantly increased risk of erectile dysfunction. A link between NSAID use and erectile dysfunction still existed after controlling for several conditions. However, the study was observational and not controlled, with low original participation rate, potential participation bias, and other uncontrolled factors. The authors warned against drawing any conclusion regarding cause.[68]

Gastrointestinal

The main

prostaglandins.[39] Inhibition of prostaglandin synthesis in the GI tract causes increased gastric acid secretion, diminished bicarbonate secretion, diminished mucus secretion and diminished trophic effects on the epithelial mucosa.[69]

Common gastrointestinal side effects include:[16]

Clinical NSAID ulcers are related to the systemic effects of NSAID administration. Such damage occurs irrespective of the route of administration of the NSAID (e.g., oral, rectal, or parenteral) and can occur even in people who have achlorhydria.[71]

Ulceration risk increases with therapy duration, and with higher doses. To minimize GI side effects, it is prudent to use the lowest effective dose for the shortest period of time—a practice that studies show is often not followed. Over 50% of patients who take NSAIDs have sustained some mucosal damage to their small intestine.[72]

The risk and rate of gastric adverse effects is different depending on the type of NSAID medication a person is taking.

Indomethacin, ketoprofen, and piroxicam use appear to lead to the highest rate of gastric adverse effects, while ibuprofen (lower doses) and diclofenac appear to have lower rates.[16]

Certain NSAIDs, such as aspirin, have been marketed in enteric-coated formulations that manufacturers claim reduce the incidence of gastrointestinal ADRs. Similarly, some believe that rectal formulations may reduce gastrointestinal ADRs. However, consistent with the systemic mechanism of such ADRs, and in clinical practice, these formulations have not demonstrated a reduced risk of GI ulceration.[16]

Numerous "gastro-protective" drugs have been developed with the goal of preventing gastrointestinal toxicity in people who need to take NSAIDs on a regular basis.

proton pump inhibitors (e.g.: omeprazole and esomeprazole), or by treatment with a drug that mimics prostaglandin in order to restore the lining of the GI tract (e.g.: a prostaglandin analog misoprostol).[39] Diarrhea is a common side effect of misoprostol; however, higher doses of misoprostol have been shown to reduce the risk of a person having a complication related to a gastric ulcer while taking NSAIDs.[39] While these techniques may be effective, they are expensive for maintenance therapy.[73]

Hydrogen sulfide NSAID hybrids prevent the gastric ulceration/bleeding associated with taking the NSAIDs alone. Hydrogen sulfide is known to have a protective effect on the cardiovascular and gastrointestinal system.[74]

Inflammatory bowel disease

NSAIDs should be used with caution in individuals with inflammatory bowel disease (e.g., Crohn's disease or ulcerative colitis) due to their tendency to cause gastric bleeding and form ulceration in the gastric lining.[75]

Renal

NSAIDs are also associated with a fairly high incidence of adverse drug reactions (

kidney function. This is particularly important in kidney failure where the kidney is trying to maintain renal perfusion pressure by elevated angiotensin II levels. At these elevated levels, angiotensin II also constricts the afferent arteriole into the glomerulus in addition to the efferent arteriole it normally constricts. Since NSAIDs block this prostaglandin-mediated effect of afferent arteriole dilation, particularly in kidney failure, NSAIDs cause unopposed constriction of the afferent arteriole and decreased RPF (renal perfusion flow) and GFR.[76]

Common ADRs associated with altered kidney function include:[16]

These agents may also cause kidney impairment, especially in combination with other nephrotoxic agents. Kidney failure is especially a risk if the patient is also concomitantly taking an ACE inhibitor (which removes angiotensin II's vasoconstriction of the efferent arteriole) and a diuretic (which drops plasma volume, and thereby RPF)—the so-called "triple whammy" effect.[77]

In rarer instances NSAIDs may also cause more severe kidney conditions:[16]

NSAIDs in combination with excessive use of phenacetin or paracetamol (acetaminophen) may lead to analgesic nephropathy.[78]

Photosensitivity

Photosensitivity is a commonly overlooked adverse effect of many of the NSAIDs.[79] The 2-arylpropionic acids are the most likely to produce photosensitivity reactions, but other NSAIDs have also been implicated including piroxicam, diclofenac, and benzydamine.[80]

Benoxaprofen, since withdrawn due to its liver toxicity, was the most photoactive NSAID observed. The mechanism of photosensitivity, responsible for the high photoactivity of the 2-arylpropionic acids, is the ready decarboxylation of the carboxylic acid moiety. The specific absorbance characteristics of the different chromophoric 2-aryl substituents, affects the decarboxylation mechanism.[81]

During pregnancy

While NSAIDs as a class are not direct

indomethacin can be used in pregnancy to treat polyhydramnios by reducing fetal urine production via inhibiting fetal renal blood flow.[86]

In contrast, paracetamol (acetaminophen) is regarded as being safe and well tolerated during pregnancy, but Leffers et al. released a study in 2010, indicating that there may be associated male infertility in the unborn.[87][88] Doses should be taken as prescribed, due to risk of liver toxicity with overdoses.[89]

In France, the country's health agency contraindicates the use of NSAIDs, including aspirin, after the sixth month of pregnancy.[90]

In October 2020, the U.S. Food and Drug Administration (FDA) required the drug label to be updated for all nonsteroidal anti-inflammatory medications to describe the risk of kidney problems in unborn babies that result in low amniotic fluid.[51][52] They are recommending avoiding NSAIDs in pregnant women at 20 weeks or later in pregnancy.[51][52]

Allergy and allergy-like hypersensitivity reactions

A variety of allergic or allergic-like

urticarial lesions or angioedema.[38]

Possible effects on bone and soft tissue healing

It has been hypothesized that NSAIDs may delay healing from bone and soft-tissue injuries by inhibiting inflammation.[92] On the other hand, it has also been hypothesized that NSAIDs might speed recovery from soft tissue injuries by preventing inflammatory processes from damaging adjacent, non-injured muscles.[93]

There is moderate evidence that they delay bone healing.[94] Their overall effect on soft-tissue healing is unclear.[93][92][95]

Ototoxicity

Long-term use of NSAID analgesics and paracetamol is associated with an increased risk of hearing loss.[96][97][98]

Other

The use of NSAIDs for analgesia following gastrointestinal surgery remains controversial, given mixed evidence of an increased risk of leakage from any bowel anastomosis created. This risk may vary according to the class of NSAID prescribed.[42][43][44]

Common adverse drug reactions (ADR), other than listed above, include: raised liver

abnormally high level of potassium in the blood, confusion, spasm of the airways, and rash.[16] Ibuprofen may also rarely cause irritable bowel syndrome symptoms. NSAIDs are also implicated in some cases of Stevens–Johnson syndrome.[99]

Most NSAIDs penetrate poorly into the central nervous system (CNS). However, the COX enzymes are expressed constitutively in some areas of the CNS, meaning that even limited penetration may cause adverse effects such as somnolence and dizziness.[100]

NSAIDs may increase the risk of bleeding in patients with Dengue fever[101] For this reason, NSAIDs are only available with a prescription in India.[102]

In very rare cases, ibuprofen can cause aseptic meningitis.[103]

As with other drugs, allergies to NSAIDs might exist. While many allergies are specific to one NSAID, up to 1 in 5 people may have unpredictable cross-reactive allergic responses to other NSAIDs as well.[104]

Immune response

Although small doses generally have little to no effect on the immune system, large doses of NSAIDs significantly suppress the production of immune cells.[105] As NSAIDs affect prostaglandins, they affect the production of most fast growing cells.[105] This includes immune cells.[105] Unlike corticosteroids, they do not directly suppress the immune system and so their effect on the immune system is not immediately obvious.[105] They suppress the production of new immune cells, but leave existing immune cells functional.[105] Large doses slowly reduce the immune response as the immune cells are renewed at a much lower rate.[105] Causing a gradual reduction of the immune system, much slower and less noticeable than the immediate effect of Corticosteroids.[105] The effect significantly increases with dosage, in a nearly exponential rate.[105] Doubling of dose reduced cells by nearly four times.[105] Increasing dose by five times reduced cell counts to only a few percent of normal levels.[105] This is likely why the effect was not immediately obvious in low dose trials, as the effect is not apparent until much higher dosages are tested.[105]

Interactions

NSAIDs reduce kidney blood flow and thereby decrease the efficacy of

lithium and methotrexate.[106]

NSAIDs cause

decreased ability to form blood clots, which can increase the risk of bleeding when combined with other drugs that also decrease blood clotting, such as warfarin.[106]

NSAIDs may aggravate

NSAIDs may interfere and reduce effectiveness of

IFNγ, both of which are cytokine derivatives.[108][109] NSAIDs, when used in combination with SSRIs, increase the risk of adverse gastrointestinal effects.[110] NSAIDs, when used in combination with SSRIs, increase the risk of internal bleeding and brain hemorrhages.[111]

Various widely used NSAIDs enhance

NSAIDs may reduce the effectiveness of antibiotics. An in-vitro study on cultured bacteria found that adding NSAIDs to antibiotics reduced their effectiveness by around 20%.[113]

The concomitant use of NSAIDs with

better source needed
]

Mechanism of action

Most NSAIDs act as nonselective inhibitors of the

reversible (albeit at varying degrees of reversibility), as opposed to the mechanism of aspirin, which is irreversible inhibition.[115] COX catalyzes the formation of prostaglandins and thromboxane from arachidonic acid (itself derived from the cellular phospholipid bilayer by phospholipase A2). Prostaglandins act (among other things) as messenger molecules in the process of inflammation. This mechanism of action was elucidated in 1970 by John Vane (1927–2004), who received a Nobel Prize for his work (see Mechanism of action of aspirin).[116][117]

COX-1 is a constitutively expressed enzyme with a "house-keeping" role in regulating many normal physiological processes. One of these is in the

mucosa from being eroded by its own acid. COX-2 is an enzyme facultatively expressed in inflammation, and it is inhibition of COX-2 that produces the desirable effects of NSAIDs.[118]

When nonselective COX-1/COX-2 inhibitors (such as aspirin, ibuprofen, and naproxen) lower stomach prostaglandin levels, ulcers of the stomach or duodenum and internal bleeding can result.[119] The discovery of COX-2 led to research to the development of selective COX-2 inhibiting drugs that do not cause gastric problems characteristic of older NSAIDs.[120]

NSAIDs have been studied in various assays to understand how they affect each of these enzymes. While the assays reveal differences, unfortunately, different assays provide differing ratios.[121]

Paracetamol (acetaminophen) is not considered an NSAID because it has little anti-inflammatory activity. It treats pain mainly by blocking COX-2 mostly in the central nervous system, but not much in the rest of the body.[14]

However, many aspects of the mechanism of action of NSAIDs remain unexplained, and for this reason, further COX pathways are hypothesized. The

COX-3 pathway was believed to fill some of this gap but recent findings make it appear unlikely that it plays any significant role in humans and alternative explanation models are proposed.[14]

NSAIDs interact with the

endocannabinoids, as COX2 have been shown to utilize endocannabinoids as substrates, and may have a key role in both the therapeutic effects and adverse effects of NSAIDs, as well as in NSAID-induced placebo responses.[122][123][124]

NSAIDs are also used in the acute pain caused by

urate crystal phagocytosis besides inhibition of prostaglandin synthase.[125]

Antipyretic activity

NSAIDs have antipyretic activity and can be used to treat fever.[126][127] Fever is caused by elevated levels of prostaglandin E2 (PGE2), which alters the firing rate of neurons within the hypothalamus that control thermoregulation.[126][128] Antipyretics work by inhibiting the enzyme COX, which causes the general inhibition of prostanoid biosynthesis (PGE2) within the hypothalamus.[126][127] PGE2 signals to the hypothalamus to increase the body's thermal setpoint.[127][129] Ibuprofen has been shown more effective as an antipyretic than paracetamol (acetaminophen).[128][130] Arachidonic acid is the precursor substrate for cyclooxygenase leading to the production of prostaglandins F, D, and E.[131]

Classification

Burana 600 mg – ibuprofen package

NSAIDs can be classified based on their chemical structure or mechanism of action. Older NSAIDs were known long before their mechanism of action was elucidated and were for this reason classified by chemical structure or origin. Newer substances are more often classified by mechanism of action.[132]

Salicylates

Propionic acid derivatives

Acetic acid derivatives

Enolic acid (oxicam) derivatives

Anthranilic acid derivatives (Fenamates)

The following NSAIDs are derived from fenamic acid, which is a derivative of anthranilic acid,[136]: 235  which in turn is a nitrogen isostere of salicylic acid, which is the active metabolite of aspirin.[136]: 235 [137]: 17 

Selective COX-2 inhibitors (Coxibs)

Sulfonanilides

  • Nimesulide (systemic preparations are banned by several countries for the potential risk of hepatotoxicity)[141]

Others

Chirality

Most NSAIDs are chiral molecules; diclofenac and the oxicams are exceptions. However, the majority are prepared as racemic mixtures. Typically, only a single enantiomer is pharmacologically active. For some drugs (typically profens), an isomerase enzyme in vivo converts the inactive enantiomer into the active form, although its activity varies widely in individuals. This phenomenon is likely responsible for the poor correlation between NSAID efficacy and plasma concentration observed in older studies when specific analysis of the active enantiomer was not performed.[medical citation needed]

Ibuprofen and ketoprofen are now available in single-enantiomer preparations (dexibuprofen and dexketoprofen), which purport to offer quicker onset and an improved side-effect profile. Naproxen has always been marketed as the single active enantiomer.[medical citation needed]

Main practical differences

NSAIDs within a group tend to have similar characteristics and tolerability. There is little difference in clinical efficacy among the NSAIDs when used at equivalent doses.

elimination half-life), route of administration, and tolerability profile.[medical citation needed
]

Regarding adverse effects, selective

COX-2 inhibitors have lower risk of gastrointestinal bleeding.[144] With the exception of naproxen, nonselective NSAIDs increase the risk of having a heart attack.[144] Some data also supports that the partially selective nabumetone is less likely to cause gastrointestinal events.[144]

A consumer report noted that ibuprofen, naproxen, and salsalate are less expensive than other NSAIDs, and essentially as effective and safe when used appropriately to treat osteoarthritis and pain.[145]

Pharmacokinetics

Most nonsteroidal anti-inflammatory drugs are weak acids,[146] with a pKa of 3–5. They are absorbed well from the stomach and intestinal mucosa. They are highly protein-bound in plasma (typically >95%), usually to albumin, so that their volume of distribution typically approximates to plasma volume. Most NSAIDs are metabolized in the liver by oxidation and conjugation to inactive metabolites that typically are excreted in the urine, though some drugs are partially excreted in bile. Metabolism may be abnormal in certain disease states, and accumulation may occur even with normal dosage.[medical citation needed]

Ibuprofen and diclofenac have short half-lives (2–3 hours). Some NSAIDs (typically oxicams) have very long half-lives (e.g. 20–60 hours).[medical citation needed]

History

One of the first advertisements for Bayer Aspirin, published in The New York Times in 1917

It is widely believed that naturally occurring salicin in

Dioscorides's De materia medica was arguably the most influential herbal from Roman to Medieval times but, if he mentions willow at all (there is doubt about the identity of 'Itea'), then he used the ashes, steeped in vinegar, as a treatment for corns,[151] which corresponds well with modern uses of salicylic acid
.

Willow bark (from trees of the Salix genus) was widely known to be used as a medicine by multiple First Nations communities.[152] The bark would be chewed or steeped in water for its pain relieving and antipyretic effects. The effects are a result of the bark's salicin content. Meadowsweet, another plant to contain salicin, has strong roots in British folk medicine for the same maladies. Willow bark was first reported in Western science by Edward Stone in 1763 as a treatment for ague (fever) according to the pseudoscientific doctrine of signatures.[153]

In the body, salicin is turned into salicylic acid, which produces the antipyretic and analgesic effects that the plants are known for.

Salicin was first isolated by

Kolbe-Schmitt reaction.[156][157][158]

Kolbe–Schmitt reaction mechanism
Kolbe–Schmitt reaction mechanism

By 1897 the German chemist Felix Hoffmann and the Bayer company prompted a new age of pharmacology by converting salicylic acid into acetylsalicylic acid—named aspirin by Heinrich Dreser. Other NSAIDs like ibuprofen were developed from the 1950s forward.[154] In 2001, NSAIDs accounted for 70,000,000 prescriptions and 30 billion over-the-counter doses sold annually in the United States.[45]

Veterinary use

Research supports the use of NSAIDs for the control of pain associated with veterinary procedures such as dehorning and castration of calves.[citation needed] The best effect is obtained by combining a short-term local anesthetic such as lidocaine with an NSAID acting as a longer term analgesic.[citation needed] However, as different species have varying reactions to different medications in the NSAID family, little of the existing research data can be extrapolated to animal species other than those specifically studied, and the relevant government agency in one area sometimes prohibits uses approved in other jurisdictions.[citation needed]

In the United States, meloxicam is approved for use only in canines, whereas (due to concerns about liver damage) it carries warnings against its use in cats[159][160] except for one-time use during surgery.[161] In spite of these warnings, meloxicam is frequently prescribed "off-label" for non-canine animals including cats and livestock species.[162] In other countries, for example The European Union (EU), there is a label claim for use in cats.[163]

See also

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