Nadolol

Source: Wikipedia, the free encyclopedia.
Nadolol
Clinical data
Trade namesCorgard, others
AHFS/Drugs.comMonograph
MedlinePlusa682666
License data
Routes of
administration		By mouth
Drug classBeta blocker
ATC code
Legal status
Legal status
Pharmacokinetic data
Protein binding30%
MetabolismNot metabolised
Elimination half-life14-24 hours
ExcretionRenal and fecal (unchanged)
Identifiers
  • * rel-(2R,3S)-5-{[(2R)-3-(tert-butylamino)-2-hydroxypropyl]oxy}-1,2,3,4-tetrahydronaphthalene-2,3-diol
    • (2R*,3S*)-5-{[(2R*)-3-(tert-butylamino)-2-hydroxypropyl]oxy}-1,2,3,4-tetrahydronaphthalene-2,3-diol
JSmol)
  • OC(CNC(C)(C)C)COc1cccc2c1C[C@H](O)[C@H](O)C2
  • InChI=1S/C17H27NO4/c1-17(2,3)18-9-12(19)10-22-16-6-4-5-11-7-14(20)15(21)8-13(11)16/h4-6,12,14-15,18-21H,7-10H2,1-3H3/t12?,14-,15+/m1/s1 checkY
  • Key:VWPOSFSPZNDTMJ-UCWKZMIHSA-N checkY
  (verify)

Nadolol, sold under the brand name Corgard among others, is a medication used to treat

heart pain, atrial fibrillation, and some inherited arrhythmic syndromes.[2] It has also been used to prevent migraine headaches and complications of cirrhosis.[3][4] It is taken orally.[3]

Common side effects include dizziness, feeling tired, a

β2-adrenergic receptors in blood vessels.[2]

Nadolol was patented in 1970 and came into medical use in 1978.

generic medication.[2] In 2020, it was the 340th most commonly prescribed medication in the United States, with more than 700 thousand prescriptions.[7]

Medical uses

Nadolol is used to treat

angina pectoris and is approved by the FDA for these purposes.[8]

It is regularly used off-label

thyroid hormone.[11]

Nadolol is the preferred

selective beta blockers or propranolol in the prevention of breakthrough cardiac events.[12] Similarly, it is the preferred type of beta blocker for treatment of patients with CPVT, as it has been shown to be more efficacious than selective beta blockers, like atenolol or bisoprolol.[13]

Nadolol has the advantage of once daily dosing and thus improved patient compliance. For patients with decreased kidney function, nadolol may be dosed less often.

attention deficit/hyperactivity disorder(ADHD)[16] and its use has been explored as a treatment for essential tremor[17] and Parkinson's disease[18] but neither is well established.[19][20][21]

Side effects

The most common side effects include dizziness and fatigue.[18]

Contraindications

Nadolol and other beta blockers should be used with cautions in people with heart failure and its use should not be abruptly stopped. It is contraindicated for people with asthma, a slow heart rate and certain severe heart problems.[22]

Pharmacology

Pharmacodynamics

Four stereoisomers of nadolol

Nadolol is a non-selective

airways, leads to airway constriction similar to that seen in asthma. Inhibition of beta-1 receptors in the juxtaglomerular apparatus of the kidney inhibits the renin–angiotensin system, causing a decrease in vasoconstriction
and a decrease in water retention. Nadolol's inhibition of beta-1 receptors in the heart and kidney leads to its effects on lowering blood pressure.

The drug impairs AV node conduction and decreases sinus rate.

Nadolol may also increase

HDL-cholesterol levels. [citation needed
]

Pharmacokinetics

Nadolol is classified as a beta blocker with low

neuropsychiatric side effects.[23]

Chemistry

Nadolol is a mixture of

stereoisomers. It is polar and hydrophilic, with low lipid solubility.[24]

References

  1. FDA
    . Retrieved 22 Oct 2023.
  2. ^ a b c d e "Nadolol Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Retrieved 3 March 2019.
  3. ^
    ISBN 9780857113382
    .
  4. ^
    PMID 24714633
    .
  5. ^ "Nadolol Pregnancy and Breastfeeding Warnings". Drugs.com. Retrieved 3 March 2019.
  6. ISBN 9783527607495
    .
  7. ^ "Nadolol - Drug Usage Statistics". ClinCalc. Retrieved 7 October 2022.
  8. ^ a b Nadolol entry in AccessMedicine. McGraw-Hill Global Education Holdings, LLC. Accessed 8 November 2014
  9. PMID 24682347
    .
  10. PMID 22529202
    .
  11. S2CID 29669311
    .
  12. PMID 29650123
    .
  13. S2CID 247792342
    .
  14. ^ "Corgard (nadolol) dosing, indications, interactions, adverse effects, and more". reference.medscape.com. Retrieved 27 May 2017.
  15. ^ "Nadolol - a beta-blocker - Corgard. High blood pressure drugs". patient.info. Retrieved 27 May 2017.
  16. ISBN 9781593852276
    . Retrieved 27 May 2017 – via Google Books.
  17. PMID 22013182
    .
  18. ^ a b U.S. National Library of Medicine Nadolol entry in Medline Plus
  19. S2CID 24179607
    .
  20. ^ "Nadolol: MedlinePlus Drug Information". www.nlm.nih.gov. Retrieved 27 May 2017.
  21. ^ "Nadolol Dosage Guide with Precautions - Drugs.com". drugs.com. Retrieved 27 May 2017.
  22. ^ "Corgard Label" (PDF). fda.gov. Retrieved 27 May 2017.
  23. ^
    PMID 33572109
    .
  24. PMID 18619928
    .

External links

  • "Nadolol". Drug Information Portal. U.S. National Library of Medicine.
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