Myopia
Myopia | |
---|---|
Other names | near-sightedness, short-sightedness |
Frequency | 1.5 billion people (22%)[2][4] |
Myopia, also known as near-sightedness and short-sightedness, is an eye disease[5][6][7] where light from distant objects focuses in front of, instead of on, the retina.[1][2][6] As a result, distant objects appear blurry while close objects appear normal.[1] Other symptoms may include headaches and eye strain.[1][8] Severe myopia is associated with an increased risk of macular degeneration, retinal detachment, cataracts, and glaucoma.[2][9]
Myopia results from the length of the eyeball growing too long or less commonly the
Tentative evidence indicates that the risk of myopia can be decreased by having young children spend more time outside.
Myopia is the most common eye problem and is estimated to affect 1.5 billion people (22% of the world population).
Etymology
The term myopia is of
Signs and symptoms
A myopic individual can see clearly out to a certain distance (the far point of the eye), but objects placed beyond this distance appear blurred.[15][30] If the extent of the myopia is great enough, even standard reading distances can be affected. Upon routine examination of the eyes, the vast majority of myopic eyes appear structurally identical to nonmyopic eyes.[31][30]
Onset is often in school children, with worsening between the ages of 8 and 15.[32][33]
Myopic individuals have
Causes
The underlying cause is believed to be a combination of genetic and environmental factors.
A 2012 review could not find strong evidence for any single cause, although many theories have been discredited.
A single-author literature review in 2021 proposed that myopia is the result of corrective lenses interfering with emmetropization.[44]
Genetics
A risk for myopia may be inherited from one's parents.[45] Genetic linkage studies have identified 18 possible loci on 15 different chromosomes that are associated with myopia, but none of these loci is part of the candidate genes that cause myopia. Instead of a simple one-gene locus controlling the onset of myopia, a complex interaction of many mutated proteins acting in concert may be the cause. Instead of myopia being caused by a defect in a structural protein, defects in the control of these structural proteins might be the actual cause of myopia.[46] A collaboration of all myopia studies worldwide identified 16 new loci for refractive error in individuals of European ancestry, of which 8 were shared with Asians. The new loci include candidate genes with functions in neurotransmission, ion transport, retinoic acid metabolism, extracellular matrix remodeling and eye development. The carriers of the high-risk genes have a tenfold increased risk of myopia.[47] Aberrant genetic recombination and gene splicing in the OPNLW1 and OPNMW1 genes that code for two retinal cone photopigment proteins can produce high myopia by interfering with refractive development of the eye.[48][49]
Human population studies suggest that contribution of genetic factors accounts for 60–90% of variance in refraction.[50][51][52][53] However, the currently identified variants account for only a small fraction of myopia cases, suggesting the existence of a large number of yet unidentified low-frequency or small-effect variants, which underlie the majority of myopia cases.[54]
Environmental factors
Environmental factors which increase the risk of myopia include insufficient light exposure, low physical activity, near work, and increased year of education.[32]
One hypothesis is that a lack of normal visual stimuli causes improper development of the eyeball. Under this hypothesis, "normal" refers to the environmental stimuli that the eyeball evolved to.[55] Modern humans who spend most of their time indoors, in dimly or fluorescently lit buildings may be at risk of development of myopia.[55]
People, and children especially, who spend more time doing
Myopia can be induced with minus spherical lenses,[62] and overminus in prescription lenses can induce myopia progression.[63][64] Overminus during refraction can be avoided through various techniques and tests, such as fogging, plus to blur, and the duochrome test.[64]
The near work hypothesis, also referred to as the "use-abuse theory" states that spending time involved in near work strains the intraocular and extraocular muscles. Some studies support the hypothesis, while other studies do not.[3] While an association is present, it is not clearly causal.[3]
Myopia is also more common in children with
Mechanism
Because myopia is a refractive error, the physical cause of myopia is comparable to any optical system that is out of focus. Borish and Duke-Elder classified myopia by these physical causes:[65][66]
- Axial myopia is attributed to an increase in the eye's axial length.[67]
- Refractive myopia is attributed to the condition of the refractive elements of the eye.[67] Borish further subclassified refractive myopia:[65]
- Curvature myopia is attributed to excessive, or increased, curvature of one or more of the refractive surfaces of the eye, especially the cornea.[67] In those with Cohen syndrome, myopia appears to result from high corneal and lenticular power.[68]
- Index myopia is attributed to variation in the index of refraction of one or more of the ocular media.[67]
As with any optical system experiencing a defocus aberration, the effect can be exaggerated or masked by changing the aperture size. In the case of the eye, a large pupil emphasizes refractive error and a small pupil masks it. This phenomenon can cause a condition in which an individual has a greater difficulty seeing in low-illumination areas, even though there are no symptoms in bright light, such as daylight.[69]
Under rare conditions, edema of the ciliary body can cause an anterior displacement of the lens, inducing a myopia shift in refractive error.[70]
Diagnosis
A diagnosis of myopia is typically made by an eye care professional, usually an optometrist or ophthalmologist.This is by refracting the eye with the use of cycloplegics such as Atropine with responses recorded when accommodation is relaxed.[11] Diagnosis of progressive myopia requires regular eye examination using the same method.[11]
Types
Various forms of myopia have been described by their clinical appearance:[66][71][72]
- Simple myopia: Myopia in an otherwise normal eye, typically less than 4.00 to 6.00 diopters.[73] This is the most common form of myopia.
- Degenerative myopia, also known as malignant, pathological, or progressive myopia, is characterized by marked fundus changes, such as posterior staphyloma, and associated with a high refractive error and subnormal visual acuity after correction.[67] This form of myopia gets progressively worse over time. Degenerative myopia has been reported as one of the main causes of visual impairment.[74]
- accommodation system.[75]
- Nocturnal myopia: Without adequate stimulus for accurate accommodation, the accommodation system partially engages, pushing distance objects out of focus.[73]
- Nearwork-induced transient myopia (NITM): short-term myopic far point shift immediately following a sustained near visual task.[76] Some authors argue for a link between NITM and the development of permanent myopia.[77]
- Instrument myopia: over-accommodation when looking into an instrument such as a microscope.[72]
- Induced myopia, also known as acquired myopia, results from various medications, increases in crystalline lens as a result of sorbitol accumulating in the lens. This edema often causes temporary myopia. Scleral buckles, used in the repair of retinal detachments may induce myopia by increasing the axial length of the eye.[78]
- Index myopia is attributed to variation in the index of refraction of one or more of the ocular media.[67] Cataracts may lead to index myopia.[79]
- Form deprivation myopia occurs when the eyesight is deprived by limited illumination and vision range,[80] or the eye is modified with artificial lenses[81] or deprived of clear form vision.[82] In lower vertebrates, this kind of myopia seems to be reversible within short periods of time. Myopia is often induced this way in various animal models to study the pathogenesis and mechanism of myopia development.[83]
Degree
The degree of myopia is described in terms of the power of the ideal correction, which is measured in diopters:[84]
- Myopia between −0.00 and −0.50 diopters is usually classified as emmetropia.
- Low myopia usually describes myopia between −0.50 and −3.00 diopters.[67]
- Moderate myopia usually describes myopia between −3.00 and −6.00 diopters.[67] Those with moderate amounts of myopia are more likely to have pigment dispersion syndrome or pigmentary glaucoma.[85]
- High myopia usually describes myopia of −6.00 or more.[67][86] People with high myopia are more likely to have retinal detachments[87] and primary open angle glaucoma.[88] They are also more likely to experience floaters, shadow-like shapes which appear in the field of vision.[89] In addition to this, high myopia is linked to macular degeneration, cataracts, and significant visual impairment.[90][91][92][93]
Age at onset
Myopia is sometimes classified by the age at onset:[84]
- Congenital myopia, also known as infantile myopia, is present at birth and persists through infancy.[73]
- Youth onset myopia occurs in early childhood or teenage, and the ocular power can keep varying until the age of 21, before which any form of corrective surgery is usually not recommended by ophthalmic specialists around the world.[73]
- School myopia appears during childhood, particularly the school age years.[94] This form of myopia is attributed to the use of the eyes for close work during the school years.[67] A 2004–2015 Singapore–Sydney study of children of Chinese descent found that time spent on outdoor activities was a factor.[95]
- Adult onset myopia
Prevention and control
Various methods have been employed in an attempt to decrease the progression of myopia, although studies show mixed results.
Spending time outdoors
Some studies have indicated that having children spend time outdoors reduces the incidence of myopia.[98] A 2017 study investigated the leading causal theory of association between greenspace exposure and spectacles use as a proxy for myopia, finding a 28% reduction in the likelihood of spectacles use per interquartile range increase in time spent in greenspace.[99] In Taiwan, government policies that require schools to send all children outdoors for a minimum amount of time have driven down the prevalence of myopia in children.[98][100]
Glasses and contacts
The use of reading glasses when doing close work may improve vision by reducing or eliminating the need to accommodate. Altering the use of eyeglasses between full-time, part-time, and not at all does not appear to alter myopia progression.[101][102] The American Optometric Association's Clinical Practice Guidelines found evidence of effectiveness of bifocal lenses and recommends it as the method for "myopia control".[73] In some studies, bifocal and progressive lenses have not shown differences in altering the progression of myopia compared to placebo.[96][103]
In 2019, contact lenses to prevent the worsening of nearsightedness in children were approved for use in the United States. This "MiSight" type claims to work by focusing peripheral light in front of the retina.[104]
Medication
Other methods
Scleral reinforcement surgery is aimed to cover the thinning posterior pole with a supportive material to withstand intraocular pressure and prevent further progression of the posterior staphyloma. The strain is reduced, although damage from the pathological process cannot be reversed. By stopping the progression of the disease, vision may be maintained or improved.[108] The use of orthoK can also slow down axial lens elongation.[109]
Treatment
The National Institutes of Health says there is no known way of preventing myopia, and the use of glasses or contact lenses does not affect its progression, unless the glasses or contact lenses are too strong of a prescription.[110] There is no universally accepted method of preventing myopia and proposed methods need additional study to determine their effectiveness.[73] Optical correction using glasses or contact lenses is the most common treatment; other approaches include orthokeratology, and refractive surgery.[73]: 21–26 Medications (mostly atropine) and vision therapy can be effective in addressing the various forms of pseudomyopia.
Glasses and contacts
Surgery
Refractive surgery includes procedures which alter the corneal curvature of some structure of the eye or which add additional refractive means inside the eye.
Photorefractive keratectomy
Photorefractive keratectomy (PRK) involves ablation of corneal tissue from the corneal surface using an excimer laser. The amount of tissue ablation corresponds to the amount of myopia. While PRK is a relatively safe procedure for up to 6 dioptres of myopia, the recovery phase post-surgery is usually painful.[111][112]
LASIK
In a
Phakic intra-ocular lens
Instead of modifying the corneal surface, as in laser vision correction (LVC), this procedure involves implanting an additional lens inside the eye (i.e., in addition to the already existing natural lens). While it usually results in good control of the refractive change, it can induce potential serious long-term complications such as glaucoma, cataract and endothelial decompensation.[115][116][117]
Orthokeratology
Orthokeratology or simply Ortho-K is a temporary corneal reshaping process using rigid gas permeable (RGP) contact lenses.[118] Overnight wearing of specially designed contact lenses will temporarily reshape cornea, so patients may see clearly without any lenses in daytime. Orthokeratology can correct myopia up to -6D.[119] Several studies shown that Ortho-K can reduce myopia progression also.[120][121] Risk factors of using Ortho-K lenses include microbial keratitis,[120] corneal edema,[122] etc. Other contact lens related complications like corneal aberration, photophobia, pain, irritation, redness etc. are usually temporary conditions, which may be eliminated by proper usage of lenses.[122]
Intrastromal corneal ring segment
The Intrastromal corneal ring segment (ICRS), commonly used in keratoconus treatment now, was originally designed to correct mild to moderate myopia.[123] The thickness is directly related to flattening and the diameter of the ring is proportionally inverse to the flattening of cornea. So, if diameter is smaller or thickness is greater, resulting myopia correction will be greater.[124]
Alternative medicine
A number of alternative therapies have been claimed to improve myopia, including vision therapy, "behavioural optometry", various eye exercises and relaxation techniques, and the Bates method.[125] Scientific reviews have concluded that there was "no clear scientific evidence" that eye exercises are effective in treating myopia[126] and as such they "cannot be advocated".[127]
Epidemiology
Global refractive errors have been estimated to affect 800 million to 2.3 billion.
The prevalence of myopia has been reported as high as 70–90% in some
Asia
In some parts of Asia, myopia is very common.
- Singapore is believed to have the highest prevalence of myopia in the world; up to 80% of people there have myopia, but the accurate figure is unknown.[135]
- In some areas, such as China and Malaysia, up to 41% of the adult population is myopic to 1.00 dpt,[137] and up to 80% to 0.5 dpt.[138]
- A study of Jordanian adults aged 17 to 40 found over half (54%) were myopic.[139]
- Some research suggests the prevalence of myopia in Indian children is less than 15%.[140]
Europe
- In first-year undergraduate students in the United Kingdom 50% of British whites and 53% of British Asians were myopic.[142]
- A recent review found 27% of Western Europeans aged 40 or over have at least −1.00 diopters of myopia and 5% have at least −5.00 diopters.[143]
North America
Myopia is common in the United States, with research suggesting this condition has increased dramatically in recent decades. In 1971–1972, the National Health and Nutrition Examination Survey provided the earliest nationally representative estimates for myopia prevalence in the U.S., and found the prevalence in persons aged 12–54 was 25%. Using the same method, in 1999–2004, myopia prevalence was estimated to have climbed to 42%.[144]
A study of 2,523 children in grades 1 to 8 (age, 5–17 years) found nearly one in 10 (9%) have at least −0.75 diopters of myopia.
A recent review found 25% of Americans aged 40 or over have at least −1.00 diopters of myopia and 5% have at least −5.00 diopters.[143]
Australia
In Australia, the overall prevalence of myopia (worse than −0.50 diopters) has been estimated to be 17%.[146] In one recent study, less than one in 10 (8%) Australian children between the ages of four and 12 were found to have myopia greater than −0.50 diopters.[147] A recent review found 16% of Australians aged 40 or over have at least −1.00 diopters of myopia and 3% have at least −5.00 diopters.[143]
South America
In Brazil, a 2005 study estimated 6% of Brazilians between the ages of 12 and 59 had −1.00 diopter of myopia or more, compared with 3% of the indigenous people in northwestern Brazil.[148] Another found nearly 1 in 8 (13%) of the students in the city of Natal were myopic.[149]
History
The difference between the near-sighted and far-sighted people was noted already by Aristotle.[150] Graeco-Roman physician Galen first used the term "myopia" (from Greek words "myein" meaning "to close or shut" and "ops" (gen. opos) meaning "eye") for near-sightedness.[150] The first spectacles for correcting myopia were invented by a German cardinal in the year 1451.[151] Johannes Kepler in his Clarification of Ophthalmic Dioptrics (1604) first demonstrated that myopia was due to the incident light focusing in front of the retina. Kepler also showed that myopia could be corrected by concave lenses.[150] In 1632, Vopiscus Fortunatus Plempius examined a myopic eye and confirmed that myopia was due to a lengthening of its axial diameter.[152]
The idea that myopia was caused by the eye strain involved in reading or doing other work close to the eyes was a consistent theme for several centuries.[100] In Taiwan, faced with a staggering rise in the number of young military recruits needing glasses, the schools were told to give students' eyes a 10-minute break after every half-hour of reading; however, the rate of myopia continued to climb.[100][153] The policy that reversed the epidemic of myopia was the government ordering all schools to have the children outside for a minimum of 80 minutes every day.[153]
Society and culture
The terms "myopia" and "myopic" (or the common terms "short-sightedness" or "short-sighted", respectively) have been used
Keeping children indoors, whether to promote early academic activities, because urban development choices leave no place for children to play outside, or because people avoid sunlight because of
Because myopia can be mitigated through lifestyle choices, it is possible that being myopic will become a marker of an impoverished or neglected childhood, with wealthy families ensuring that their children spend enough time outdoors to prevent or at least reduce it, and poor families, who rely on lower-quality childcare arrangements or not having access to a safe outdoor space, being unable to provide the same benefits to their children.[100]
Correlations
Numerous studies have found correlations between myopia, on the one hand, and intelligence and academic achievement, on the other;
See also
References
- ^ a b c d e f g h i j k l "Facts About Refractive Errors". NEI. October 2010. Archived from the original on 28 July 2016. Retrieved 30 July 2016.
- ^ PMID 24406412.
- ^ S2CID 32397628.
- ^ PMID 24357836.
- ^ "Myopia - EyeWiki".
- ^ a b "Nearsightedness: What Is Myopia?". American Academy of Ophthalmology. 22 September 2022. Retrieved 3 October 2023.
- ^ "Short-sightedness (myopia)". nhs.uk. 23 October 2017. Retrieved 3 October 2023.
- ^ Whitney S. "Eye Health and Nearsightedness in Children and Adults". WebMD. Retrieved 3 October 2023.
- PMID 32347918.
- ISBN 9781556427923. Archivedfrom the original on 8 September 2017.
- ^ ISBN 978-93-5152-063-4.
- PMID 26497977.
- PMID 28251836.
- S2CID 19400451.
- ^ a b "Short-sightedness (myopia)". nhs.uk. 23 October 2017. Retrieved 25 October 2023.
- ^ "Benefits of Vision Correction with Contact Lenses | Contact Lenses | CDC". www.cdc.gov. 30 November 2022. Retrieved 25 October 2023.
- PMID 27803858.
- ^ S2CID 42359341.
- S2CID 195756787.
- PMID 36060664.
- PMID 12016188.
- ^ "Common Eye Disorders and Diseases | CDC". www.cdc.gov. 29 September 2023. Retrieved 25 October 2023.
- ^ "Vision impairment and blindness". www.who.int. Retrieved 25 October 2023.
- Perseus Project.
- ISBN 9789004174184.
- ^ "μυωπία". Dictionary of Standard Modern Greek. Institute for Modern Greek Studies of the Artistotle University of Thessaloniki (in Greek). Retrieved 19 February 2016.
- ^ "myopia". Oxford English Dictionary (2nd ed.). Oxford University Press. 1989.
- ^ Harper D. "myopia". Online Etymology Dictionary.
- ^ WebMD E. "Hyperopia (Farsightedness)". WebMD. Retrieved 25 October 2023.
- ^ PMID 29266913, retrieved 25 October 2023
- PMID 31409949.
- ^ PMID 31781378.
- PMID 25958656.
- S2CID 27407880.
- PMID 25323850.
- PMID 35327754.
- PMID 29386878.
- PMID 26485393.
- ^ S2CID 198380872.
- S2CID 32003286.
- S2CID 201700595.
- S2CID 205349969.
- ^ PMID 25788077.
- PMID 34181975.
- ^ "Myopia (Nearsightedness)". www.aoa.org. Retrieved 25 December 2019.
- PMID 20036825.
- PMID 23396134.
- PMID 34440353.
- PMID 26114493.
- PMID 17065484.
- PMID 18757506.
- PMID 17724179.
- PMID 26313004.
- PMID 24385918.
- ^ a b c Lieberman, Daniel E. (2013) The Story of the Human Body: Evolution, Health, and Disease. New York: Pantheon Books.[page needed]
- ^ Sherwin J (25 October 2011). "Lack of outdoor play linked to short-sighted children". BBC News. Archived from the original on 25 October 2011. Retrieved 25 October 2011.
- S2CID 30301026.
- PMID 18294691.
- PMID 23380471.
- S2CID 35493712.
- PMID 23298452.
- PMID 28596085.
- ^ "Overminus Lenses Associated with Myopia Progression".
- ^ a b https://www.optometrystudents.com/pearl/over-minus-you-probably-do-itstop-it/ Archived 2 December 2022 at the Wayback Machine[unreliable medical source?][full citation needed]
- ^ a b Borish, Irvin M. (1949). Clinical Refraction. Chicago: The Professional Press.
- ^ ISBN 0-7000-1410-1.
- ^ ISBN 978-0-7506-9895-5.
- PMID 11980891.
- ^ The Eyecare Trust. Night Driving – The Facts. OR Eye care advice for driving in the dark Archived 20 March 2012 at the Wayback Machine 26 January 2005.'
- ^ PMID 18201514.
- OCLC 14967262.
- ^ S2CID 37513722.
- ^ a b c d e f g h i j American Optometric Association (1997). Optometric Clinical Practice Guideline: Care of the Patient with Myopia (PDF) (Report). Archived from the original (PDF) on 22 January 2015. Retrieved 17 February 2015.
- PMID 12022735.
- ISBN 0937404632.
- S2CID 2065074.
- S2CID 28700508.
- PMID 16193671.
- PMID 8310218.
- PMID 14009334.
- PMID 15980206.
- S2CID 31790023.
- PMID 15851585.
- ^ PMID 3307441.
- ^ "Glaucoma." Archived 19 August 2006 at the Wayback Machine EyeMDLink.com. Retrieved 27 August 2006.
- .
- ^ Retinal Detachment at eMedicine
- ^ "More Information on Glaucoma." AgingEye Times. Retrieved 27 August 2006.
- PMID 1589678.
- ^ Banerjee S, Horton J. Lenses and Spectacles to Prevent Myopia Worsening in Children [Internet]. Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2021 Apr. Available from:[1]
- ^ Walline JJ, Walker MK, Mutti DO, et al. Effect of High Add Power, Medium Add Power, or Single-Vision Contact Lenses on Myopia Progression in Children: The BLINK Randomized Clinical Trial. JAMA. 2020;324(6):571-580.
- ^ Ruiz-Pomeda A, Perez-Sanchez B, Valls I, Prieto-Garrido FL, Gutierrez-Ortega R, Villa-Collar C. MiSight Assessment Study Spain (MASS). A 2-year randomized clinical trial. Graefes Arch Clin Exp Ophthalmol. 2018;256(5):1011-1021.
- ^ Garcia-Del Valle AM, Blazquez V, Gros-Otero J, et al. Efficacy and safety of a soft contact lens to control myopia progression. Clin Exp Optom. 2021;104(1):14-21
- S2CID 18045281.
- ^ "School based program". Archived from the original on 10 November 2022. Retrieved 10 November 2022.
- ^ PMID 12386095.
- S2CID 258376819.
- ^ PMID 36809645.
- PMID 35614136.
- ^ ISSN 1059-1028. Retrieved 1 September 2023.
- PMID 10416930.
- PMID 2667638.
- PMID 30817825.
- ^ Office of the Commissioner (15 November 2019). "FDA approves first contact lens indicated to slow the progression of nearsightedness in children". FDA. Retrieved 18 November 2019.
- ^ PMID 31930781.
- PMID 26316834.
- PMID 31478936.
- PMID 19229272.
- PMID 30817825.
- ^ Near-sightedness Archived 10 May 2016 at the Wayback Machine. National Institutes of Health. 2010.
- PMID 6660257.
- PMID 3341427.
- S2CID 38655546.
- S2CID 2333450.
- PMID 15307392.
- S2CID 31750663.
- PMID 24748765.
- ^ "Orthokeratology (Ortho-k) - Corneal Reshaping with GP Contacts". www.contactlenses.org.
- ^ "Orthokeratology: A Heated Debate Continues". www.ophthalmologyweb.com.
- ^ a b "Orthokeratology slows myopic progression in young patients". American Academy of Ophthalmology. 17 April 2019.
- ^ "Orthokeratology (Ortho-K) treatment for Myopia Prevention and Control". www.myopiaprevention.org. Archived from the original on 6 February 2020. Retrieved 4 June 2020.
- ^ a b Daniels K. "Consider Ortho-K For Myopia Control". www.reviewofoptometry.com.
- PMID 26981548.
- ^ Pathak AK, Villarreal Gonzalez AJ, Karacal H. "ICRS: Corneal biomechanics effects".
- ISBN 1479118540.
- PMID 15825744.
- S2CID 13588501.
- ^ Dunaway D, Berger I. "Worldwide Distribution of Visual Refractive Errors and What to Expect at a Particular Location" Archived 29 January 2007 at the Wayback Machine. infocusonline.org.
- ^ a b Phakic Intraocular Lens (IOL) for Myopia Correction at eMedicine
- ^ PMID 12016188.
- ISBN 0-309-04081-7
- ISBN 0275961036
- PMID 6830491.
- S2CID 9323449.
- ^ "Discovery of Gene May Provide Treatment for Near-sightedness". Disabled-world.com. 12 September 2010. Retrieved 2 August 2012.[permanent dead link]
- ^ 全国近视眼人数近4亿 近视已影响国人健康 Archived 27 October 2012 at the Wayback Machine. Xinhua News Agency. Retrieved on 21 April 2013.
- PMID 5069190.
- S2CID 46445087.
- S2CID 24694696.
- PMID 29253002.
- PMID 25983215.
- S2CID 25384178.
- ^ PMID 15078666.
- PMID 20008719.
- ^ PMID 12912692.
- PMID 10326965.
- PMID 15705207.
- S2CID 38979284.
- PMID 16059562.
- ^ ISBN 978-1461483380.
- ^ "Myopia - Birth Story". Archived from the original on 20 April 2016. Retrieved 1 June 2020.
- PMID 4917270.
- ^ PMID 33909032.
- ^ Brooks, David (19 March 2009). Perverse Cosmic Myopia Archived 7 November 2015 at the Wayback Machine. New York Times.
- ^ Thompson C (17 September 2009). "Don't Work All the Time". Wired. Vol. 17, no. 8. Archived from the original on 17 August 2009. Retrieved 14 August 2009.
- PMID 28383074.
- PMID 25653868.
- PMID 25678690.
- PMID 29593642.